Results 31 to 40 of about 2,071,373 (281)

Protective role of N-acetylcysteine and Sulodexide on endothelial cells exposed on patients’ serum after SARS-CoV-2 infection

Frontiers in Cellular and Infection Microbiology, 2023
Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and, as a result, aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage.
Justyna Rajewska-Tabor, Patrycja Sosińska-Zawierucha, Malgorzata Pyda, Maciej Lesiak, Andrzej Bręborowicz, Andrzej Bręborowicz   +5 more
doaj   +1 more source

Neuroimmunomodulatory effects of transcranial laser therapy combined with intravenous tPA administration for acute cerebral ischemic injury

Neural Regeneration Research, 2015
At present, the only FDA approved treatment for ischemic strokes is intravenous administration of tissue plasminogen activator within 4.5 hours of stroke onset.
Philip V Peplow
doaj   +1 more source

Orolingual angioedema as a complication of systemic thrombolytic therapy with recombinant tissue plasminogen activator

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2023
Orolingual angioedema is a rare, but extremely dangerous complication of systemic thrombolytic therapy with recombinant tissue plasminogen activator, the incidence of which reaches 2.2-5.1 %.
E. A. Kovaleva, Kh. V. Korigova, A. I. Vyshlova, E. V. Shevchenko, L. Kh.-B. Akhmatkhanova, G. R. Ramazanov, I. S. Aliev   +6 more
doaj   +1 more source

Tissue Plasminogen Activator in the Lens

Ophthalmic Research, 2009
Biochemical analyses of normal lenses from monkey, dog and calf eyes revealed significant levels of tissue plasminogen activator (t-PA). By immunohistochemistry, a positive reaction product for t-PA was seen, in descending order of staining intensity, in the central epithelium, equatorial epithelium, superficial fibers of the anterior cortex, and ...
B J, Tripathi, R C, Tripathi, J D, Geanon   +2 more
openaire   +2 more sources

Human monocytes can produce tissue-type plasminogen activator [PDF]

, 1989
Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen ...
Vitti, GF, Hamilton, JA, Hart, PH, Singleton, DK, Burgess, DR   +4 more
core   +1 more source

Tissue plasminogen activator for blocked peritoneal dialysis catheters

Tissue plasminogen activator was used for a blocked peritoneal dialysis catheter in a child with no vascular access. The catheter was salvaged using tissue plasminogen activator and dialysis could be carried out without any ...
Krishnan RG, Moghal NE
core   +4 more sources

Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

Neural Regeneration Research
Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage. However, during minimally invasive surgery, recombinant tissue plasminogen activator may come into contact
Jie Jing, Shiling Chen, Xuan Wu, Jingfei Yang, Xia Liu, Jiahui Wang, Jingyi Wang, Yunjie Li, Ping Zhang, Zhouping Tang   +9 more
doaj   +1 more source

Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies [PDF]

Neuroscience, 2010
A growing body of evidence demonstrates the involvement of plasminogen activators (PAs) in a number of physiologic and pathologic events in the CNS. Induction of both tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) has been observed in different experimental models of epilepsy and tPA has been implicated in the mechanisms ...
A. M. Iyer, E. Zurolo, K. Boer, J. C. Baayen, GIANGASPERO, FELICE, A. Arcella, G. C. Di Gennaro, ESPOSITO, Vincenzo, W. G. M. Spliet, P. C. Van Rijen, D. Troost, J. A. Gorter, E. Aronica   +12 more
openaire   +8 more sources

Plasminogen Activator – Multifunctional Protein of Plague Pathogen

Проблемы особо опасных инфекций, 2016
Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure.
L. M. Kukleva, A. V. Boiko
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source