The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays. [PDF]
PLoS ONE, 2017 Due to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen ...
Marlien Pieters +3 more
doaj +2 more sources
Plasminogen Activator Inhibitor 1, Cell Senescence, and Aging-Related Diseases [PDF]
CellsCellular senescence, including replicative senescence (RS) and stress-induced premature senescence (SIPS), is a state of the permanent arrest of cell growth, which can occur in proliferative cells and post-mitotic cells.
Rui-Ming Liu, Mary F. Nakamya
doaj +2 more sources
Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
Ilaria De Simone +9 more
doaj +2 more sources
Radiology and Oncology, 2015 Background. Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients ...
Lampelj Maja +8 more
doaj +2 more sources
Impaired Fibrinolysis in the Pathogenesis of Dengue Hemorrhagic Fever [PDF]
, 2002 The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever.
ten Cate, H +8 more
core +2 more sources
Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]
, 2005 Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H +10 more
core +2 more sources
Association of fibrinogen and plasminogen activator inhibitor-1
Pakistan Journal of Pharmaceutical Sciences, 2022 As the state of hyperfibrinogenemia in diabetes patients occurs due to hyperglycemia which also activates the coagulative cascade ultimately stimulating hepatic fibrinogen synthesis and thus increases clotting factors and PAI-1 levels in the blood ...
with diabetes mellitus Iffat Ara Aziz +6 more
doaj +1 more source
Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]
, 2009 Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Wörnle, Markus +4 more
core +1 more source
Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]
, 2003 Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R. +19 more
core +2 more sources
Plasminogen Activator – Multifunctional Protein of Plague Pathogen
Проблемы особо опасных инфекций, 2016 Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure.
L. M. Kukleva, A. V. Boiko
doaj +1 more source