Results 21 to 30 of about 14,579 (261)
Functional characterization of αMβ2-uPar interaction [PDF]
, 2009 The cell adhesion molecule integrin αMβ2, one of the β2 integrins, associates with the urokinase-type plasminogen activator receptor (uPAR) on monocytes and neutrophils.
Tang, Manli
core +4 more sources
uPAR mediated anticancer activity of PEDF [PDF]
Cancer Biology & Therapy, 2008 Osteosarcoma (OS) is a cancer which afflicts the bone, ending in usually fatal lung metastasis mainly in teenagers and adolescents. We have recently shown that PEDF is one biological that has multiple anti-OS activity. In parallel, we have also shown
Dass, Crispin R, Choong, Peter F. M
core +4 more sources
FEBS Letters, 2000 Applying a novel, highly specific and sensitive immunoabsorption/Western blotting technique we have identified in vitro in conditioned cell culture medium and in vivo in human urine different soluble forms of the urokinase-type plasminogen activator ...
Nicolai Sidenius +5 more
core +3 more sources
Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer [PDF]
BMC Cancer, 2017 Background Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor ...
Anders Christensen +11 more
doaj +2 more sources
Copenhagen Upar Prostate Cancer (CuPCa) Database: Protocol and Early Results
Biomarkers in Medicine, 2016 AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels
Kasper Drimer Berg +2 more
exaly +2 more sources
uPAR as a Glioma Imaging Target [PDF]
Journal of Nuclear Medicine, 2015 Gliomas account for 70% of primary brain tumors ([1][1]). Among the various types of glioma, glioblastoma is the most aggressive astrocytic tumor, being classified grade IV by the World Health Organization ([2][2]). Although CT and MRI are indispensable in providing morphologic information,
Kenji Hirata, Nagara Tamaki
openalex +3 more sources
Characterization and function of human Ly-6/uPAR molecules [PDF]
BMB Reports, 2012 Human Ly-6/uPAR molecules are a superfamily composed oftwo subfamilies; one is the membrane bound proteins with aGPI-anchor and the other are secreted proteins without theGPI-anchor.
Hyun Kyung Kong & Jong Hoon Park*
doaj +1 more source
Crystal structure and cellular functions of uPAR dimer [PDF]
Nature Communications, 2022 Abstract Receptor dimerization of urokinase-type plasminogen activator receptor (uPAR) was previously identified at protein level and on cell surface. Recently, a dimeric form of mouse uPAR isoform 2 was proposed to induce kidney disease. Here, we report the crystal structure of human uPAR dimer at 2.96 Å.
Shujuan Yu +9 more
openalex +4 more sources
Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor-binding mechanisms. [PDF]
Acta Crystallogr D Struct BiolThis study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Murakami S +9 more
europepmc +2 more sources
Research Progress of Targeting uPA-uPAR System in Tumor Therapy
Zhongliu Fangzhi Yanjiu, 2023 The uPA-uPAR system is highly expressed in various tumor tissues. This system can promote the degradation of extracellular matrix proteins, as well as combine with vitronectin and integrin to transmit intracellular signal transduction.
CAI Weiwen +5 more
doaj +1 more source