Results 21 to 30 of about 111,828 (202)
Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model. [PDF]
PLoS ONE, 2014 BACKGROUND: The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control.
Kristina Svennerholm +6 more
doaj +1 more source
Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]
, 2012 Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Alan Prem Kumar +14 more
core +14 more sources
Scientific Reports, 2021 Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients.
Yu Zuo +9 more
doaj +1 more source
Polymerization of Plasminogen Activator Inhibitor-1 [PDF]
Journal of Biological Chemistry, 2001 The activity of the serine proteinase inhibitor (serpin) plasminogen activator inhibitor-1 (PAI-1) is controlled by the intramolecular incorporation of the reactive loop into beta-sheet A with the generation of an inactive latent species. Other members of the serpin superfamily can be pathologically inactivated by intermolecular linkage between the ...
A, Zhou +5 more
openaire +2 more sources
PLoS ONE, 2017 Due to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen ...
Marlien Pieters +3 more
doaj +1 more source
Plasminogen Activator – Multifunctional Protein of Plague Pathogen
Проблемы особо опасных инфекций, 2016 Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure.
L. M. Kukleva, A. V. Boiko
doaj +1 more source
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome [PDF]
, 2018 We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS).
Avsic-Zupanc, Tatjana +8 more
core +2 more sources
Frontiers in Cellular and Infection Microbiology, 2023 Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and, as a result, aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage.
Justyna Rajewska-Tabor +5 more
doaj +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources
Tissue plasminogen activator and plasminogen activator inhibitor 1 contribute to sonic hedgehog-induced in vitro cerebral angiogenesis. [PDF]
PLoS ONE, 2012 The molecular mechanisms underlying cerebral angiogenesis have not been fully investigated. Using primary mouse brain endothelial cells (MBECs) and a capillary-like tube formation assay, we investigated whether the sonic hedgehog (Shh) signaling pathway ...
Hua Teng +6 more
doaj +1 more source