Results 51 to 60 of about 91,776 (288)
Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment
PharmaceuticsPlasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circulation.
Ming-Lu Lin +7 more
doaj +1 more source
Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease
Research and Practice in Thrombosis and Haemostasis, 2020 The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (APR ...
Breanne H.Y. Gibson +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai +13 more
wiley +1 more source
Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution
Advanced Healthcare Materials, EarlyView.Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk +6 more
wiley +1 more source
Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis
Journal of Intensive Care, 2017 Background Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis.
Toshiaki Iba, Jecko Thachil
doaj +1 more source
Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots
Advanced Robotics Research, EarlyView.This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou +4 more
wiley +1 more source
Plasminogen–receptor KT: plasminogen activation and beyond [PDF]
Journal of Thrombosis and Haemostasis, 2017 The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-RKT, a key plasminogen receptor expressed in numerous tissues, but highly expressed by ...
M J, Flick, T H, Bugge
openaire +2 more sources
, 2021 Plasminogen activators cleave the zymogen plasminogen to form the serine protease, plasmin. The fibrinolytic enzyme plasmin breaks the cross-links between fibrin molecules, which are the structural support of the blood clot generating fibrin degradation ...
Sajad Rashidi Monfared (5579429) +3 more
core +1 more source
Advanced Robotics Research, EarlyView.Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin +3 more
wiley +1 more source
Effect of plasminogen activators on the promotion of RSV-induced cell transformation.
, 1985 Effect of plasminogen activators on the promotion of RSV-induced cell ...
Salonen E. +4 more
core +1 more source