Results 101 to 110 of about 14,970 (304)

Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators

BMC Cancer, 2006
Background Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a two-step process, starting with the conversion of plasminogen to plasmin by ...
Maass Cathy N, Lamers-Elemans Iris L, Ruers Theo JM, de Groot-Besseling Renate RJ, de Waal Robert MW, Westphal Johan R   +5 more
doaj   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Enhanced Expression of Plasminogen Activators and Inhibitor in the Healing of Tympanic Membrane Perforation in Rats. [PDF]

J Assoc Res Otolaryngol, 2023
Makuszewska M, Cieślińska M, Winnicka MM, Skotnicka B, Niemczyk K, Bonda T.   +5 more
europepmc   +1 more source

Polarized secretion of plasminogen activators by epithelial cell monolayers.

, 1992
We have investigated the synthesis and the polarized secretion of plasminogen activators (PAs) in three epithelial cell lines (FRT, derived from rat thyroid; MDCK, from canine kidney, and CaCo-2, from human intestine) grown on filters, in bicameral ...
GENTILE R, ZURZOLO, CHIARA, GARBI, CORRADO, CANIPARI R, CAL G, ALOJ L, NITSCH, LUCIO, POLISTINA C   +7 more
core   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state

Reproductive Biology and Endocrinology, 2019
Background The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation.
Genia F. Burchall, Dodie S. Pouniotis, Helena J. Teede, Sanjeeva Ranasinha, Kirsty A. Walters, Terrence J. Piva   +5 more
doaj   +1 more source

Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes

, 1994
Recent findings have elucidated the mechanism for clearance from the extracellular space of the two types of plasminogen activators, urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA), and their type-1 inhibitor (PAI-
Kjøller, Lars, Lars Sottrup-Jensen, Peter A. Andreasen, Petersen, Claus Munch, Claus Munch Petersen, Søren K. Moestrup, Nykjær, Anders, Andreasen, Peter A., Moestrup, Søren K., Sottrup-Jensen, Lars, Lars Kjøller, Gliemann, Jørgen, Anders Nykjaer, Jørgen Gliemann   +13 more
core   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: Video-assisted therapeutic risk communication

Journal of the Formosan Medical Association, 2014
Explaining the risks and benefits of recombinant tissue-plasminogen activator (rtPA) to eligible patients with acute ischemic stroke (AIS) within a few minutes is important but difficult.
Cheng-Yang Hsieh, Wei-Fen Chen, Chih-Hung Chen, Chih-Yuan Wang, Chien-Jung Chen, Edward Chia-Cheng Lai, Tsang-Shan Chen   +6 more
doaj   +1 more source