Results 31 to 40 of about 579,513 (302)

Neuroimmunomodulatory effects of transcranial laser therapy combined with intravenous tPA administration for acute cerebral ischemic injury

Neural Regeneration Research, 2015
At present, the only FDA approved treatment for ischemic strokes is intravenous administration of tissue plasminogen activator within 4.5 hours of stroke onset.
Philip V Peplow
doaj   +1 more source

Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies [PDF]

Neuroscience, 2010
A growing body of evidence demonstrates the involvement of plasminogen activators (PAs) in a number of physiologic and pathologic events in the CNS. Induction of both tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) has been observed in different experimental models of epilepsy and tPA has been implicated in the mechanisms ...
A. M. Iyer, E. Zurolo, K. Boer, J. C. Baayen, GIANGASPERO, FELICE, A. Arcella, G. C. Di Gennaro, ESPOSITO, Vincenzo, W. G. M. Spliet, P. C. Van Rijen, D. Troost, J. A. Gorter, E. Aronica   +12 more
openaire   +8 more sources

Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

Neural Regeneration Research
Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage. However, during minimally invasive surgery, recombinant tissue plasminogen activator may come into contact
Jie Jing, Shiling Chen, Xuan Wu, Jingfei Yang, Xia Liu, Jiahui Wang, Jingyi Wang, Yunjie Li, Ping Zhang, Zhouping Tang   +9 more
doaj   +1 more source

Tissue plasminogen activator mRNA in murine tissues [PDF]

FEBS Letters, 1988
The urokinase‐type and tissue‐type plasminogen activators are the two enzymes found in mammals, which specifically convert the zymogen plasminogen to plasmin. Using cDNA probes, we have assayed for the presence of the two types of plasminogen activator mRNAs in murine tissues.
Rickles, Richard J., Strickland, Sidney
openaire   +2 more sources

Plasminogen Activator – Multifunctional Protein of Plague Pathogen

Проблемы особо опасных инфекций, 2016
Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure.
L. M. Kukleva, A. V. Boiko
doaj   +1 more source

Plasminogen Activator from Porcine Heart Tissue

CHIMIA, 1976
By ion exchange chromatography, precipitation with (NH4)2SO4 and gel filtration highly enriched tissue activator of plasminogen is prepared from pig heart tissue. Further purification can be achieved by isoelectric focusing. With the same technique five
P. Cuendet, E.E. Rickli
doaj   +1 more source

Acceleration of Tissue Plasminogen Activator-Mediated Thrombolysis by Magnetically Powered Nanomotors

ACS Nano, 2014
Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments.
Rui Cheng, Weijie Huang, Lijie Huang, Bo Yang, L. Mao, K. Jin, Q. Zhuge, Yiping Zhao   +7 more
semanticscholar   +1 more source

Thrombotic risk markers: tissue plasminogen activator/tissue plasminogen activator inhibitor-1 complex (Part 1)

Вестник анестезиологии и реаниматологии
The fibrinolysis system is one of the most important regulators of homeostasis and participates in maintaining stable blood flow. The key element of this system is the balance of plasminogen activators and inhibitors, which can be considered as markers ...
M. M. Tanashyan, E. V. Roitman, A. A. Raskurazhev, P. I. Kuznetsova, A. S. Mazur   +4 more
doaj   +1 more source

Plasminogen influence on the PAI-1 release by human platelets [PDF]

The Ukrainian Biochemical Journal
РАІ-1 (plasminogen activator inhibitor type 1), as a major physiological inhibitor of tissue plasminogen activator and urokinase, plays a key role in the regulation of fibrinolysis in vivo.
O. I. Yusova , T. V. Grinenko, T. F. Drobot’ko , A. O. Tykhomyrov   +3 more
doaj   +1 more source

Enablers of the implementation of tissue plasminogen activator in acute stroke care: a cross-sectional survey. [PDF]

PLoS ONE, 2014
To assess emergency physicians' perceptions of individual and system enablers to the use of tissue Plasminogen Activator in acute stroke.Australian fellows and trainees of Australasian College for Emergency Medicine completed a 57-item online survey ...
Alice Grady, Jamie Bryant, Mariko Carey, Chris Paul, Rob Sanson-Fisher   +4 more
doaj   +1 more source