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Disposition of 5-Aminosalicylic Acid by 5-Aminosalicylic Acid-Delivering Compounds
Scandinavian Journal of Gastroenterology, 1988The disposition of 5-aminosalicylic acid (5-ASA) from 5-ASA-delivering drugs was studied in eight healthy volunteers. Time-related urinary excretion and faecal excretion of 5-ASA and acetyl-5-ASA were measured after a single oral dose of the azo compounds sulphasalazine and olsalazine, of the slow-release compounds Pentasa, Asacol, and Salofalk, and of
M C, Rijk +2 more
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New metabolites of the drug 5-aminosalicylic acid. II. N-Formyl-5-aminosalicylic acid
Xenobiotica, 19911. A new metabolite of the drug 5-aminosalicylic acid (5-ASA) has been found in urine from pigs and in plasma of humans. The metabolite has been isolated from pig urine using an XAD-2 column and purified using preparative h.p.l.c. 2. The metabolite has been identified as N-formyl-5-ASA (5-formamidosalicylic acid) using 1H- and 13C-n.m.r.
J, Tjørnelund, S H, Hansen, C, Cornett
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Stability of 5-aminosalicylic acid suspension
American Journal of Health-System Pharmacy, 1986The stability of 5-aminosalicylic acid in a suspension prepared extemporaneously for administration by enema was studied. The suspension was prepared (tragacanth was the suspending agent) and then placed in 3-ounce amber glass prescription bottles; five bottles were stored at room temperature and five were refrigerated for 90 days.
H A, Montgomery +4 more
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Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid
Journal of Chromatography B: Biomedical Sciences and Applications, 19945-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic efficacy. In this study oxidation products of aminosalicylates with hydroxyl radicals were produced.
C, Fischer, U, Klotz
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In vivo radioprotection by 5-aminosalicylic acid
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2008The radioprotective effect of 5-aminosalicylic acid (5ASA) was investigated in mouse bone marrow. The present study was aimed at investigating the radioprotective effect of pre-irradiation treatment with 5ASA against a range of whole-body lethal (8-11 Gy) and sublethal (1-4 Gy) doses of gamma-radiation (RT) in adult Swiss albino mice.
S K, Mantena +5 more
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Oral desensitization to 5-aminosalicylic acid medications
Annals of Allergy, Asthma & Immunology, 1999Although hypersensitive subjects have been desensitized to oral sulfasalazine, the feasibility of oral desensitization to the drug's active moiety, 5-aminosalicylic acid has been questioned and never been reported.We devised a 5-aminosalicylic acid desensitization protocol and administered the drug to two hypersensitive subjects on three occasions.Both
R C, Stelzle, E N, Squire
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Pharmacology and pharmacokinetics of 5-aminosalicylic acid
Digestive Diseases and Sciences, 1987There is accumulating clinical evidence that 5-aminosalicylic acid (5-ASA), a primary metabolite of sulfasalazine (SAS), represents the therapeutic active moiety of the azo-compound SAS in the treatment of chronic inflammatory bowel disease (IBD). Since it is presumed that 5-ASA acts from the lumen of the intestine, it is important to know how much 5 ...
U, Klotz, K E, Maier
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Nihon rinsho. Japanese journal of clinical medicine, 2019
Despite the emergence of new biological therapies that aim for mucosal healing as a new therapeutic target, the importance of 5-ASA formulations in the standard treatment for inflammatory bowel diseases, particularly ulcerative colitis, remains unchanged.
Tomoya, Iida +2 more
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Despite the emergence of new biological therapies that aim for mucosal healing as a new therapeutic target, the importance of 5-ASA formulations in the standard treatment for inflammatory bowel diseases, particularly ulcerative colitis, remains unchanged.
Tomoya, Iida +2 more
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Acta Obstetricia et Gynecologica Scandinavica, 1994
To determine the concentration of 5-aminosalicylic acid (5-ASA) and the metabolite N-acetyl-5-aminosalicylic acid (Ac-5-ASA) in the maternal and fetal plasma at delivery and in the maternal milk post partum.Pregnant and lactating women with chronic inflammatory bowel disease, treated with different pure 5-ASA preparations participated in the study.
L A, Christensen +2 more
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To determine the concentration of 5-aminosalicylic acid (5-ASA) and the metabolite N-acetyl-5-aminosalicylic acid (Ac-5-ASA) in the maternal and fetal plasma at delivery and in the maternal milk post partum.Pregnant and lactating women with chronic inflammatory bowel disease, treated with different pure 5-ASA preparations participated in the study.
L A, Christensen +2 more
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