Results 231 to 240 of about 155,151 (257)

Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe?4S] protein

JBIC Journal of Biological Inorganic Chemistry, 2005
The mevalonate-independent methylerythritol phosphate pathway is widespread in bacteria. It is also present in the chloroplasts of all phototrophic organisms. Whereas the first steps, are rather well known, GcpE and LytB, the enzymes catalyzing the last two steps have been much less investigated.
Seemann, M., Wegner, P., Shunemann, V., Bui B. Tse, Sum, Wolff, M., Marquet, A., X. Trautwein, A., Rohmer, M.   +7 more
openaire   +3 more sources

(3R,4S)-3,4,5-Trihydroxy-4-methylpentylphosphonic acid, an isosteric phosphonate analogue of 2-C-methyl-d-erythritol 4-phosphate, a key intermediate in the new pathway for isoprenoid biosynthesis

Tetrahedron Letters, 2004
Abstract 2- C -Methyl- d -erythritol 4-phosphate (MEP) is the first intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis presenting the branched C 5 isoprene skeleton. Enantiopure (3 R ,4 S )-3,4,5-trihydroxy-4-methylpentylphosphonic acid (MEP N ), an isosteric phosphonate analogue of MEP was synthesized from 1,2- O ...
Guillaume Hirsch, Catherine Grosdemange-Billiard, Denis Tritsch, Michel Rohmer   +3 more
openaire   +1 more source

Isoprenoid biosynthesis via the MEP pathway. Synthesis of (3R,4S)-3,4-dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-d-xylulose 5-phosphate, the substrate of the 1-deoxy-d-xylulose 5-phosphate reducto-isomerase

Organic & Biomolecular Chemistry, 2003
(3,4)-3,4-Dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-D-xylulose 5-phosphate (DXP), was obtained in enantiomerically pure form from (+)-2,3--benzylidene--threitol by a seven-step sequence. This phosphonate did not affect the growth of.
Odile, Meyer, Catherine, Grosdemange-Billiard, Denis, Tritsch, Michel, Rohmer   +3 more
openaire   +2 more sources

Characterization of ferredoxins involved in electron transfer pathways for nitrogen fixation implicates differences in electronic structure in tuning 2[4Fe 4S] Fd activity

Journal of Inorganic Biochemistry
Ferredoxins (Fds) are small proteins which shuttle electrons to pathways like biological nitrogen fixation. Physical properties tune the reactivity of Fds with different pathways, but knowledge on how these properties can be manipulated to engineer new electron transfer pathways is lacking. Recently, we showed that an evolved strain of Rhodopseudomonas
Nathan M, Lewis, Effie C, Kisgeropoulos, Carolyn E, Lubner, Kathryn R, Fixen   +3 more
openaire   +2 more sources

QM/MM study of the [4Fe-4S]-dependent (R)-2-hydroxyisocaproyl-CoA dehydratase: Dehydration via a redox pathway with an α-carbonyl radical intermediate

Journal of Catalysis, 2023
Wen-Jie Wei, Rong-Zhen Liao
openaire   +1 more source

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Nature Reviews Drug Discovery, 2020
Anwesha Dey, Xaralabos Varelas, Kun-Liang Guan   +2 more
exaly  

Targeting Apoptosis Pathways in Cancer Therapy

Ca-A Cancer Journal for Clinicians, 2005
Thomas E Witzig
exaly  

Targeting the phosphoinositide 3-kinase pathway in cancer

Nature Reviews Drug Discovery, 2009
Pixu Liu, Hailing Cheng, Thomas M Roberts   +2 more
exaly  

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Nature Reviews Drug Discovery, 2013
Randy Johnson, Georg Halder
exaly  

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Nature Reviews Drug Discovery, 2005
Bryan T Hennessy, Prahlad T Ram, Gordon B Mills   +2 more
exaly