Results 171 to 180 of about 13,836,709 (221)

Biosynthesis of 5-Aminolevulinic Acid

2009
5-Aminolevulinic acid (ALA) is the general precursor of all known tetrapyrroles. Currently, two different biosynthetic routes for ALA formation are known. Humans, animals, fungi and the α-group of the proteobacteria employ the one-step-condensation of succinyl-coenzyme A and glycine catalyzed by pyridoxal 5′-phosphate-dependent ALA synthase. In plants,
Dieter Jahn, Dirk W. Heinz
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Effects of 5-aminolevulinic acid on the glutamatergic neurotransmission

Neurochemistry International, 2003
The haem precursor 5-aminolevulinic acid (ALA) has been proposed to be involved in the neurological dysfunctions presented by patients with acute porphyrias. The effects of ALA on the [3H]glutamate and [3H]MK-801 (dizocilpine) binding to rat cortical membranes and on [3H]glutamate uptake by rat astrocyte cultures were evaluated in the present study in ...
Tatiana, Emanuelli, Fernanda W, Pagel, Lisiane O, Porciúncula, Diogo O, Souza   +3 more
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Photosensitization of the endometrium with topical 5-aminolevulinic acid

American Journal of Obstetrics and Gynecology, 1995
Photosensitization of the endometrium was attempted in vitro and in vivo by intrauterine administration of 5-aminolevulinic acid, which is converted to the photosensitizer protoporphyrin IX. Protoporphyrin IX was found in both functional and basal layers of the endometrial glands at concentrations nine and 10 times higher than myometrium in in vitro ...
M J, Gannon, N, Johnson, D J, Roberts, J A, Holroyd, D I, Vernon, S B, Brown, R J, Lilford   +6 more
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5-Aminolevulinic Acid-Hyaluronic Acid Complexes Enhance Skin Retention of 5-Aminolevulinic Acid and Therapeutic Efficacy in the Treatment of Hypertrophic Scar

AAPS PharmSciTech, 2022
Hypertrophic scar is a serious skin disorder, which reduces the patient's quality of life. 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy has been used to treat patients with hypertrophic scar. However, the poor skin retention of 5-ALA limited the therapeutic effect.
Liya, Yang, Huihui, Deng, Yiman, Chen, Yuling, Chen, Ling, Guo, Min, Feng   +5 more
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Microbial production and applications of 5-aminolevulinic acid

Applied Microbiology and Biotechnology, 2014
5-Aminolevulinic acid (ALA), an important intermediate in tetrapyrrole biosynthesis in organisms, has been widely applied in many fields, such as medicine, agriculture, and the food industry, due to its biochemical characteristics. Research efforts supporting the microbial production of ALA have received increasing interest due to its dominant ...
Shuli, Liu, Guangming, Zhang, Xiangkun, Li, Jie, Zhang   +3 more
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Degradation mechanism and stability of 5‐aminolevulinic acid

Journal of Pharmaceutical Sciences, 2000
The physiological substance and precursor of the heme synthesis 5-aminolevulinic acid (ALA) is a promising prodrug for photodiagnosis and photodynamic therapy of epithelial tumors, particularly in urological and gynecological tissues. For the clinical use of this substance, a chemically stable and sterile drug formulation is required.
Bunke A, Zerbe O, Schmid H, Burmeister G, Merkle HP, Gander B   +5 more
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Pleiotropic effects of 5-aminolevulinic acid in mouse brain

Biochemistry and Cell Biology, 2016
5-Aminolevulinic acid (ALA) seems to be responsible for the neuropsychiatric manifestations of acute intermittent porphyria (AIP). Our aim was to study the effect of ALA on the different metabolic pathways in the mouse brain to enhance our knowledge about the action of this heme precursor on the central nervous system. Heme metabolism, the cholinergic
Lavandera, Jimena Veronica, Rodriguez, Jorge, Ruspini, Silvina Fernanda, Meissl, Roberto Jose, Zuccoli, Johanna Romina, Martinez, Maria del Carmen, Gerez, Esther Noemi, Batlle, Alcira María del C., Buzaleh, Ana Maria   +8 more
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Production of 5-aminolevulinic acid by methanogens

Journal of Fermentation and Bioengineering, 1989
Abstract The possibility of 5-aminolevulinic acid (ALA) accumulation in a culture medium was studied using Methanosarcina barkeri growing on a methanol minimal medium. To effect the accumulation of ALA in the culture medium, some ALA analogues were tested as inhibitors of ALA dehydratase.
Dong Lin, Naomichi Nishio, Shiro Nagai
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Uroporphyria produced in mice by iron and 5-aminolevulinic acid

Biochemical Pharmacology, 1991
Porphyria cutanea tarda and the analogous hepatic uroporphyria produced in rodents by aromatic hydrocarbons result from inactivation of hepatic uroporphyrinogen decarboxylase (UROD). Inactivation appears to be iron-dependent and may require induction of cytochromes of the P450IA subfamily.
S, Deam, G H, Elder
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Two biosynthetic pathways to 5-aminolevulinic acid in algae

International Journal of Biochemistry, 1980
Abstract 1. 1. In the X-ray induced mutant C-2A' of the green alga Scenedesmus obliquus, the formation of 5-aminolevulinic acid (LALA) is light dependent. ALA so formed arises by the classical ALA synthetase pathway involving glycine and succinate as substrates and also by the C-5 pathway using the intact 5-carbon skeleton of glutamate or 2-keto ...
O, Klein, D, Dörnemann, H, Senger
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