Results 31 to 40 of about 23,635 (197)

Proenzyme to urokinase‐type plasminogen activator in the mouse in vivo [PDF]

FEBS Letters, 1985
We have investigated whether urokinase‐type plasminogen activator (u‐PA) is present in the mouse in vivo as the proenzyme or as the active enzyme. u‐PA in extracts of various murine tissues was of a one‐polypeptide chain form with an electrophoretic mobility indistinguishable from purified proenzyme (pro‐u‐PA), as demonstrated by SDS‐polyacrylamide gel
Kielberg, V., Andreasen, P.A., Grøndahl-Hansen, J., Nielsen, L.S., Skriver, L., Danø, K.   +5 more
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Nuclear translocation of urokinase-type plasminogen activator

Blood, 2008
AbstractUrokinase-type plasminogen activator (uPA) participates in diverse (patho)physiological processes through intracellular signaling events that affect cell adhesion, migration, and proliferation, although the mechanisms by which these occur are only partially understood. Here we report that upon cell binding and internalization, single-chain uPA (
Victoria, Stepanova, Tatiana, Lebedeva, Alice, Kuo, Serge, Yarovoi, Sergei, Tkachuk, Sergei, Zaitsev, Khalil, Bdeir, Inna, Dumler, Michael S, Marks, Yelena, Parfyonova, Vsevolod A, Tkachuk, Abd Al-Roof, Higazi, Douglas B, Cines   +12 more
openaire   +3 more sources

Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer - correlation with traditional prognostic factors

Radiology and Oncology, 2015
Background. Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients ...
Lampelj Maja, Arko Darja, Cas-Sikosek Nina, Kavalar Rajko, Ravnik Maja, Jezersek-Novakovic Barbara, Dobnik Sarah, Dovnik Nina Fokter, Takac Iztok   +8 more
doaj   +1 more source

The chicken urokinase-type plasminogen activator gene

Fibrinolysis, 1989
The chicken urokinase-type plasminogen activator (uPA) cDNA and gene have been isolated and the complete nucleotide sequence of each established. cDNA sequence and Northern blot RNA analysis indicate that the chicken uPA mRNA is approximately 2500 nucleotides in size and contains a large 3'-noncoding region (998 nucleotides).
N D, Leslie, C A, Kessler, S M, Bell, J L, Degen   +3 more
openaire   +2 more sources

Plasminogen Mediates the Pathological Effects of Urokinase-Type Plasminogen Activator Overexpression [PDF]

The American Journal of Pathology, 2004
Increased expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) is associated with different pathological conditions. Both uPAR-mediated signaling and plasmin-catalyzed extracellular proteolysis may contribute to pathogenesis.
Bolon, Isabelle, Zhou, Hong-Ming, Charron, Yves, Wohlwend, Annelise Isabelle, Vassalli, Jean-Dominique   +4 more
openaire   +3 more sources

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines

Journal of Neuroinflammation, 2019
Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias, Elisabetta Mantuano   +8 more
doaj   +1 more source

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

BMC Ophthalmology, 2012
Background Corneal ulceration leading to perforation is associated with infectious and non-infectious destructive conditions in the cornea. The fibrinolytic (plasminogen/plasmin) system is considered to contribute to tissue remodeling in the wound ...
Sugioka Koji, Kodama Aya, Yoshida Koji, Okada Kiyotaka, Fukuda Masahiko, Shimomura Yoshikazu   +5 more
doaj   +1 more source

Prognostic effects of SuPAR and Neopterin Levels on Patients with Lung Cancer

Pteridines, 2020
Background: Two unique biomarkers, soluble form of the urokinase-type plasminogen activator receptor (suPAR) and neopterin, play a crucial role in inflammatory processes.
Yalcin Selim, Demir Mehmet Emin, Ozturk Reyhan, Kılınç Aytün Şadan, Suer Hatice, Karahan Irfan   +5 more
doaj   +1 more source

Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects. [PDF]

PLoS ONE, 2015
Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen ...
Christoph A Reichel, Maximilian E T Hessenauer, Kerstin Pflieger, Markus Rehberg, Sandip M Kanse, Stefan Zahler, Fritz Krombach, Alexander Berghaus, Sebastian Strieth   +8 more
doaj   +1 more source