Results 31 to 40 of about 14,970 (304)

Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]

PLoS ONE, 2012
The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
doaj   +1 more source

Pathogen activators of plasminogen [PDF]

Journal of Thrombosis and Haemostasis, 2015
Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination.
I M, Verhamme, P R, Panizzi, P E, Bock
openaire   +2 more sources

A novel ex vivo approach for measuring plasminogen activation upon established plasma clots

Research and Practice in Thrombosis and Haemostasis, 2022
Background The fibrinolytic system plays a critical role in maintaining hemostasis. Central to fibrinolysis is the degradation of fibrin by plasmin, produced in the circulation following the activation of plasminogen by plasminogen activators (PAs ...
Jason S. Palazzolo, Robert L. Medcalf, Christoph E. Hagemeyer, Be'eri Niego   +3 more
doaj   +1 more source

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Mairuhu, A. T. A., Hack, C. E., Leyte, A, Osterhaus, A.D.M.E. (Albert), Koraka, P. (Penelope), Brandjes, D.P.M. (Dees), Mairuhu, A.T., ten Cate H, Brandjes, D.P., SMH Faradz, Faradz, S.M.H., van Gorp, E., Hack, C. Erik, Setiati, T., Brandjes DPM, Mairuhu, ATA, Osterhaus ADME, Setiati, T. E., Reitsma, PH, Osterhaus, A.D.M.E., Faradz, SMH, Faradz SMH, Gorp, E. van, Brandjes, D. P. M., van Gorp, E. C. M., Faradz, Sultana M.H., Setiati, T.E. (Tatty), Brandjes, D.P.M., Osterhaus, A.D., Setiati, Tatty E., van Gorp, E.C.M., Cate, H. (Hugo) ten, Koraka, P., Reitsma PH, van Gorp, Eric, Mairuhu, A.T.A., Mairuhu ATA, Reitsma, P., ECM van Gorp, Koraka, Penelopie, Reitsma, P.H., A Leyte, Setiati, TE, van Gorp, Eric C. M., Setiati TE, Osterhaus, Ab, Koraka, P, Leyte A, H ten Cate, ADME Osterhaus, Osterhaus, A. D. M. E., Hack CE, PH Reitsma, Setiati, T.E., Hack, C.E., Osterhaus, ADME, Faradz, S. M. H., CE Hack, Reitsma, P. H., van Gorp ECM, ATA Mairuhu, Osterhaus, A., TE Setiati, Koraka P, Leyte, A. (Anja), P Koraka, Mairuhu, A., Faradz, S.M.H. (Sultana), Gorp, E.C.M. (Eric) van, Hack, CE, DPM Brandjes, Hack, C., Faradz, S., Cate, H. Ten, Hack, C.E. (Erik), ten Cate, H., Leyte, A.   +78 more
core   +1 more source

Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. [PDF]

PLoS ONE, 2012
Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing.
Yue Shen, Yongzhi Guo, Chun Du, Malgorzata Wilczynska, Sten Hellström, Tor Ny   +5 more
doaj   +1 more source

A study of the interaction between Helicobacter pylori and components of the human fibrinolytic system

Brazilian Journal of Medical and Biological Research, 2000
The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal, L. Avilán, K. Hoelzl, M. de Muñoz, J. Puig, I. Kansau   +5 more
doaj   +1 more source

Mechanism of Action of Plasminogen Activators

, 1999
IntroductionAcute coronary ischemic syndromes and stroke are usually caused by thrombosis in arteries where obstruction leads to ischemia of the heart or brain, respectively.
Jeffrey Weitz, James Fredenburgh, Ronald Stewart   +2 more
core   +1 more source

Characterization of plasmin, plasminogen and plasminogen activator in goat milk

Italian Journal of Animal Science, 2011
Plasmin (PL), a serine-proteinase, appears to be the predominant native proteinase in milk and it is mainly associated to casein micelles which represent its substrate (Bastian and Brown, 1996). Plasmin occurs in milk together with its inactive zymogene,
F. Polidori, G. Lebbroni, P. Polidori, F. Fantuz   +3 more
doaj   +1 more source

Activation of Plasminogen by Staphylokinase [PDF]

Nature, 1960
SOME animal plasminogens, which are unaffected by streptokinase alone, are activated by streptokinase and human globulin. Mullertz1 has postulated the existence of a proactivator in human serum. Staphylokinase, without human globulin, activates a wider range of animal plasminogens2 and may, therefore, not require proactivator.
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source