Results 1 to 10 of about 21,595 (116)

Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study [PDF]

Cardio-Oncology
Background Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Jian Chu, Lillian Tung, Issam Atallah, Changli Wei, Melody Cobleigh, Ruta Rao, Steven B. Feinstein, Lydia Usha, Kathrin Banach, Jochen Reiser, Tochukwu M. Okwuosa   +10 more
doaj   +2 more sources

Soluble Urokinase Plasminogen Activator Receptor Measurements: Influence of Sample Handling

The International Journal of Biological Markers, 2001
Aim The influence of sample handling on soluble urokinase plasminogen activator receptor (suPAR) concentrations in serum and EDTA plasma was studied in 16 healthy premenopausal women.
R. Riisbro, I.J. Christensen, C. Høgdall, N. Brünner, E. Høgdall   +4 more
doaj   +2 more sources

Urokinase-type plasminogen activator receptor as a predictive marker for cardiac disease among type 2 diabetic patients

Medical Journal of Babylon, 2023
Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj   +1 more source

Immune Activation Mediates the Association of Advanced Hepatic Fibrosis With Adverse Outcomes in Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Literature suggests a bidirectional association between advanced hepatic fibrosis (AHF) and coronary artery disease (CAD). We evaluated the association of AHF with immune activation, systemic inflammation, and adverse outcomes in patients with
Vardhmaan Jain, Anurag Mehta, Terence B. Lee, Chang Liu, Nicholas W. S. Chew, Yi‐An Ko, Matthew E. Gold, Daniel A. Gold, Nishant Vatsa, Shivang R. Desai, Jonathan H. Kim, Alireza Rahbar, Yazan Haroun, Kiran Ejaz, Salim S. Hayek, Mohammad S. Siddiqui, Fadi N. Salloum, Laurence S. Sperling, Arun J. Sanyal, Arshed A. Quyyumi   +19 more
doaj   +1 more source

The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis

Frontiers in Immunology, 2022
Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou, Ming-Li Zou, Ying-Ying Teng, Zhong-hua Chen, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Jun-Jie Wu, Zheng-Dong Yuan, Xiao-Yu Tang, Shun Yu, Jun-Xing Ye, Xia Li, Xiao-Jin Zhou, Feng-Lai Yuan, Feng-Lai Yuan   +15 more
doaj   +1 more source

Thrombo-inflammatory biomarkers to predict sepsis outcome

International Journal of Immunopathology and Pharmacology, 2021
Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses to infection and septic shock. Soluble urokinase plasminogen activator receptor (SuPAR) and plasminogen activator inhibitor-1(PAI-1)
Alaa Efat, Sabry Abdallah Shoeib, Ayman F Arafa, Ashraf Abdelraof Dawod, Mohamad A Abd ElHafez, Essam A Abd ElMohsen, Hany F Eladly, Reda A Ibrahim, Aly Elkholy   +8 more
doaj   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients

Romanian Journal of Laboratory Medicine, 2021
Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj   +1 more source

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
doaj   +1 more source

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Düzce Tıp Fakültesi Dergisi, 2021
Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt, Engin Şebin, Sibel İba Yılmaz, Ali Batur, Orhan Delice, Omer Karasahin, Kadir Küçükceran   +6 more
doaj   +1 more source