Results 31 to 40 of about 68,036 (296)

Plasminogen Activator – Multifunctional Protein of Plague Pathogen

Проблемы особо опасных инфекций, 2016
Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure.
L. M. Kukleva, A. V. Boiko
doaj   +1 more source

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Mairuhu, A. T. A., Hack, C. E., Leyte, A, Osterhaus, A.D.M.E. (Albert), Koraka, P. (Penelope), Brandjes, D.P.M. (Dees), Mairuhu, A.T., ten Cate H, Brandjes, D.P., SMH Faradz, Faradz, S.M.H., van Gorp, E., Hack, C. Erik, Setiati, T., Brandjes DPM, Mairuhu, ATA, Osterhaus ADME, Setiati, T. E., Reitsma, PH, Osterhaus, A.D.M.E., Faradz, SMH, Faradz SMH, Gorp, E. van, Brandjes, D. P. M., van Gorp, E. C. M., Faradz, Sultana M.H., Setiati, T.E. (Tatty), Brandjes, D.P.M., Osterhaus, A.D., Setiati, Tatty E., van Gorp, E.C.M., Cate, H. (Hugo) ten, Koraka, P., Reitsma PH, van Gorp, Eric, Mairuhu, A.T.A., Mairuhu ATA, Reitsma, P., ECM van Gorp, Koraka, Penelopie, Reitsma, P.H., A Leyte, Setiati, TE, van Gorp, Eric C. M., Setiati TE, Osterhaus, Ab, Koraka, P, Leyte A, H ten Cate, ADME Osterhaus, Osterhaus, A. D. M. E., Hack CE, PH Reitsma, Setiati, T.E., Hack, C.E., Osterhaus, ADME, Faradz, S. M. H., CE Hack, Reitsma, P. H., van Gorp ECM, ATA Mairuhu, Osterhaus, A., TE Setiati, Koraka P, Leyte, A. (Anja), P Koraka, Mairuhu, A., Faradz, S.M.H. (Sultana), Gorp, E.C.M. (Eric) van, Hack, CE, DPM Brandjes, Hack, C., Faradz, S., Cate, H. Ten, Hack, C.E. (Erik), ten Cate, H., Leyte, A.   +78 more
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Expression of plasminogen activators and plasminogen activator inhibitor 1 in dedifferentiated chondrosarcoma [PDF]

Cancer, 1997
The plasminogen activator system plays an important role in different malignant tumors. These enzymes participate in the destruction of intercellular matrices and basement membranes and/or can modulate the growth potency of tumor cells and may even promote metastases.
C, Häckel, B, Czerniak, A G, Ayala, K, Radig, A, Roessner   +4 more
openaire   +2 more sources

JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells

Journal of Biomedical Science, 2011
Background Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular
Chen Wei-Kung, Chen Li-Mien, Kuo Wei-Wen, Lin Yueh-Min, Hu Wei-Syun, Hsu Hsi-Hsien, Hwang Jin-Ming, Tsai Fuu-Jen, Liu Chung-Jung, Huang Chih-Yang   +9 more
doaj   +1 more source

Impaired Fibrinolysis in the Pathogenesis of Dengue Hemorrhagic Fever [PDF]

, 2002
The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever.
Eric C.M. van Gorp, ten Cate, H, Brandjes, DPM, Wil M.V. Dolmans, van der Meer, Jos W. M., Mairuhu, Albert T. A., Cate Ht, Hugo ten, Mairuhu, A.T., Brandjes, D.P., Cate, H.H., Setiati, T.E., Dolmans, W.M.V., Jos W.M. van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Mairuhu, ATA, Cate, H. ten, C. Erik Hack, Suharti, C., Catharina Suharti, Gorp, E. van, Brandjes, D.P.M., Albert T.A. Mairuhu, Dolmans, Wil M. V., Meer, J.W.M. van der, Setiati, Tatty E., Mairuhu, A.T.A., Tatty E. Setiati, Suharti, Catharina, Dees P.M. Brandjes, van Gorp, Eric C. M., Gorp, E.C.M. van, Brandjes, Dees P. M.   +33 more
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Protective role of N-acetylcysteine and Sulodexide on endothelial cells exposed on patients’ serum after SARS-CoV-2 infection

Frontiers in Cellular and Infection Microbiology, 2023
Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and, as a result, aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage.
Justyna Rajewska-Tabor, Patrycja Sosińska-Zawierucha, Malgorzata Pyda, Maciej Lesiak, Andrzej Bręborowicz, Andrzej Bręborowicz   +5 more
doaj   +1 more source

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Kellermann, Josef, Wilhelm, Olaf G., Riemer, Christoph, Bürgle, Markus, Schroeck, Florian, Schmitt, Manfred, Kessler, Horst, Degitz, Klaus, Arroyo de Prada, Nuria, Schmiedeberg, Niko, Magdolen, Viktor   +10 more
core   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Tissue plasminogen activator and plasminogen activator inhibitor 1 contribute to sonic hedgehog-induced in vitro cerebral angiogenesis. [PDF]

PLoS ONE, 2012
The molecular mechanisms underlying cerebral angiogenesis have not been fully investigated. Using primary mouse brain endothelial cells (MBECs) and a capillary-like tube formation assay, we investigated whether the sonic hedgehog (Shh) signaling pathway ...
Hua Teng, Michael Chopp, Ann Hozeska-Solgot, Lihong Shen, Mei Lu, Clark Tang, Zheng Gang Zhang   +6 more
doaj   +1 more source

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis [PDF]

, 2010
Background: Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulfilled by membrane-associated ...
Olivier Gires, Muehlenweg Bernd, Pamela Zengel, Muehlenweg, Bernd, Gires, Olivier, Ramp, D., Gires, O., Alexander Berghaus, Gires Olivier, Mack, Brigitte, Zengel, Pamela, Zahler, Stefan, Muehlenweg, B., Diana Ramp, Stefan Zahler, Mack, B., Bernd Muehlenweg, Zahler, S., Berghaus Alexander, Mack Brigitte, Zengel, P., Suna Schmitz, Berghaus, Alexander, Schmitz, Suna, Schmitz, S., Ramp, Diana, Schmitz Suna, Zahler Stefan, Zengel Pamela, Brigitte Mack, Ramp Diana, Berghaus, A.   +31 more
core   +1 more source