Results 71 to 80 of about 28,516 (205)

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Clinical and Translational Medicine, 2018
Background Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking.
Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh, Steven Idell   +15 more
doaj   +1 more source

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer [PDF]

, 2017
Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity.
A H Allam, A Neesse, A Neesse, A V Biankin, A Xue, AB Seymour, AD Rhim, AK Witkiewicz, AM LeBeau, AR Shekouh, AV Biankin, B Hinz, BC Ozdemir, BJ Cochran, BJ Cochran, C Gaggioli, C Vennin, D Croucher, D Goldstein, D Herrmann, D Herrmann, D Mahadevan, D N Saunders, D Telgenhoff, DD Von Hoff, DR Croucher, DR Croucher, E Cerami, F Al-Ejeh, G Finak, H Shiomi, HW Smith, I Garrido-Laguna, J Condeelis, J Gao, J Gore, J Lee, J Li, J P Morton, J R W Conway, JA Lee, JJ Lee, JP Morton, K Kessenbrock, K L Vine, L Harris, M C Lucas, M J Cowley, M Nobis, M Pajic, M Pinese, M Ranson, MJ Duffy, ML Nyström, N L E Harris, N Waddell, P Bailey, P Carmeliet, P Timpson, P Timpson, R Cicchi, R F Shearer, R Kalluri, R Smith, RF Shearer, RG Rowe, RL Siegel, S Nurmenniemi, S Ulisse, SC Barry, SR Hingorani, SR Hingorani, TK Stutchbury, WA Schroder, Y Takeuchi, ZS Boyd, Ö Babur   +76 more
core   +1 more source

Yersinia pestis Plasminogen Activator

Biomolecules, 2020
The Gram-negative bacterium Yersinia pestis causes plague, a fatal flea-borne anthropozoonosis, which can progress to aerosol-transmitted pneumonia. Y. pestis overcomes the innate immunity of its host thanks to many pathogenicity factors, including plasminogen activator, Pla.
Florent Sebbane, Vladimir N. Uversky, Andrey P. Anisimov   +2 more
openaire   +4 more sources

The role of the fibrinolytic system in female reproductive disorders and depression

Thrombosis Update, 2020
Tissue plasminogen activator (tPA) and urinary plasminogen activator (uPA or urokinase) have important functions in the extracellular matrix. In the reproductive system, for example, tPA and uPA mediate tissue remodeling required for ovulation ...
Silvia Hoirisch-Clapauch, Benjamin Brenner   +1 more
doaj   +1 more source

Contribution of macrophages to plasmin activity in ewe bulk milk

Italian Journal of Animal Science, 2010
A total of 225 bulk sheep milk samples were collected throughout lactation to assess the contribution of macrophages to the regulation of the plasmin/plasminogen system. Samples were analyzed for composition, milk renneting parameters, and for activities
M. Albenzio, A. Sevi, A. Marzano, R. Marino, L. Schena, M. Caroprese   +5 more
doaj   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles

TH Open
Plasminogen activator inhibitor type 1 (PAI-1) is the key regulator of the fibrinolytic system, thereby acting as a potent mediator in thrombosis. Plasminogen activators such as PAI-1 mediate the conversion of the inactive zymogen plasminogen to plasmin,
Jacob Wortley, Justin Vu, Neha Soogoor, Mebeli Becerra, Mohanakrishnan Sathyamoorthy   +4 more
doaj   +1 more source

Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

The Ukrainian Biochemical Journal, 2018
The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-I), in patients with stage ...
O. I. Yusova, O. V. Savchuk, T. V. Grinenko, O. B. Kuchmenko, L. S. Mhitaryan, O. H. Kupchins’ka, I. N. Yevstratova, O. O. Matova, N. M. Vasilinchuk, T. F. Drobot’ko   +9 more
doaj   +1 more source

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

Brain Hemorrhages, 2020
Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study.
Zhe Kang Law, Michael Desborough, Kamini Rakkar, Philip M. Bath, Ulvi Bayraktutan, Nikola Sprigg   +5 more
doaj   +1 more source

The factor VII activating protease G511E (Marburg) variant and cardiovascular risk [PDF]

, 2004
A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a ...
Cooper, J.A., Humphries, S.E., Ireland, H., Miller, G.J., Webb, K.E.   +4 more
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