Results 71 to 80 of about 12,456,978 (213)

Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients

مجلة بغداد للعلوم, 2010
Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy.
Baghdad Science Journal
doaj   +1 more source

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

Organ Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Mediators of Inflammation, 2014
Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is
Cátia Vieira, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Isabel Silva, Ana Sofia Dias, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá   +7 more
doaj   +1 more source

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine*

Journal of Biological Chemistry, 2013
Background: Newborns have elevated plasma adenosine levels, which may influence their immunological function. Results: Compared with adults, newborns have elevated plasma 5′-NT and alkaline phosphatase activities and lower adenosine deaminase activity ...
M. Pettengill, S. Robson, Megan Tresenriter, J. Millán, A. Usheva, T. Bingham, M. Belderbos, Ilana Bergelson, S. Burl, B. Kampmann, Laura Gelinas, T. Kollmann, L. Bont, O. Levy   +13 more
semanticscholar   +1 more source

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits substantial pharmacokinetics (PK) variability, contributing to suboptimal outcomes.
Mourad Mseddi, Christa Nath, Khalil Ben Hassine, Vid Mlakar, Yvonne Gloor, Fanny Gonzales, Chakradhara Rao S. Uppugunduri, Youssef Daali, Steven Keogh, Marc Ansari   +9 more
wiley   +1 more source

Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase

PLoS ONE, 2012
Macrophages are key elements in the inflammatory process, whereas depending on the micro-environmental stimulation they exhibit a pro-inflammatory (classical/M1) or an anti-inflammatory/reparatory (alternative/M2) phenotype.
R. Zanin, E. Braganhol, L. Bergamin, L. F. Campesato, Alfeu Zanotto Filho, J. Moreira, F. Morrone, J. Sévigny, M. Schetinger, Ângela Terezinha de Souza Wyse, A. Battastini   +10 more
semanticscholar   +1 more source

Tissue-Resident Ecto-5′ Nucleotidase (CD73) Regulates Leukocyte Trafficking in the Ischemic Brain

Journal of Immunology, 2012
Ectoenzymes expressed on the surface of vascular cells and leukocytes modulate the ambient nucleotide milieu. CD73 is an ecto-5′ nucleotidase that catalyzes the terminal phosphohydrolysis of AMP and resides in the brain on glial cells, cells of the ...
D. Petrović-Djergović, Matthew C. Hyman, Jessica J. Ray, Diane Bouis, Scott H. Visovatti, Takanori Hayasaki, D. Pinsky   +6 more
semanticscholar   +1 more source

The Enzyme Of 5'-Nucleotidase and Clinical Significance

Eurasian Journal of Medicine, 2019
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Vediye Gürsel, Necati Kaya
doaj  

The 5'-nucleotidase S5nA is dispensable for evasion of phagocytosis and biofilm formation in Streptococcus pyogenes.

PLoS ONE, 2019
5'-nucleotidases are widespread among all domains of life. The enzymes hydrolyze phosphate residues from nucleotides and nucleotide derivatives. In some pathobiontic bacteria, 5'-nucleotidases contribute to immune evasion by dephosphorylating adenosine ...
Marcel-Lino Dangel, Johann-Christoph Dettmann, Steffi Haßelbarth, Martin Krogull, Miriam Schakat, Bernd Kreikemeyer, Tomas Fiedler   +6 more
doaj   +1 more source

Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells.

Acta Biochimica Polonica, 2012
Ecto-5'-nucleotidase (eN, CD73) mediates extracellular adenosine production from 5'-AMP. Non-enzymatic functions of eN have also been reported. The aim of the study was to investigate the role of ecto-5'-nucleotidase in aggressive melanoma behaviour ...
R. Sądej, A. Składanowski
semanticscholar   +1 more source