Results 91 to 100 of about 14,076 (220)

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma.

PLoS ONE, 2012
BackgroundMedulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in several cancers and well ...
Ramaprasada Rao Kotipatruni, Arun Kumar Nalla, Swapna Asuthkar, Christopher S Gondi, Dzung H Dinh, Jasti S Rao   +5 more
doaj   +1 more source

Urokinase-type plasminogen activator receptor combined with modified Alvarado scoring system and C-reactive protein for diagnosis of acute appendicitis in children

Di-san junyi daxue xuebao, 2020
Objective To investigate the serum level of urokinase-type plasminogen activator receptor (uPAR) in children with acute appendicitis and assess the diagnostic value of uPAR combined with C-reactive protein (CRP) and modified Alvarado score for acute ...
SUN Chuanwei, LI Aijun, SUN Hong, ZHANG Wei, WANG Guibo, LEI Jie, YANG Zhonggang   +6 more
doaj   +1 more source

A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions

Aging Cell, Volume 25, Issue 9, September 2026.
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang   +4 more
wiley   +1 more source

Copenhagen uPAR prostate cancer (CuPCa) database:protocol and early results

, 2016
AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels
Iversen, Peter, Brasso, Klaus, Berg, Kasper D, Christensen, Ib J, Røder, Martin A, Lippert, Solvej, Lund, Ida K, Høyer-Hansen, Gunilla   +7 more
core   +1 more source

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells

Blood Advances, 2017
: The plasminogen activation (PA) system has been implicated in driving inflammatory arthritis, but the precise contribution of PA system components to arthritis pathogenesis remains poorly defined. Here, the role of urokinase plasminogen activator (uPA)
Sherry Thornton, Harini Raghu, Carolina Cruz, Malinda D. Frederick, Joseph S. Palumbo, Eric S. Mullins, Kasper Almholt, Pernille A. Usher, Matthew J. Flick   +8 more
doaj   +1 more source

Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis

Microorganisms, 2020
(1) Background: Persistent Helicobacter pylori infection is the most important risk factor for gastric cancer. The urokinase receptor (uPAR) is upregulated in lesions harboring cancer invasion and inflammation.
Warner Alpízar-Alpízar, Mette E. Skindersoe, Lone Rasmussen, Mette C. Kriegbaum, Ib J. Christensen, Ida K. Lund, Martin Illemann, Ole D. Laerum, Karen A. Krogfelt, Leif P. Andersen, Michael Ploug   +10 more
doaj   +1 more source

Low‐Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle‐Aged and Older Adults: Study Protocol for a Triple‐Blind, Randomised, Placebo‐Controlled Trial

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and senolytic effects in vitro and in animal models, but evidence from randomised
Juliette Tavenier, Magnus Berglind, Line Fleischer Hach, Louise Westberg Strejby Christensen, Maria Jana Masarikova, Rafal Yahya, Mette Bendtz Lindstrøm, Baker Nawfal Jawad, Anna Zatkova, Rikke Lundsgaard Nielsen, Helle Gybel Juul‐Larsen, Thomas Kallemose, Jan Olof Nehlin, Morten Baltzer Houlind, Ove Andersen, Line Jee Hartmann Rasmussen   +15 more
wiley   +1 more source

uPAR carrying S90E and S90P substitutions. A

, 2012
: Arg91 and Tyr92 superposition of the backbone atoms of the various 88–92 segments of SuPAR from x-ray structures. Residue 89 is not visible in the electron density map of 1YWH. Side chains are reported as stick, Arg residues are in blue.
Katia Bifulco (133627), Vincenzo Pavone (133641), Giuseppe Pirozzi (133651), Paola Franco (133638), Claudio Arra (133331), Maria Teresa Masucci (133648), Maria Vincenza Carriero (133657), Immacolata Longanesi-Cattani (133632), Pietro Mugione (133644), Maria Patrizia Stoppelli (133653), Gioconda Di Carluccio (133646)   +10 more
core   +1 more source

uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

PLoS ONE, 2015
The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder.
Line Hammer Dohn, Helle Pappot, Benedikte Richter Iversen, Martin Illemann, Gunilla Høyer-Hansen, Ib Jarle Christensen, Peter Thind, Lisbeth Salling, Hans von der Maase, Ole Didrik Laerum   +9 more
doaj   +1 more source

Prospective phase II trial of [68Ga]Ga-NOTA-AE105 uPAR-PET/MRI in patients with primary gliomas: Prognostic value and Implications for uPAR-targeted Radionuclide Therapy

EJNMMI Research
Background Treatment of patients with low-grade and high-grade gliomas is highly variable due to the large difference in survival expectancy. New non-invasive tools are needed for risk stratification prior to treatment.
Aleena Azam, Sorel Kurbegovic, Esben Andreas Carlsen, Thomas Lund Andersen, Vibeke André Larsen, Ian Law, Jane Skjøth-Rasmussen, Andreas Kjaer   +7 more
doaj   +1 more source