Results 21 to 30 of about 13,552 (164)
Hexa-acylated LPS-lipid A deploys the appropriate level of fibrin to confer protection through MyD88
International Journal of Infectious Diseases, 2015 Objectives: Fibrin has been demonstrated to function protectively against pathogens in our previous studies, but we observed that a very high level of fibrin played a negative role during infection. We performed this research to address the complication.
Qi Zhao +4 more
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Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]
PLoS ONE, 2012 The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
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A novel ex vivo approach for measuring plasminogen activation upon established plasma clots
Research and Practice in Thrombosis and Haemostasis, 2022 Background The fibrinolytic system plays a critical role in maintaining hemostasis. Central to fibrinolysis is the degradation of fibrin by plasmin, produced in the circulation following the activation of plasminogen by plasminogen activators (PAs ...
Jason S. Palazzolo +3 more
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Brazilian Journal of Medical and Biological Research, 2000 The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal +5 more
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Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. [PDF]
PLoS ONE, 2012 Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing.
Yue Shen +5 more
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Pathogen activators of plasminogen [PDF]
Journal of Thrombosis and Haemostasis, 2015 Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination.
I M, Verhamme, P R, Panizzi, P E, Bock
openaire +2 more sources
Characterization of plasmin, plasminogen and plasminogen activator in goat milk
Italian Journal of Animal Science, 2011 Plasmin (PL), a serine-proteinase, appears to be the predominant native proteinase in milk and it is mainly associated to casein micelles which represent its substrate (Bastian and Brown, 1996). Plasmin occurs in milk together with its inactive zymogene,
F. Polidori +3 more
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Activation of Plasminogen by Staphylokinase [PDF]
Nature, 1960 SOME animal plasminogens, which are unaffected by streptokinase alone, are activated by streptokinase and human globulin. Mullertz1 has postulated the existence of a proactivator in human serum. Staphylokinase, without human globulin, activates a wider range of animal plasminogens2 and may, therefore, not require proactivator.
openaire +2 more sources
Brazilian Journal of Medical and Biological Research, 1997 We cloned the streptokinase (STK) gene of Streptococcus equisimilis in an expression vector of Escherichia coli to overexpress the profibrinolytic protein under the control of a tac promoter. Almost all the recombinant STK was exported to the periplasmic
L. Avilán +5 more
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Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
Computational and Structural Biotechnology Journal, 2022 Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type.
Dmitri Nikitin +12 more
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