Results 11 to 20 of about 14,076 (220)
Domain 1 of the urokinase receptor (uPAR) is required for uPAR‐mediated cell binding to vitronectin [PDF]
FEBS Letters, 2000 In the present paper we have analyzed uPAR‐mediated cellular binding to vitronectin using the murine erythroid progenitor cell line 32D. We show that expression of uPAR in 32D cells promotes cellular binding to vitronectin, but fails to support cell spreading.
Sidenius, Nicolai, Blasi, Francesco
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uPAR mediates anticancer activity of PEDF [PDF]
Cancer Biology & Therapy, 2008 Osteosarcoma (OS) is a cancer which afflicts the bone, ending in usually fatal lung metastasis mainly in teenagers and adolescents. We have recently shown that PEDF is one biological that has multiple anti-OS activity. In parallel, we have also shown using rodent cells, the beneficial effects of downregulation of uPAR against OS.
Dass, Crispin R, Choong, Peter F. M
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A doxycycline-inducible urokinase receptor (uPAR) upregulates uPAR activities including resistance to anoikis in human prostate cancer cell lines [PDF]
Molecular Cancer, 2007 Background The urokinase receptor (uPAR) mediates a diverse array of cellular processes including several events involved in prostate cancer metastasis.
Reiser Jakob +4 more
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The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. [PDF]
PLoS Pathogens, 2009 The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated.
Joppe W R Hovius +15 more
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Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo [PDF]
FEBS Letters, 2000 Applying a novel, highly specific and sensitive immunoabsorption/Western blotting technique we have identified in vitro in conditioned cell culture medium and in vivo in human urine different soluble forms of the urokinase‐type plasminogen activator receptor (uPAR/CD87). These include the uPAR fragment D2D3 and the never before identified domain 1 (D1)
Sidenius, Nicolai +2 more
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Functional characterization of αMβ2-uPar interaction [PDF]
, 2019 DOCTOR OF PHILOSOPHY (SBS)
Tang, Manli
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Characterization and function of human Ly-6/uPAR molecules [PDF]
BMB Reports, 2012 Human Ly-6/uPAR molecules are a superfamily composed oftwo subfamilies; one is the membrane bound proteins with aGPI-anchor and the other are secreted proteins without theGPI-anchor.
Hyun Kyung Kong & Jong Hoon Park*
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Clinical and Translational Allergy, 2023 Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown.
Michael A. Portelli +8 more
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Pharmaceuticals, 2023 During tumorigenesis, urokinase (uPA) and uPA receptor (uPAR) play essential roles in mediating pathological progression in many cancers. To understand the crosstalk between the uPA/uPAR signaling and cancer, as well as to decipher their cellular ...
Yu-Ching Chang +4 more
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Frontiers in Cell and Developmental Biology, 2021 The interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell surfaces, thereby regulating extravascular fibrinolysis, cell adhesion, and ...
Julie Maja Leth +3 more
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