Results 1 to 10 of about 8,317,164 (175)
Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils via Mac-1, but Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]
Circulation, 2011 Background— Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear. Methods and Results— Using in vivo microscopy on the mouse cremaster muscle, I/R-elicited ...
Johanna Pachmayr +2 more
exaly +6 more sources
Medical Journal of Babylon, 2023 Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj +1 more source
The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis
Frontiers in Immunology, 2022 Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou +15 more
doaj +1 more source
Düzce Tıp Fakültesi Dergisi, 2021 Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt +6 more
doaj +1 more source
Romanian Journal of Laboratory Medicine, 2021 Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj +1 more source
Crystal structure and cellular functions of uPAR dimer
Nature Communications, 2022 The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu +9 more
doaj +1 more source
The structure of the urokinase-type plasminogen activator receptor gene [PDF]
Blood, 1994 The cellular receptor for urokinase-type plasminogen activator (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a central role in pericellular plasminogen activation. It contains 313 amino acid residues, including 28 cysteine residues in a pattern of three homologous repeats. The cysteine residue pattern suggests that
J R, Casey +4 more
openaire +3 more sources
Urokinase-Type Plasminogen Activator Receptor: A Beacon of Malignancy? [PDF]
Clinical Cancer Research, 2008 Abstract Discriminating between benign and malignant disease is a pivotal diagnostic issue in the care of women with pelvic masses. Identification of serum biomakers that can rellably make the distinction would aid in the proper referral for patient care and may provide leads in the development of early detection strategies.
Ronny, Drapkin +2 more
openaire +2 more sources
Communications Biology, 2021 Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans.
Joseph Dowsett +29 more
doaj +1 more source
Oncology Letters, 2017 The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previously been investigated.
Hong, Guo +6 more
openaire +3 more sources