Results 51 to 60 of about 14,530 (214)
Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam +4 more
wiley +2 more sources
Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis
Cancer Cell International, 2006 Background The urokinase receptor (uPAR) governs several functions necessary during invasion and metastasis such as motility, degradation of the extracellular matrix and adhesion.
Francis Joseph +2 more
doaj +1 more source
Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation
iNew Medicine, EarlyView.The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li +11 more
wiley +1 more source
The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis [PDF]
Journal of Investigative Dermatology, 2008 The fibrinolytic system is considered to play an important role in the degradation of extracellular matrices (ECM). However, the detailed mechanism regarding how this system affects fibrosis remains unclear. Urokinase-type plasminogen activator receptor (uPAR) not only functions as a proteinase receptor but also plays a role in cellular adhesion ...
Kanno, Yosuke +9 more
openaire +2 more sources
Urokinase plasminogen activator receptor (uPAR) as a novel biomarker in prostate cancer.
, 2015 183 Background: New biomarkers are warranted to distinguish between indolent and aggressive prostate cancer (PCa). The urokinase plasminogen activator receptor (uPAR) plays an important role in pericellular proteolysis by binding urokinase plasminogen ...
M. Andreas Røder +6 more
core +1 more source
Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View
Frontiers in Cell and Developmental Biology, 2022 Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum ...
Daniela Alfano +2 more
doaj +1 more source
Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis
Interdisciplinary Medicine, EarlyView.Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar +18 more
wiley +1 more source
uPAR co-immunoprecipitates with fMLF-Rs.
, 2014 A: Lysates of uPAR-293 cells or V-293 cells, transiently transfected with FPR1 cDNA, were analyzed by Western blot with a uPAR-specific monoclonal antibody or immunoprecipitated with anti-FPR1 polyclonal antibodies or nonimmune rabbit immunoglobulins and
Nunzia Montuori (511913) +6 more
core +1 more source
TGF-β regulation of the uPA/uPAR axis modulates mesothelial-mesenchymal transition (MesoMT)
Scientific Reports, 2021 Pleural fibrosis (PF) is a chronic and progressive lung disease which affects approximately 30,000 people per year in the United States. Injury and sustained inflammation of the pleural space can result in PF, restricting lung expansion and impairing ...
Ranisha Logan +8 more
doaj +1 more source
Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation
Integrative Zoology, EarlyView.Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv +4 more
wiley +1 more source