Results 1 to 10 of about 2,830 (159)

suPAR: An Inflammatory Mediator for Kidneys

Kidney Diseases, 2022
Background: Inflammation is a common feature of many kidney diseases. The implicated inflammatory mediators and their underlying molecular mechanisms however are often not clear.
Yashwanth Reddy Sudhini, Changli Wei, Jochen Reiser   +2 more
doaj   +3 more sources

Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

Biomarker Insights, 2011
The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases,
Lennart Ljunggren
exaly   +2 more sources

Serum profiling of uPA, PAI-1, and suPAR in systemic sclerosis: a preliminary study on analytical aspects and associations with microvascular and fibrotic manifestations [PDF]

Frontiers in Immunology
IntroductionIn systemic sclerosis (SSc), the laboratory panel lacks biomarkers able to predict the disease course and/or reflect the fibrotic activity in the skin and internal organs.
Filomena Napolitano, Ilaria Mormile, Ilaria Mormile, Gabriele Mignogna, Amato de Paulis, Amato de Paulis, Francesca Wanda Rossi, Francesca Wanda Rossi, Nunzia Montuori, Nunzia Montuori   +9 more
doaj   +2 more sources

Effect of simvastatin and ezetimibe on suPAR levels and outcomes [PDF]

Atherosclerosis, 2018
Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker associated with cardiovascular disease. Statins lower both low-density lipoprotein (LDL)-cholesterol and C-reactive protein (CRP), resulting in improved outcomes.
Casper N Bang, Julie Lyng Forman, Michael H Olsen   +2 more
exaly   +5 more sources

Sex Differences in Circulating Soluble Urokinase‐Type Plasminogen Activator Receptor (suPAR) Levels and Adverse Outcomes in Coronary Artery Disease

Journal of the American Heart Association, 2020
Background Women have higher circulating levels of soluble urokinase‐type plasminogen activator receptor (suPAR), and elevated suPAR is associated with cardiovascular risk.
Anurag Mehta, Yi-An Ko, Chang Liu
exaly   +3 more sources

Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury [PDF]

Molecular Medicine
Background Acute kidney injury (AKI) is a common complication among critically ill patients, associated with an increased risk of adverse outcomes.
Bingqing Wang, Jiabei Wang, Chen Qi, Chao Gao, Yue Wang, Yujie Zan, Yuwei Tan, Zhenying Wu, Jun Jiang, Jinmeng Suo, Jing Zhang, Zhiyong Peng   +11 more
doaj   +2 more sources

PTSD and suPAR: A multicohort investigation of chronic inflammation. [PDF]

Brain Behav Immun
Posttraumatic stress disorder (PTSD) is associated with poor health. Prior research has shown stressful events are associated with inflammatory biomarkers, such as soluble urokinase plasminogen activator receptor (suPAR), suggesting systemic chronic inflammation could be a mechanism linking adversity to poor health.
Bourassa KJ, Moffitt TE, Arseneault L, Barrett-Young A, Danese A, Garrett ME, Houts R, Matthews T, Poulton RG, Ramrakha S, Sprinckmoller S, Sugden K, Williams B, Beckham JC, Ashley-Koch AE, Kimbrel NA, Fisher HL, Theodore RF, Caspi A, Rasmussen LJH.   +19 more
europepmc   +4 more sources

Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study [PDF]

ESC Heart Failure
Aims Inflammation is postulated to be a key pathogenic mechanism in heart failure with preserved ejection fraction (HFpEF). Soluble urokinase plasminogen activator receptor (suPAR), a regulator of innate immune activity, is associated with incident heart
Christina G. Hutten, Annika Tekumulla, Anis Ismail, Alexi Vasbinder, Theresa Farhat, Pennelope Kunkle, Sascha N. Goonewardena, Ahmed Abdel‐Latif, Bertram Pitt, Salim S. Hayek   +9 more
doaj   +2 more sources

suPAR, a Circulating Kidney Disease Factor [PDF]

Frontiers in Medicine, 2021
Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with
Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser   +3 more
openaire   +3 more sources

Lessons learnt from thermo-mechanical feasibility assessment of pavement solar collectors using a FE-ANN approach

Case Studies in Construction Materials, 2023
This study presents a feasibility assessment of harvesting heat from asphalt pavement and a structural performance evaluation of a Pavement Solar Collector (PSC) in Utrecht, The Netherlands.
Taher Ghalandari, David Hernando, Navid Hasheminejad, Mahesh Moenielal, Cedric Vuye   +4 more
doaj   +1 more source