Results 11 to 20 of about 14,579 (261)
New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms [PDF]
Cells, 2020 The urokinase (uPA) receptor (uPAR) plays a key role in cell migration. We previously showed that uPAR-negative HEK-293 cells efficiently migrate toward serum but, after uPAR ectopic expression, migrate only in a uPAR-dependent manner. In fact, migration
Mariaevelina Alfieri +2 more
exaly +5 more sources
Differential Roles of uPAR in Peritoneal Ovarian Carcinomatosis
Neoplasia: An International Journal for Oncology Research, 2012 Epithelial ovarian cancer is the fourth leading cause of death from gynecologic malignancies in the United States. Most cases are diagnosed at late stages, with the solid tumor masses growing as peritoneal implants, or floating within the ascitic fluid ...
Nada N. Al-Hassan +6 more
doaj +4 more sources
RhoB regulates uPAR signalling [PDF]
Journal of Cell Science, 2012 uPA and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion. Rho GTPases are key coordinators of these processes; the Rho GTPase Rac1 has previously been implicated in uPA/uPAR-induced migratory or ...
RAGNO, Pia +6 more
core +8 more sources
Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells
Cancers, 2022 The 3′ untranslated region (3′UTR) of the urokinase (uPA) receptor (uPAR) mRNA can act as a competitive endogenous RNA (ceRNA) in acute myeloid leukaemia (AML) cells, promoting the expression of pro-tumoral targets, including uPAR.
Mariaevelina Alfieri +2 more
exaly +3 more sources
Frontiers in Cell and Developmental Biology, 2021 The interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell surfaces, thereby regulating extravascular fibrinolysis, cell adhesion, and ...
Michael Ploug, Ploug Michael
exaly +3 more sources
Molecular Cancer, 2007 Background The urokinase receptor (uPAR) mediates a diverse array of cellular processes including several events involved in prostate cancer metastasis.
Reiser Jakob +4 more
doaj +2 more sources
Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin [PDF]
FEBS Letters, 2000 In the present paper we have analyzed uPAR-mediated cellular binding to vitronectin using the murine erythroid progenitor cell line 32D. We show that expression of uPAR in 32D cells promotes cellular binding to vitronectin, but fails to support cell ...
Nicolai Sidenius +3 more
core +3 more sources
The Association between Plasma Levels of Intact and Cleaved uPAR Levels and the Risk of Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer [PDF]
Diagnostics, 2020 Radical prostatectomy (RP) is a curatively intended treatment option for clinically localized non-metastatic prostate cancer (PCa). Novel biomarkers could refine treatment choice based on a better identification of men at risk of biochemical recurrence ...
Hein Vincent Stroomberg +5 more
doaj +2 more sources
Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease [PDF]
International Journal of Nephrology, 2017 Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure.
Hernán Trimarchi +16 more
doaj +2 more sources
The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. [PDF]
PLoS Pathogens, 2009 The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated.
Joppe W R Hovius +15 more
doaj +3 more sources