Results 1 to 10 of about 13,552 (164)

Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation [PDF]

Molecules, 2019
In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase.
Jyh-Ping Chen, Yunn-Hwa Ma, Chen Jyh-Ping   +2 more
exaly   +4 more sources

Premature delivery impacts the concentration of plasminogen activators and a plasminogen activator inhibitor and the plasmin activity in human milk [PDF]

Frontiers in Pediatrics, 2022
Background and aimsPlasmin in human milk partially hydrolyzes milk proteins within the mammary gland and may enhance the hydrolysis of milk proteins within the infant’s stomach. This study examined the effects of extremely preterm (EP)-, very preterm (VP)
Veronique Demers-Mathieu, Mark A. Underwood, David C. Dallas   +2 more
doaj   +2 more sources

Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1 [PDF]

Data in Brief, 2016
Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Lihu Gong, Min Liu, Tu Zeng, Xiaoli Shi, Cai Yuan, Peter A. Andreasen, Mingdong Huang   +6 more
doaj   +2 more sources

Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
Ilaria De Simone, Kieran Pocknell, Samia Tufaha, Joke Konings, Mark Roest, Alisa S. Wolberg, Claire S. Whyte, Nicola J. Mutch, Bas de Laat, Dana Huskens   +9 more
doaj   +2 more sources

Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. [PDF]

PLoS ONE, 2011
BACKGROUND:Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.
Qun Li, Fang Ke, Weiwei Zhang, Xiaoyan Shen, Qiannan Xu, Hong Wang, Xue-Zhong Yu, Qibin Leng, Honglin Wang   +8 more
doaj   +1 more source

Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface [PDF]

The Ukrainian Biochemical Journal, 2019
Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin polymerization centers­, and initiators of clot retraction, while their ability to modulate clot dissolution remains less understood.
T. Grinenko, О. Yusova, O. Revka, I. Patalakh, T. Yatsenko   +4 more
doaj   +1 more source

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. [PDF]

PLoS Pathogens, 2013
Recruitment of the serine protease plasmin is central to the pathogenesis of many bacterial species, including Group A streptococcus (GAS), a leading cause of morbidity and mortality globally.
Martina L Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Marie Ranson, Victoria A Ploplis, Mark J Walker, Francis J Castellino   +9 more
doaj   +1 more source

Phosphorylation of human plasminogen activators and plasminogen [PDF]

FEBS Letters, 1995
Plasminogen (PG), urokinase‐type plasminogen activator (u‐PA) and tissue‐type PA (t‐PA) are the main molecules involved in fibrinolysis and in many other physiological and pathological processes. In the present study we report that human t‐PA, purified from human melanoma cells, and PG, purified from human plasma, both contain P‐Tyr residues, as ...
BARLATI, Sergio, DE PETRO, Giuseppina, BONA C, PARACINI F, TONELLI M.   +4 more
openaire   +3 more sources

Contribution of plasminogen activation towards the pathogenic potential of oral streptococci. [PDF]

PLoS ONE, 2010
Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae.
Andreas Itzek, Christine M Gillen, Marcus Fulde, Claudia Friedrichs, Arne C Rodloff, Gursharan S Chhatwal, Daniel Patric Nitsche-Schmitz   +6 more
doaj   +1 more source

Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy

Кардиоваскулярная терапия и профилактика, 2021
The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina, N. R. Sabitova, A. Yu. Efimenko, N. I. Kalinina, J. A. Akopyan, E. V. Semina   +5 more
doaj   +1 more source