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New England Journal of Medicine, 1988
TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates +3 more
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TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates +3 more
openaire +2 more sources
Plasminogen activator / plasminogen activator inhibitors in ovarian physiology
Frontiers in Bioscience, 2004The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
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Studies on the kinetics of plasminogen activation by tissue plasminogen activator
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982The steady-state rate of plasminogen activation by tissue plasminogen activator has been determined at various plasminogen concentrations. A plasmin substrate method similar to that presented by Christensen and Müllertz (Biochim. Biophys. Acta 480 (1977) 257-281) was used.
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Plasminogen/plasminogen activator and growth factor activation.
Ciba Foundation symposium, 1997The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin, DB +6 more
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Plasminogen activator inhibitors
Trends in Cardiovascular Medicine, 1991Plasminogen activator inhibitors (PAIs) regulate plasminogen activation in normal and pathologic processes. Plasminogen activator inhibitor 1 (PAI-1) is the major physiologic inhibitor of both tissue-type and urokinase-type plasminogen activators. It is a highly regulated single-chain glycoprotein, whose overexpression in vivo impairs the fibrinolytic ...
J, Schneiderman, D J, Loskutoff
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Plasminogen activators: A comparison
Vascular Pharmacology, 2006Thrombolytic drugs play a crucial role in the management of patients with acute myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis, acute thrombosis of retinal vessel, extensive coronary emboli, and peripheral vascular thromboembolism.
Dev B, Baruah +3 more
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Plasminogen activation and cancer
Thrombosis and Haemostasis, 2005SummaryBreakdown of the extracellular matrix is crucial for cancer invasion and metastasis. It is accomplished by the concerted action of several proteases, including the serine protease plasmin and a number of matrix metalloproteases. The activity of each of these proteases is regulated by an array of activators, inhibitors and cellular receptors ...
Danø, Keld +6 more
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Plasminogen Activators and Angiogenesis
1996The formation of capillaries from preexisting blood vessels (angiogenesis) occurs in a variety of normal and pathological conditions, including organ development, would healing and tumor growth. Angiogenesis requires a strict temporal modulation of opposing cell functions: cell proliferation and migration, and extracellular matrix (ECM) degradation in ...
P, Mignatti, D B, Rifkin
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Plasminogen activator and cancer
European Journal of Cancer and Clinical Oncology, 1984Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of plasminogen activator compared with nontransformed counterparts. This increased synthesis of plasminogen activator may play a role in tumorigenesis, cancer invasion
M J, Duffy, P, O'Grady
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Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system
Biochemistry (Moscow), 2009Angiostatins, kringle-containing fragments of plasminogen, are potent inhibitors of angiogenesis. Effects of three angiostatin forms, K1-3, K1-4, and K1-4.5 (0-2 microM), on the rate of native Glu-plasminogen activation by its physiological activators in the absence or presence of soluble fibrin were investigated in vitro.
R B, Aisina +6 more
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