Results 31 to 40 of about 91,776 (288)

Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. [PDF]

PLoS ONE, 2012
Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing.
Yue Shen, Yongzhi Guo, Chun Du, Malgorzata Wilczynska, Sten Hellström, Tor Ny   +5 more
doaj   +1 more source

Characterization of plasmin, plasminogen and plasminogen activator in goat milk

Italian Journal of Animal Science, 2011
Plasmin (PL), a serine-proteinase, appears to be the predominant native proteinase in milk and it is mainly associated to casein micelles which represent its substrate (Bastian and Brown, 1996). Plasmin occurs in milk together with its inactive zymogene,
F. Polidori, G. Lebbroni, P. Polidori, F. Fantuz   +3 more
doaj   +1 more source

Pathogen activators of plasminogen [PDF]

Journal of Thrombosis and Haemostasis, 2015
Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination.
I M, Verhamme, P R, Panizzi, P E, Bock
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cloning, expression and purification of recombinant streptokinase: partial characterization of the protein expressed in Escherichia coli

Brazilian Journal of Medical and Biological Research, 1997
We cloned the streptokinase (STK) gene of Streptococcus equisimilis in an expression vector of Escherichia coli to overexpress the profibrinolytic protein under the control of a tac promoter. Almost all the recombinant STK was exported to the periplasmic
L. Avilán, A. Yarzábal, C. Jürgensen, M. Bastidas, J. Cruz, J. Puig   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mechanism of Action of Plasminogen Activators

, 1999
IntroductionAcute coronary ischemic syndromes and stroke are usually caused by thrombosis in arteries where obstruction leads to ischemia of the heart or brain, respectively.
Jeffrey Weitz, James Fredenburgh, Ronald Stewart   +2 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

Computational and Structural Biotechnology Journal, 2022
Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type.
Dmitri Nikitin, Jan Mican, Martin Toul, David Bednar, Michaela Peskova, Patricia Kittova, Sandra Thalerova, Jan Vitecek, Jiri Damborsky, Robert Mikulik, Sarel J. Fleishman, Zbynek Prokop, Martin Marek   +12 more
doaj   +1 more source

Activation of Plasminogen by Staphylokinase [PDF]

Nature, 1960
SOME animal plasminogens, which are unaffected by streptokinase alone, are activated by streptokinase and human globulin. Mullertz1 has postulated the existence of a proactivator in human serum. Staphylokinase, without human globulin, activates a wider range of animal plasminogens2 and may, therefore, not require proactivator.
openaire   +2 more sources