Results 41 to 50 of about 13,552 (164)

Pro-fibrinolytic potential of the third larval stage of Ascaris suum as a possible mechanism facilitating its migration through the host tissues

Parasites & Vectors, 2020
Background Ascaris roundworms are the parasitic nematodes responsible for causing human and porcine ascariasis. Whereas A. lumbricoides is the most common soil-transmitted helminth infecting humans in the world, A.
Alicia Diosdado, Fernando Simón, Rodrigo Morchón, Javier González-Miguel   +3 more
doaj   +1 more source

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Clinical and Translational Medicine, 2018
Background Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking.
Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh, Steven Idell   +15 more
doaj   +1 more source

The role of the fibrinolytic system in female reproductive disorders and depression

Thrombosis Update, 2020
Tissue plasminogen activator (tPA) and urinary plasminogen activator (uPA or urokinase) have important functions in the extracellular matrix. In the reproductive system, for example, tPA and uPA mediate tissue remodeling required for ovulation ...
Silvia Hoirisch-Clapauch, Benjamin Brenner   +1 more
doaj   +1 more source

A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles

TH Open
Plasminogen activator inhibitor type 1 (PAI-1) is the key regulator of the fibrinolytic system, thereby acting as a potent mediator in thrombosis. Plasminogen activators such as PAI-1 mediate the conversion of the inactive zymogen plasminogen to plasmin,
Jacob Wortley, Justin Vu, Neha Soogoor, Mebeli Becerra, Mohanakrishnan Sathyamoorthy   +4 more
doaj   +1 more source

Contribution of macrophages to plasmin activity in ewe bulk milk

Italian Journal of Animal Science, 2010
A total of 225 bulk sheep milk samples were collected throughout lactation to assess the contribution of macrophages to the regulation of the plasmin/plasminogen system. Samples were analyzed for composition, milk renneting parameters, and for activities
M. Albenzio, A. Sevi, A. Marzano, R. Marino, L. Schena, M. Caroprese   +5 more
doaj   +1 more source

Thrombotic risk markers: tissue plasminogen activator/tissue plasminogen activator inhibitor-1 complex (Part 1)

Вестник анестезиологии и реаниматологии
The fibrinolysis system is one of the most important regulators of homeostasis and participates in maintaining stable blood flow. The key element of this system is the balance of plasminogen activators and inhibitors, which can be considered as markers ...
M. M. Tanashyan, E. V. Roitman, A. A. Raskurazhev, P. I. Kuznetsova, A. S. Mazur   +4 more
doaj   +1 more source

Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

The Ukrainian Biochemical Journal, 2018
The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-I), in patients with stage ...
O. I. Yusova, O. V. Savchuk, T. V. Grinenko, O. B. Kuchmenko, L. S. Mhitaryan, O. H. Kupchins’ka, I. N. Yevstratova, O. O. Matova, N. M. Vasilinchuk, T. F. Drobot’ko   +9 more
doaj   +1 more source

Enhanced Expression of Plasminogen Activators and Inhibitor in the Healing of Tympanic Membrane Perforation in Rats. [PDF]

J Assoc Res Otolaryngol, 2023
Makuszewska M, Cieślińska M, Winnicka MM, Skotnicka B, Niemczyk K, Bonda T.   +5 more
europepmc   +1 more source

Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators

BMC Cancer, 2006
Background Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a two-step process, starting with the conversion of plasminogen to plasmin by ...
Maass Cathy N, Lamers-Elemans Iris L, Ruers Theo JM, de Groot-Besseling Renate RJ, de Waal Robert MW, Westphal Johan R   +5 more
doaj   +1 more source

Plasminogen Activators in Neurovascular and Neurodegenerative Disorders. [PDF]

Int J Mol Sci, 2021
Yepes M, Woo Y, Martin-Jimenez C.
europepmc   +1 more source