Results 21 to 30 of about 23,635 (197)
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Crystal structure and cellular functions of uPAR dimer
Nature Communications, 2022 The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu +9 more
doaj +1 more source
Düzce Tıp Fakültesi Dergisi, 2021 Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt +6 more
doaj +1 more source
Brain Hemorrhages, 2020 Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study.
Zhe Kang Law +5 more
doaj +1 more source
Role of multidomain structure of urokinase in regulation of growth and remodeling of vessels [PDF]
The Ukrainian Biochemical Journal, 2013 Urokinase type plasminogen activator, or urokinase (uPA), is a multifunctional protein which plays special regulatory role in the vascular wall and can actuate the proteolytic and signal cascades.
V. A. Tkachuk +3 more
doaj +1 more source
Characterization of the murine plasminogen/urokinase‐type plasminogen‐activator system [PDF]
European Journal of Biochemistry, 1996 The murine plasminogen/urokinase‐type plasminogen‐activator (u‐PA) system was studied using purified proteins, plasma and endothelioma cells. Recombinant murine u‐PA was obtained as a single‐chain molecule of 45 kDa which was converted to two‐chain u‐PA with plasmin by cleavage of the Lys159‐Ile1 60 peptide bond.
H R, Lijnen, B, Van Hoef, D, Collen
openaire +2 more sources
Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis
Haematologica, 2012 Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation.Design and Methods Circulating microparticles ...
Romaric Lacroix +14 more
doaj +1 more source
Tyrosine phosphorylation of human urokinase‐ type plasminogen activator [PDF]
FEBS Letters, 1991 Immunoblatting analysis of purified human urokinase plasminogen activator (u‐PA), gives a positive signal when reacted with anti‐phosphotyrosine monoclonal antibodies (MoAb anti P‐Tyr); competition with α‐phospha‐DL‐tyrosine (P‐Tyr) but not α‐phosphia‐DL‐threonine or serine (P‐Treo, P‐Ser) completely suppresses this signal.
BARLATI, Sergio +3 more
openaire +3 more sources
Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy
Кардиоваскулярная терапия и профилактика, 2021 The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina +5 more
doaj +1 more source
Multiparity upregulates placental plasminogen and urokinase‐type plasminogen activator
American Journal of Reproductive Immunology, 2017 ProblemMultiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent.
María E. Cortina +3 more
openaire +3 more sources