Plasminogen Activators in Neurovascular and Neurodegenerative Disorders. [PDF]
Int J Mol Sci, 2021 The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells surrounded by a basement membrane, pericytes, astrocytes, microglia and neurons.
Yepes M, Woo Y, Martin-Jimenez C.
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Premature delivery impacts the concentration of plasminogen activators and a plasminogen activator inhibitor and the plasmin activity in human milk [PDF]
Frontiers in Pediatrics, 2022 Background and aimsPlasmin in human milk partially hydrolyzes milk proteins within the mammary gland and may enhance the hydrolysis of milk proteins within the infant’s stomach. This study examined the effects of extremely preterm (EP)-, very preterm (VP)
Veronique Demers-Mathieu +2 more
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Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation [PDF]
Molecules, 2019 In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase.
Yunn-Hwa Ma +4 more
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Causal association of plasminogen activators and their inhibitors with Alzheimer's disease: a Mendelian randomization study. [PDF]
Arch Med SciIntroduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Guo X +6 more
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Support vector machine (SVM) based multiclass prediction with basic statistical analysis of plasminogen activators. [PDF]
BMC Res Notes, 2014 Plasminogen (Pg), the precursor of the proteolytic and fibrinolytic enzyme of blood, is converted to the active enzyme plasmin (Pm) by different plasminogen activators (tissue plasminogen activators and urokinase), including the bacterial activators ...
Muthukrishnan S, Puri M, Lefevre C.
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Plasminogen activator inhibitors [PDF]
Blood, 1987 Chemicals/CAS: fibrin, 9001-31-4; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; Carrier Proteins; Glycoproteins; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators; Protease Inhibitors; protease ...
Sprengers, E.D., Kluft, C.
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Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1 [PDF]
Data in Brief, 2016 Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Lihu Gong +6 more
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Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
Ilaria De Simone +9 more
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Studies with plasminogen activators [PDF]
, 1965 In the past decade, stimulated by the availability of fibrinolytic agents suitable for use in man in the treatment of thrombo-embolic vascular occlusion, there has been a great increase in interest in the components and functions of the fibrinolytic ...
McNicol, George P
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Journal of Baghdad College of Dentistry, 2022 Background: Monocyte chemotactic protein-1 (MCP-1) is a chemokine expressed by inflammatory and endothelial cells. It has a crucial role in initiating, regulating, and mobilizing monocytes to active sites of periodontal inflammation.
Safa A Hamad , Maha S Mahmood
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