Results 21 to 30 of about 91,776 (288)
Studies and perspectives of plasminogen activators [PDF]
, 1992 The fibrinolytic system participates in a variety of physiological and pathological processes. It consists of an inactive proenzyme, plasminogen, which can be activated to the active serine protease plasmin by the action of different types of plasminogen
Ernst, B.; University of Rostock +3 more
core +1 more source
Plasminogen activators in acute management of thrombosis
Российский кардиологический журнал, 2013 The paper focuses on the problem of intravascular thrombosis and the methods of its treatment. The data on haemostasis pathophysiology, which underlie the occurrence of acute ischemic events in humans, are presented, together with the data on the action ...
E. O. Taratukhin
doaj +1 more source
Scientific Reports, 2021 Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller +6 more
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Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2
Current Issues in Molecular Biology, 2022 Bat plasminogen activators α2 (DSPAα2) has extremely high medicinal value as a powerful natural thrombolytic protein. However, wild-type DSPAα2 has two N-glycosylation sites (N185 and N398) and its non-human classes of high-mannose-type N-glycans may ...
Huakang Peng +8 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundThe safety and long‐term outcome of systemic thrombolysis in patients receiving antiplatelet medications remain subjects of great clinical significance.
Shengyuan Luo +3 more
doaj +1 more source
Hexa-acylated LPS-lipid A deploys the appropriate level of fibrin to confer protection through MyD88
International Journal of Infectious Diseases, 2015 Objectives: Fibrin has been demonstrated to function protectively against pathogens in our previous studies, but we observed that a very high level of fibrin played a negative role during infection. We performed this research to address the complication.
Qi Zhao +4 more
doaj +1 more source
Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]
PLoS ONE, 2012 The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
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Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
A novel ex vivo approach for measuring plasminogen activation upon established plasma clots
Research and Practice in Thrombosis and Haemostasis, 2022 Background The fibrinolytic system plays a critical role in maintaining hemostasis. Central to fibrinolysis is the degradation of fibrin by plasmin, produced in the circulation following the activation of plasminogen by plasminogen activators (PAs ...
Jason S. Palazzolo +3 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2000 The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal +5 more
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