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5-aminolevulinic acid-induced fluorescence cystoscopy for photodynamic diagnosis of bladder tumors: Oral versus intravesical administration. [PDF]
Urol AnnAlnaieb Z, Osman E, Medani S.
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5-Aminolevulinic acid synthase: mechanism, mutations and medicine
Biochimica Et Biophysica Acta - Proteins and Proteomics, 2003 5-Aminolevulinic acid synthase (ALAS), the first enzyme of the heme biosynthesis pathway, catalyses the pyridoxal 5'-phosphate-dependent condensation between glycine and succinyl-CoA to yield 5-aminolevulinic acid (5-amino-4-oxopentanoate).
Ipsita Roy +2 more
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The stability of 5-aminolevulinic acid in solution
Journal of Photochemistry and Photobiology B: Biology, 20025-Aminolevulinic acid (ALA) is being assessed for photodynamic therapy of cancer and other diseases worldwide. However, its stability properties in solution are not well understood yet. The breakdown of ALA in pH-buffered solutions was examined in this work.
Øystein Bech, Gadmar +4 more
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Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid [PDF]
American Journal of Obstetrics and Gynecology, 1996 ObjectiveOur purpose was to determine the feasibility of selective photosensitization of vulvar condylomas by use of tropical application of 5-aminolevulinic acid.Study designIn vivo fluorescence was assessed and biopsy specimens of condylomas were taken
Michael W. Berns +2 more
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Selective photosensitizer localization in the human endometrium after intrauterine application of 5-aminolevulinic acid [PDF]
American Journal of Obstetrics and Gynecology, 1996 OBJECTIVE:Our purpose was twofold: to determine the distribution of the endogenous photosensitizer protoporphyrin IX in the uterus and to ascertain the time interval leading to maximal endometrial fluorescence after intrauterine instillation of 5 ...
Yona Tadir, Mathias K Fehr, Pius Wyss
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5-Aminolevulinic Acid Imaging of Malignant Glioma
Surgical Oncology Clinics of North America, 2022High-grade glioma is the most common malignant primary brain tumor in adults. Glioma infiltration renders it difficult to treat and likely to recur. Increasing the extent of resection has been associated with improving progression-free survival and overall survival by several months. The introduction of 5-aminolevulinic acid (5-ALA) fluorescence-guided
Guan, Li +6 more
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Photochemistry and Photobiology, 2000
5-aminolevulinic acid (5-ALA) and its ester derivatives are used in photodynamic therapy as precursors for the formation of photosensitizers. This study relates to the mechanisms by which 5-ALA is transported into cells. The transport of 5-ALA has been studied in a human adenocarcinoma cell line (WiDr) by means of [14C]-labeled 5-ALA.
E, Rud, O, Gederaas, A, Høgset, K, Berg
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5-aminolevulinic acid (5-ALA) and its ester derivatives are used in photodynamic therapy as precursors for the formation of photosensitizers. This study relates to the mechanisms by which 5-ALA is transported into cells. The transport of 5-ALA has been studied in a human adenocarcinoma cell line (WiDr) by means of [14C]-labeled 5-ALA.
E, Rud, O, Gederaas, A, Høgset, K, Berg
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Hemodynamic effects of 5-aminolevulinic acid in humans
Journal of Photochemistry and Photobiology B: Biology, 1998Endogenous protoporphyrin IX (PpIX), which results from the oral administration of 5-aminolevulinic acid (ALA), is being investigated for its efficacy as a photosensitizing agent for photodynamic therapy (PDT). Clinical use of ALA has been associated with only mild gastrointestinal side effects.
M A, Herman +3 more
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Oxidative damage to ferritin by 5-aminolevulinic acid
Archives of Biochemistry and Biophysics, 20035-Aminolevulinic acid (ALA), a heme precursor overproduced in various porphyric disorders, has been implicated in iron-mediated oxidative damage to biomolecules and cell structures. From previous observations of ferritin iron release by ALA, we investigated the ability of ALA to cause oxidative damage to ferritin apoprotein.
Maria E.M Rocha +9 more
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Fluorometric measurement of 5-aminolevulinic acid in serum
Clinica Chimica Acta, 2004Measurement of 5-aminolevulinic acid (ALA) in serum is potentially useful in acute porphyrias, lead poisoning and hereditary tyrosinemia. Because levels of ALA in serum are about 100 times less than in urine, a highly sensitive method is required. We describe a simple and sensitive fluorometric method that does not require HPLC.ALA is separated from ...
Chul, Lee +3 more
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