Results 51 to 60 of about 14,579 (261)
The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils. [PDF]
PLoS ONE, 2011 The urokinase-type plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol (GPI) anchored membrane protein, regulates urokinase (uPA) protease activity, chemotaxis, cell-cell interactions, and phagocytosis of apoptotic cells.
Gang Liu +7 more
doaj +1 more source
Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]
, 2003 Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R. +9 more
core +1 more source
Identification of uPAR-positive chemoresistant cells in small cell lung cancer. [PDF]
PLoS ONE, 2007 BACKGROUND: The urokinase plasminogen activator (uPA) and its receptor (uPAR/CD87) are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions.
Margarita Gutova +6 more
doaj +1 more source
Клиническая онкогематология, 2022 Aim. To generate anti-CD87 CAR-T lymphocytes and to assess their in vitro functional activity. Materials & Methods. Т-lymphocytes isolated from healthy donor peripheral blood were transduced with the anti-CD87-CAR, T2A, and FusionRed gene coding ...
M. V. Neklesova +5 more
doaj +1 more source
Human antibody VH domains targeting uPAR as candidate therapeutics for cancers
Frontiers in Oncology, 2023 The high expression of uPAR has been linked to tumor progression, invasion, and metastasis in several types of cancer. Such overexpression of uPAR makes it a potential target for immunotherapies across common cancers such as breast, colorectal, lung ...
Xiaojie Chu +7 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Urokinase-type plasminogen activator receptor (uPAR) plays a crucial role in inflammation and tumor metastasis. Docosahexaenoic acid (DHA), a representative omega-3 polyunsaturated fatty acid, has been shown to exhibit anti-inflammatory and anti-tumor ...
Sen Lian +6 more
doaj +1 more source
Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling
Cancer Biology & Therapy, 2023 Vascular endothelial growth factor (VEGF) plays key roles in angiogenesis, vasculogenesis, and wound healing. In cancers, including triple negative breast cancer (TNBC), VEGF has been associated with increased invasion and metastasis, processes that ...
Eibhlin Goggins +6 more
doaj +1 more source
The FASEB Journal, 2018 Human CYP1B1 is known as a major metabolizer for estrogen and shows tumor‐specific hyper‐expression. To explore the role of CYP1B1 on metastasis of human cancer cells, we studied the effects of CYP1B1 inhibition and activation in MCF‐10A, MCF‐7, MDA‐MB‐231, and HeLa cells.
Yeo‐Jung Kwon +3 more
openaire +1 more source
The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis [PDF]
Journal of Investigative Dermatology, 2008 The fibrinolytic system is considered to play an important role in the degradation of extracellular matrices (ECM). However, the detailed mechanism regarding how this system affects fibrosis remains unclear. Urokinase-type plasminogen activator receptor (uPAR) not only functions as a proteinase receptor but also plays a role in cellular adhesion ...
Kanno, Yosuke +9 more
openaire +2 more sources
Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis
Cancer Cell International, 2006 Background The urokinase receptor (uPAR) governs several functions necessary during invasion and metastasis such as motility, degradation of the extracellular matrix and adhesion.
Francis Joseph +2 more
doaj +1 more source