Results 31 to 40 of about 676,629 (244)
The structure of the urokinase-type plasminogen activator receptor gene [PDF]
Blood, 1994 The cellular receptor for urokinase-type plasminogen activator (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a central role in pericellular plasminogen activation. It contains 313 amino acid residues, including 28 cysteine residues in a pattern of three homologous repeats. The cysteine residue pattern suggests that
J R, Casey +4 more
openaire +3 more sources
Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer [PDF]
EJNMMI Research, 2020 AbstractThe urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved such as inflammation, but also in diseases as arthritis and cancer. Normally, uPAR is absent in healthy tissues.
Baart, V.M. +6 more
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PAI-1: An Integrator of Cell Signaling and Migration
International Journal of Cell Biology, 2011 Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), and the
Ralf-Peter Czekay +8 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Tumor markers in breast cancer - European Group on Tumor Markers recommendations [PDF]
, 2005 Recommendations are presented for the routine clinical use of serum and tissue-based markers in the diagnosis and management of patients with breast cancer.
Einarsson, Roland +10 more
core +1 more source
Urokinase-Type Plasminogen Activator Receptor: A Beacon of Malignancy? [PDF]
Clinical Cancer Research, 2008 Abstract Discriminating between benign and malignant disease is a pivotal diagnostic issue in the care of women with pelvic masses. Identification of serum biomakers that can rellably make the distinction would aid in the proper referral for patient care and may provide leads in the development of early detection strategies.
Ronny, Drapkin +2 more
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Changes in serum angiogenic factors among patients with acute pain and subacute pain
Frontiers in Molecular Neuroscience, 2022 Screening serum biomarkers for acute and subacute pain is important for precise pain management. This study aimed to examine serum levels of angiogenic factors in patients with acute and subacute pain as potential biomarkers. Serum samples were collected
Xuewei Yang +7 more
doaj +1 more source
Guidelines for the use of tumor markers in breast cancer [PDF]
Journal of Medical Biochemistry, 2007 The best-validated markers in breast cancer are all tissue based and include estrogen receptors (ER), progesteron receptors (PR), HER-2, urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1). Assay of ER, PR and HER-2 is now
Ignjatović Svetlana
doaj
Immunologic Detection of the Cellular Receptor for Urokinase Plasminogen Activator [PDF]
Clinical Immunology and Immunopathology, 1994 The cellular receptor for urokinase plasminogen activator (uPA-R) is a monomeric phosphatidylinositol-linked glycoprotein (gp40-65) that may contribute to the invasive capacity of tumor and inflammatory cells by focusing the activity of urokinase (uPA) in converting plasminogen to plasmin, a serine protease capable of degrading extracellular matrix ...
Mizukami, Ikuko F. +7 more
openaire +3 more sources
Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry
Angewandte Chemie, EarlyView.Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam +4 more
wiley +2 more sources