Results 91 to 100 of about 14,970 (304)

An immunohistochemical study of the distribution of plasminogen and plasminogen activators in bullous pemphigoid.

, 1993
Abnormalities of the cutaneous plasminogen/plasminogen activator system have been associated with acantholytic disorders, psoriasis, keratinocytes in culture, and epidermis in healing wounds.
Cederholm-Williams, S, Venning, VA, Wojnarowska, F, Wojnarowska, Fenella   +3 more
core   +1 more source

Schematic representation of tissue plasminogen activators (PA) mode of action and functional domains.

, 2021
Plasminogen activators cleave the zymogen plasminogen to form the serine protease, plasmin. The fibrinolytic enzyme plasmin breaks the cross-links between fibrin molecules, which are the structural support of the blood clot generating fibrin degradation ...
Sajad Rashidi Monfared (5579429), Mokhtar Jalali Javaran (11772661), Alexandra Castilho (199752), Shiva Izadi (11102286)   +3 more
core   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles

TH Open
Plasminogen activator inhibitor type 1 (PAI-1) is the key regulator of the fibrinolytic system, thereby acting as a potent mediator in thrombosis. Plasminogen activators such as PAI-1 mediate the conversion of the inactive zymogen plasminogen to plasmin,
Jacob Wortley, Justin Vu, Neha Soogoor, Mebeli Becerra, Mohanakrishnan Sathyamoorthy   +4 more
doaj   +1 more source

Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

The Ukrainian Biochemical Journal, 2018
The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-I), in patients with stage ...
O. I. Yusova, O. V. Savchuk, T. V. Grinenko, O. B. Kuchmenko, L. S. Mhitaryan, O. H. Kupchins’ka, I. N. Yevstratova, O. O. Matova, N. M. Vasilinchuk, T. F. Drobot’ko   +9 more
doaj   +1 more source

Heat inactivation of native plasmin, plasminogen and plasminogen activators in bovine milk: a revisited study

, 2001
International audienceThermal inactivation, at temperatures between 60 °C and 140 °C, of native plasmin, plasminogen and plasminogen activators were studied in bovine milk using improved enzymatic assays.
Denis, Thierry, Humbert, Gérard, Gaillard, Jean-Luc   +2 more
core   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Analysis of fibronectin, plasminogen activators and plasminogen/plasmin in tear fluid as markers of corneal damage and repair

, 1990
Corneal damage of various origins initiates a series of processes which lead to repair but also tend to perpetuate the damage; healing thus depends on the prevalence of repair over progression processes.
SEMERARO, Francesco, QUARANTA CA, BARLATI S, VIGASIO F, MARCHINA, Eleonora   +4 more
core   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Characterization of Plasminogen Activators in Unstimulated and Stimulated Human Whole Saliva

, 1987
The fibrinolytic activity of saliva from healthy males was studied on plasminogen-free and plasminogen-rich fibrin plates. A cell-bound plasminogen activator in human unstimulated and stimulated whole saliva was demonstrated.
Sindet-Pedersen, S., Gram, Jørgen Brodersen, Jespersen, J.; id_orcid   +2 more
core   +2 more sources