Results 41 to 50 of about 14,304 (250)

Caveolar dysfunction leads to signal transduction defects that are critical for obesity-driven disorders [PDF]

, 2006
To say that obesity and diabetes have reached epidemic proportions has become something of a cliché. This should not lead us to simply accept it as a byproduct of our changing lifestyle, or to overlook the socioeconomic importance of these conditions ...
Venugopal, Joshi
core   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. [PDF]

PLoS ONE, 2012
The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration. uPAR binds urokinase and vitronectin extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide ...
Katia Bifulco, Immacolata Longanesi-Cattani, Paola Franco, Vincenzo Pavone, Pietro Mugione, Gioconda Di Carluccio, Maria Teresa Masucci, Claudio Arra, Giuseppe Pirozzi, Maria Patrizia Stoppelli, Maria Vincenza Carriero   +10 more
doaj   +1 more source

Immunologic Detection of the Cellular Receptor for Urokinase Plasminogen Activator [PDF]

Clinical Immunology and Immunopathology, 1994
The cellular receptor for urokinase plasminogen activator (uPA-R) is a monomeric phosphatidylinositol-linked glycoprotein (gp40-65) that may contribute to the invasive capacity of tumor and inflammatory cells by focusing the activity of urokinase (uPA) in converting plasminogen to plasmin, a serine protease capable of degrading extracellular matrix ...
Mizukami, Ikuko F., Garni-Wagner, Beth Ann, DeAngelo, L. Michael, Liebert, Monica, Flint, Andrew, Lawrence, David A., Cohen, Robert L., Todd, Robert F. III   +7 more
openaire   +3 more sources

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines

Journal of Neuroinflammation, 2019
Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias, Elisabetta Mantuano   +8 more
doaj   +1 more source

PAI-1: An Integrator of Cell Signaling and Migration

International Journal of Cell Biology, 2011
Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), and the
Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins   +8 more
doaj   +1 more source

Changes in serum angiogenic factors among patients with acute pain and subacute pain

Frontiers in Molecular Neuroscience, 2022
Screening serum biomarkers for acute and subacute pain is important for precise pain management. This study aimed to examine serum levels of angiogenic factors in patients with acute and subacute pain as potential biomarkers. Serum samples were collected
Xuewei Yang, Chunmei Yuan, Huanling Wang, Yunxia Wang, Mei Liu, Zongjin Li, Jun Zhang, Jun Zhang   +7 more
doaj   +1 more source

Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. [PDF]

, 2012
Mesothelial cells are critical in the pathogenesis of post-surgical intraabdominal adhesions as well as in the deterioration of the peritoneal membrane associated with long-term peritoneal dialysis.
Elfriede Noessner, Susan Notohamiprodjo, Pankaj Goyal, Sauter, M., Sitter, T., Sitter, Thomas, Markus Wörnle, Andrea Ribeiro, Peter J. Nelson (168215), Thomas Sitter, Matthias Sauter (168187), Wolfgang Siess, Wolfgang Siess (168198), Susanne Himmelein, Nelson, P.J., Himmelein, Susanne, Thomas Sitter (168211), Goyal, P., Sauter, Matthias, Susanne Himmelein (168206), Nelson, Peter J., Markus Wörnle (168201), Susan Notohamiprodjo (168192), Ribeiro, A., Notohamiprodjo, Susan, Elfriede Noessner (146689), Noessner, Elfriede, Wörnle, Markus, Djafarzadeh, Roghieh, Roghieh Djafarzadeh, Matthias Sauter, Nößner, E., Andrea Ribeiro (168203), Roghieh Djafarzadeh (88033), Himmelein, S., Peter J Nelson, Wörnle, M., Goyal, Pankaj, Ribeiro, Andrea, Djafarzadeh, R., Notohamiprodjo, S., Pankaj Goyal (156516), Siess, W., Siess, Wolfgang   +43 more
core   +1 more source

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor [PDF]

Journal of Biological Chemistry, 1995
Single-chain urokinase (scuPA), the unique form of urokinase secreted by cells, is converted to an active two-chain molecule through the cleavage of a single peptide bond by plasmin and other specific proteinases. Although scuPA may express limited enzymatic activity, its contribution to plasminogen activation on cell surfaces remains uncertain ...
A, Higazi, R L, Cohen, J, Henkin, D, Kniss, B S, Schwartz, D B, Cines   +5 more
openaire   +2 more sources

Guidelines for the use of tumor markers in breast cancer [PDF]

Journal of Medical Biochemistry, 2007
The best-validated markers in breast cancer are all tissue based and include estrogen receptors (ER), progesteron receptors (PR), HER-2, urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1). Assay of ER, PR and HER-2 is now
Ignjatović Svetlana
doaj