Results 51 to 60 of about 14,970 (304)

Studies with plasminogen activators [PDF]

, 1965
In the past decade, stimulated by the availability of fibrinolytic agents suitable for use in man in the treatment of thrombo-embolic vascular occlusion, there has been a great increase in interest in the components and functions of the fibrinolytic ...
McNicol, George P
core  

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

Haematologica, 2012
Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation.Design and Methods Circulating microparticles ...
Romaric Lacroix, Laurent Plawinski, Stéphane Robert, Loïc Doeuvre, Florence Sabatier, Sara Martinez de Lizarrondo, Anna Mezzapesa, Francine Anfosso, Aurelie S. Leroyer, Pascale Poullin, Noémie Jourde, Makon-Sébastien Njock, Chantal M. Boulanger, Eduardo Anglés-Cano, Françoise Dignat-George   +14 more
doaj   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source

Plasminogen activators are involved in angiostatin generation in vivo in benign and malignant ovarian tumor cyst fluids [PDF]

, 2014
Contains fulltext : 136532.pdf (Publisher’s version ) (Open Access)In many tumor types, angiogenesis is the net result of pro- and anti-angiogenic mediators and correlated with metabolic activity, growth, and degree of malignancy.
Geurts-Moespot, A., Massuger, L.F.A.G., Wetzels, A.M.M., Tilborg, A.G. van, Sweep, C.G.J., Waal, R.M.W. de, Westphal, J.R.   +6 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Streptolysin O accelerates the conversion of plasminogen to plasmin

Nature Communications
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Di Tang, Hamed Khakzad, Elisabeth Hjortswang, Lars Malmström, Simon Ekström, Lotta Happonen, Johan Malmström   +6 more
doaj   +1 more source

Activators and inhibitors of the plasminogen system in Alzheimer's disease

, 2012
Accumulation and deposition of Aβ is one of the main neuropathological hallmarks of Alzheimer's disease (AD) and impaired Aβ degradation may be one mechanism of accumulation.
Barker, Rachel, Seth Love, Love, Seth, Patrick G. Kehoe, Rachel Barker, Kehoe, Patrick G   +5 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment

Pharmaceutics
Plasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circulation.
Ming-Lu Lin, Siao-Yun Wu, Jyh-Ping Chen, Yi-Ching Lu, Shih-Ming Jung, Shiaw-Pyng Wey, Tony Wu, Yunn-Hwa Ma   +7 more
doaj   +1 more source