Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]
, 2003 Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R. +19 more
core +2 more sources
Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer
Journal of Translational Medicine, 2022 Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels in malignant tumours.
Bing-Tao Zhai +8 more
doaj +1 more source
Ligand Binding Regions in the Receptor for Urokinase-type Plasminogen Activator [PDF]
Journal of Biological Chemistry, 2001 The interaction between urokinase plasminogen activator (uPA) and its cellular receptor (uPAR) is a key event in cell surface-associated plasminogen activation, relevant for cell migration and invasion. In order to define receptor recognition sites for uPA, we have expressed uPAR fragments as fusion products with the minor coat protein on the surface ...
O D, Liang +3 more
openaire +2 more sources
Expression of Urokinase-type Plasminogen Activator and Its Receptor in Keloids [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2003 The urokinase-mediated plasminogen activation (uPA) system plays a central role in a number of cellular processes including tissue remodeling, cell migration, and angiogenesis. Elevated uPA activity has also been seen with tumor invasion and metastasis in a variety of malignancies.
Deirdre, Leake +2 more
openaire +2 more sources
Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]
, 2003 The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Fuchs, T., Allgayer, H.
core +1 more source
Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer [PDF]
, 1998 The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients.
Beyer, Bianca C. M. +6 more
core +1 more source
Acta Medica Iranica, 2022 Breast cancer is the most common malignant tumor in women. Some factors, including histological grade, vascular invasion, and metastasis, are known prognostic factors.
Ata Abbasi +2 more
doaj +1 more source
The urokinase‐type‐plasminogen‐activator receptor (CD87) is a pleiotropic molecule [PDF]
European Journal of Biochemistry, 1998 Since its discovery over a decade ago, evidence has accumulated implicating the cell‐surface urokinase receptor (u‐PAR), in numerous biological processes. Most notable has been the identification of a critical role for u‐PAR in the regulation of cell‐surface plasminogen activation in physiological and pathological conditions.
A E, Dear, R L, Medcalf
openaire +2 more sources
Urokinase type plasminogen activator receptor expression in colorectal neoplasms [PDF]
Gut, 1998 Background —The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis. Aims —To study the involvement of uPAR in colorectal carcinogenesis.
S, Suzuki +11 more
openaire +2 more sources
Soluble Urokinase-Type Plasminogen Activator Receptor in FSGS [PDF]
Journal of the American Society of Nephrology, 2014 The soluble urokinase-type plasminogen activator receptor (suPAR) has been proposed as a candidate circulating factor causing FSGS.[1][1] In this issue of JASN , Cathelin et al. further examine the short-term effects of two different types of suPAR on the kidney filtration barrier.[2][2 ...
Jochen, Reiser, Harold, Chapman
openaire +2 more sources