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The X-ray Crystal Structure of Full-Length Human Plasminogen
Cell Reports, 2012 Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating plasminogen, which comprises a Pan-apple (PAp) domain, five kringle domains (KR1-5), and a serine protease (SP) domain, adopts a closed, activation-resistant
Ruby H.P. Law +13 more
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Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. [PDF]
PLoS ONE, 2011 BACKGROUND:Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.
Qun Li +8 more
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Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface [PDF]
The Ukrainian Biochemical Journal, 2019 Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin polymerization centers, and initiators of clot retraction, while their ability to modulate clot dissolution remains less understood.
T. Grinenko +4 more
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A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. [PDF]
PLoS Pathogens, 2013 Recruitment of the serine protease plasmin is central to the pathogenesis of many bacterial species, including Group A streptococcus (GAS), a leading cause of morbidity and mortality globally.
Martina L Sanderson-Smith +9 more
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Phosphorylation of human plasminogen activators and plasminogen [PDF]
FEBS Letters, 1995 Plasminogen (PG), urokinase‐type plasminogen activator (u‐PA) and tissue‐type PA (t‐PA) are the main molecules involved in fibrinolysis and in many other physiological and pathological processes. In the present study we report that human t‐PA, purified from human melanoma cells, and PG, purified from human plasma, both contain P‐Tyr residues, as ...
BARLATI, Sergio +4 more
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Contribution of plasminogen activation towards the pathogenic potential of oral streptococci. [PDF]
PLoS ONE, 2010 Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae.
Andreas Itzek +6 more
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Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy
Кардиоваскулярная терапия и профилактика, 2021 The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina +5 more
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Annals of Cardiac Anaesthesia, 2020 Prosthetic valve thrombosis (PVT) is a rare but life-threatening complication. It has an incidence of 6.1% in developing countries and 0.3%–1.3% in developed countries.
Hasan Haghaninejad +2 more
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Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi
Frontiers in Cardiovascular Medicine, 2023 Thrombi are heterogenous in nature with composition and structure being dictated by the site of formation, initiating stimuli, shear stress, and cellular influences. Arterial thrombi are historically associated with high platelet content and more tightly
Anuj Narwal +2 more
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Fibrinolysis and bleeding of unknown cause
Research and Practice in Thrombosis and Haemostasis, 2021 Patients with bleeding of unknown cause (BUC) present with a variety of mild to moderate bleeding symptoms, but no hemostatic abnormalities can be found. Hyperfibrinolysis is rarely evaluated as the underlying cause for bleeding in clinical practice, and
Dino Mehic +3 more
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