Results 11 to 20 of about 14,530 (214)
Differential Roles of uPAR in Peritoneal Ovarian Carcinomatosis
Neoplasia: An International Journal for Oncology Research, 2012 Epithelial ovarian cancer is the fourth leading cause of death from gynecologic malignancies in the United States. Most cases are diagnosed at late stages, with the solid tumor masses growing as peritoneal implants, or floating within the ascitic fluid ...
Nada N. Al-Hassan +6 more
doaj +4 more sources
RhoB regulates uPAR signalling [PDF]
Journal of Cell Science, 2012 uPA and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion. Rho GTPases are key coordinators of these processes; the Rho GTPase Rac1 has previously been implicated in uPA/uPAR-induced migratory or morphological cell responses.
Daniela Alfano +3 more
core +8 more sources
uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor [PDF]
Aging Cell, Volume 25, Issue 10, October 2026.GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng +13 more
wiley +2 more sources
Functional characterization of αMβ2-uPar interaction [PDF]
, 2019 DOCTOR OF PHILOSOPHY (SBS)
Tang, Manli
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uPAR-directed immunotherapies in solid tumors: current advances and future perspectives [PDF]
Frontiers in PharmacologyIn cancer, elevated expression of the urokinase-type plasminogen activator receptor (uPAR) is a well-established adverse prognostic factor associated with enhanced tumor invasion, metastatic dissemination, cellular proliferation, and resistance to ...
Filomena Napolitano +2 more
doaj +2 more sources
Characterization and function of human Ly-6/uPAR molecules [PDF]
BMB Reports, 2012 Human Ly-6/uPAR molecules are a superfamily composed oftwo subfamilies; one is the membrane bound proteins with aGPI-anchor and the other are secreted proteins without theGPI-anchor.
Hyun Kyung Kong & Jong Hoon Park*
doaj +1 more source
uPAR deficiency triggers TGFβ1-mediated fibrotic remodeling in a cardiac perivascular-like microenvironment [PDF]
Stem Cell Research & TherapyBackground Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling.
Yulia Goltseva +10 more
doaj +2 more sources
Cell Adhesion & Migration, 2013 Vascular endothelial growth factor (VEGF)-initiated angiogenesis requires both coordinated proteolytic degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell-migration provided by integrin-matrix interaction.
Pavel, Uhrin, Johannes M, Breuss
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uPAR: An Essential Factor for Tumor Development [PDF]
Journal of Cancer, 2021 Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is controlled by many factors in tumorigenesis and is expressed in many tumor tissues.
Lv, Tao +8 more
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uPAR as a Glioma Imaging Target [PDF]
Journal of Nuclear Medicine, 2015 Gliomas account for 70% of primary brain tumors ([1][1]). Among the various types of glioma, glioblastoma is the most aggressive astrocytic tumor, being classified grade IV by the World Health Organization ([2][2]). Although CT and MRI are indispensable in providing morphologic information,
Kenji, Hirata, Nagara, Tamaki
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