Results 1 to 10 of about 579,513 (302)

Tissue Plasminogen Activator [PDF]

New England Journal of Medicine, 1989
Coronary thrombolysis has been proved to be beneficial in the treatment of myocardial infarction. Much attention has been focused on tissue-type plasminogen activator (t-PA) as a fibrinolytic agent. This article will discuss the unique properties of t-PA and the role of the critical care nurse in providing the safe delivery of t-PA.
Linda Lindsay, M. Cataletto
semanticscholar   +8 more sources

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

Scientific Reports, 2021
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients.
Yu Zuo, Mark Warnock, Alyssa Harbaugh, Srilakshmi Yalavarthi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Jason S. Knight, Yogendra Kanthi, Daniel A. Lawrence   +9 more
doaj   +2 more sources

The Neurotoxicity of Tissue Plasminogen Activator? [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2004
Tissue plasminogen activator (tPA), a fibrin specific activator for the conversion of plasminogen to plasmin, stimulates thrombolysis and rescues ischemic brain by restoring blood flow. However, emerging data suggests that under some conditions, both tPA and plasmin, which are broad spectrum protease enzymes, are potentially ...
Alastair M Buchan, Eng Lo
exaly   +4 more sources

The tissue-type plasminogen activator–plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Brain, 2012
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is
Robert Medcalf, Catriona Mclean, André L Samson   +2 more
exaly   +2 more sources

Treatment With Tissue Plasminogen Activator in the Golden Hour and the Shape of the 4.5-Hour Time-Benefit Curve in the National United States Get With The Guidelines-Stroke Population

Circulation, 2017
Jeffrey Saver, , James Grotta
exaly   +2 more sources

Incidence of Hemorrhagic Complications among Patients Treated with Thrombolytic in Erbil City, Iraq [PDF]

Al-Anbar Medical Journal, 2020
Background: Recombinant tissue-type plasminogen activator is an option of treatment for suspected occlusive vascular thrombi and its sequel (transmural myocardial infarction, pulmonary embolism, and ischemic stroke). The most important concern associated
Ahmed F. Hammad, Imad T. Abdulhafed, Abdulsalam R. Awad   +2 more
doaj   +1 more source

Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model. [PDF]

PLoS ONE, 2014
BACKGROUND: The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control.
Kristina Svennerholm, Niklas Bergh, Pia Larsson, Sverker Jern, Göran Johansson, Björn Biber, Michael Haney   +6 more
doaj   +1 more source

Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series

Journal of Thrombosis and Haemostasis, 2020
A prothrombotic coagulopathy is commonly found in critically ill COVID‐19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID‐19 respiratory failure is a relatively preserved lung compliance and high Alveolar‐arterial ...
Janice Wang, N. Hajizadeh, E. Moore, R. McIntyre, Peter K. Moore, L. Veress, M. Yaffe, H. Moore, Christopher D. Barrett   +8 more
semanticscholar   +1 more source

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

medRxiv, 2020
Background: Patients with coronavirus disease 19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions, while lung histopathology often reveals fibrin-based occlusion of small vessels in patients who succumb to the disease.
Y. Zuo, M. Warnock, Alyssa Harbaugh, S. Yalavarthi, K. Gockman, M. Zuo, J. Madison, J. Knight, Y. Kanthi, D. Lawrence   +9 more
semanticscholar   +1 more source

Peripheral embolization following thrombolytic therapy for acute ischemic stroke—a case report

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020
Background Intravenous recombinant tissue plasminogen activator is the only golden approved medical therapy for acute ischemic stroke, guidelines for its injection relay on reducing or preventing associated hemorrhage as a side effect, yet hemorrhage is ...
Tamer Roushdy, Eman Hamid, Mai Fathy, Islam Bastawy, Hany Aref, Nevine El Nahas   +5 more
doaj   +1 more source