Results 51 to 60 of about 14,076 (220)
The FASEB Journal, 2018 Human CYP1B1 is known as a major metabolizer for estrogen and shows tumor‐specific hyper‐expression. To explore the role of CYP1B1 on metastasis of human cancer cells, we studied the effects of CYP1B1 inhibition and activation in MCF‐10A, MCF‐7, MDA‐MB‐231, and HeLa cells.
Yeo‐Jung Kwon +3 more
openaire +1 more source
uPAR expression controls cell migration.
, 2014 uPAR-293 and V-293 cells efficiently migrate toward serum growth factors or EGF (GF). However, uPAR, when expressed, recruits and bridges fMLFRs and β1 integrin at the cell surface, thus driving pro-migratory signaling (upper panels).
Nunzia Montuori (511913) +6 more
core +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Emerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic melanoma.
Michele Guida +10 more
doaj +1 more source
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis [PDF]
Journal of Investigative Dermatology, 2008 The fibrinolytic system is considered to play an important role in the degradation of extracellular matrices (ECM). However, the detailed mechanism regarding how this system affects fibrosis remains unclear. Urokinase-type plasminogen activator receptor (uPAR) not only functions as a proteinase receptor but also plays a role in cellular adhesion ...
Kanno, Yosuke +9 more
openaire +2 more sources
Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]
, 2014 Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Portelli, Michael A. +2 more
core
Frontiers in Pharmacology, 2020 Urokinase-type plasminogen activator receptor (uPAR) plays a crucial role in inflammation and tumor metastasis. Docosahexaenoic acid (DHA), a representative omega-3 polyunsaturated fatty acid, has been shown to exhibit anti-inflammatory and anti-tumor ...
Sen Lian +6 more
doaj +1 more source
Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair
Advanced Science, EarlyView.This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang +8 more
wiley +1 more source
Urokinase Anchors uPAR to the Actin Cytoskeleton
Investigative Opthalmology & Visual Science, 2004 To investigate the expression and localization of urokinase plasminogen activator (uPA) and its receptor (uPAR) and their interaction with the actin cytoskeleton in human corneal fibroblasts.Primary cultured human corneal fibroblasts were exposed to exogenous uPA to investigate its effect on the distribution of uPAR under resting conditions and in a ...
Audrey M, Bernstein +3 more
openaire +3 more sources
uPAR is found in endocytic compartments in the absence of ligands in HEK293-uPAR cells.
, 2013 Immunofluorescence of HEK293-uPAR cells labeled with a polyclonal anti-uPAR antibody and imaged by confocal microscopy. Image 2 (left), shows the predominant location of uPAR in lamellipodia-like protrusions and in intracellular compartments, including ...
Francesco Blasi (61418) +4 more
core +1 more source