Results 91 to 100 of about 28,516 (205)

Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor

BMC Gastroenterology, 2006
Background The urokinase-type (uPA) and tissue-type (tPA) plasminogen activators regulate liver matrix remodelling through the conversion of plasminogen (Plg) to the active protease plasmin.
Bezerra Jorge A, Degen Jay L, Sabla Gregg E, Shanmukhappa Kumar   +3 more
doaj   +1 more source

THE LEVELS OF PLASMINOGEN AND INHIBITOR OF PLASMINOGEN ACTIVATORS OF TYPE 1 IN ANTIPHOSPHOLIPID SYNDROME

Терапевтический архив, 2012
Aim. To estimate the levels of of plasminogen (Pg) and inhibitor of plasminogen activators of type 1 (IPA-1) in patients with antiphospholipid syndrome (APS) and to reveal correlations between their content and clinical-laboratory characteristics of APS.
E V Ostryakova, T M Reshetnyak, R B Aisina, L I Mukhametova, D A Gulin, E N Alexandrova, N V Seredavkina, S D Varfolomeev, A V Chernyakov, Yu V Nikiforov, E L Nasonov   +10 more
doaj  

Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia

Neurobiology of Disease, 2007
Tetracyclines inhibit matrix metalloproteinases (MMPs) and reduce infarction volume following cerebral ischemia. In this thesis an involvement of urokinase could be proven.
Dorothe Burggraf, Andreas Trinkl, Martin Dichgans, Gerhard F. Hamann   +3 more
doaj   +1 more source

Functional Stability of Plasminogen Activator Inhibitor-1

The Scientific World Journal, 2014
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), and a major regulator of the fibrinolytic system.
Songul Yasar Yildiz, Pinar Kuru, Ebru Toksoy Oner, Mehmet Agirbasli   +3 more
doaj   +1 more source

Recombinant Plasminogen Activator of the Sandworm (Perinereis aibuhitensis) Expression in Escherichia coli

Bioengineering
As an essential thrombolytic agent, the tissue plasminogen activator receives increasing attention due to its longer half-life, lower immunogenicity, and easier administration, which are superior to other thrombolytic agents.
Tuo Song, Xiaozhen Diao, Jun Cheng, Yang Man, Boyu Chen, Haixing Zhang, Wenhui Wu   +6 more
doaj   +1 more source

Micrometer‐scale tPA beads amplify plasmin generation for enhanced thrombolytic therapy

Bioengineering & Translational Medicine
Rapid restoration of blood flow is critical in treating acute ischemic stroke. Current thrombolytic therapies using tissue plasminogen activator (tPA) are limited by low recanalization rates and risks of off‐target bleeding.
Matthew J. Osmond, Fabrice Dabertrand, Nidia Quillinan, Enming J. Su, Daniel A. Lawrence, David W. M. Marr, Keith B. Neeves   +6 more
doaj   +1 more source

Collagenase is a major gene product of induced rabbit synovial fibroblasts. [PDF]

, 1984
We have investigated the effects of the tumor-promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA), on rabbit synovial fibroblasts, and found that this agent induced a major switch in gene expression in these cells that was marked by the
Aggeler, J, Frisch, SM, Werb, Z
core  

Microbiological and chemical profiles of dairy farm red smear cheese made from pasteurized and un-pasteurized milk [PDF]

, 2007
A red-smear soft cheese was produced four times during a year at an organic dairy farm using pasteurized and un-pasteurized milk, respectively, from the same milking. A commercial starter culture was added.
Hammershøj, M., Hansen, T.B., Højgaard, K.S., Knøchel, S., Larsen, L.B., Nielsen, J.H.   +5 more
core  

Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors. [PDF]

J Biol Chem, 2019
Jendroszek A, Madsen JB, Chana-Muñoz A, Dupont DM, Christensen A, Panitz F, Füchtbauer EM, Lovell SC, Jensen JK.   +8 more
europepmc   +1 more source

Effects of Progesterone and 17β-Estradiol under Presence or Absence of FBS on Plasminogen Activators Activity in Porcine Uterine Epithelial Cells. [PDF]

Dev Reprod, 2018
Hwangbo Y, Lee MR, Cheong HT, Yang BK, Park CK.   +4 more
europepmc   +1 more source