Results 181 to 190 of about 25,240 (222)

Substituted hexahydrobenzodipyrans as 5-HT2A/2C receptor probes

Bioorganic & Medicinal Chemistry, 2002
A pair of substituted hexahydrobenzodipyrans was designed as molecular probes for determining the steric restrictions of the agonist binding site of serotonin 5-HT2A and 5-HT2C receptors. The rationale for the design of these receptor ligands, their chemical synthesis, rat behavioral pharmacology in the two-lever drug discrimination assay using LSD ...
Michael S, Whiteside, Deborah, Kurrasch-Orbaugh, Danuta, Marona-Lewicka, David E, Nichols, Aaron, Monte   +4 more
openaire   +2 more sources

5-HT2A receptor gene polymorphism and eating disorders

Neuroscience Letters, 2002
Recent studies have reported a genetic association between the -1438 G/A polymorphism within the promoter region of the 5-HT(2A) receptor gene and eating disorders (ED), with conflicting results. To clarify the role of the -1438 G/A polymorphism in different ED categories we have analyzed the genotype and allele frequency distribution in 54 Italian ...
RICCA, VALDO, NACMIAS, BENEDETTA, Cellini E, Di Bernardo M, ROTELLA, CARLO MARIA, SORBI, SANDRO   +5 more
openaire   +3 more sources

Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice

Biochemical and Biophysical Research Communications, 2006
Serotonin (5-hydroxytryptamine; 5-HT) 2A receptors contribute to the effects of 5-HT on platelet aggregation and vascular smooth muscle cell proliferation, and are reportedly involved in decreases in plasma levels of adiponectin, an adipokine, in diabetic subjects.
Katsunori, Nonogaki, Kana, Nozue, Yoshitomo, Oka   +2 more
openaire   +2 more sources

5-HT2A Receptor Heterodimerization

2018
Interaction of serotonin 5-HT2A receptor with other G protein-coupled receptors (GPCRs) have been shown at the behavioral and/or electrophysiological level. In the present chapter evidence for direct physical interactions of this receptor with various GPCRs have been described.
Sylwia Łukasiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska   +2 more
openaire   +1 more source

5-HT2A Receptors and Pain

2018
Serotonin (5-hydroxytryptamine, 5-HT) is a key modulator of spinal nociceptive transmission. Among 5-HT receptors, the 5-HT2A subtype plays a critical role in the modulation of nociceptive information. Both pro- and antinociceptive effects of 5-HT2A receptor activation have been reported but converging evidence indicates an excitatory role for ...
Christine Courteix, Amandine Dupuis, Pierre-Yves Martin, Benoit Sion   +3 more
openaire   +1 more source

5-HT2A Receptors in Eating Disorders

2018
Eating disorders consist in anorexia nervosa (lack of energy intake and/or excess of caloric consumption) bulimia nervosa (episodes of binge eating associated with compensatory behaviors, such as self-induced vomiting, misuse of laxative, diuretics, fasting or excessive exercise) and binge eating disorder (recurrent episodes of binge eating without ...
Philip Gorwood, Laurence Lanfumey, Odile Viltart, Nicolas Ramoz   +3 more
openaire   +1 more source

5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia

The Lancet, 1997
Vol 349 • June 21, 1997 1815 activates Ca-sensitive ion channels leading to saliva formation. Myoepithelial cells are believed to play a central part in the reflex salivary flow by concentration, which may stimulate the release of acinar cell contents and exert some counterpressure during stimulated salivary flow.
A P, Kouzmenko, W L, Hayes, A M, Pereira, B, Dean, P W, Burnet, P J, Harrison   +5 more
openaire   +2 more sources

The role of 5-HT2A receptors in antipsychotic activity

Life Sciences, 1995
The correlation between the clinical activity of antipsychotic agents and their affinity for the D2 dopamine receptor has been the mainstay of the hypothesis that schizophrenia is due to excessive dopaminergic function. More recently, the unique clinical profile of the atypical antipsychotic clozapine has been proposed to involve actions on additional ...
C J, Schmidt, S M, Sorensen, J H, Kehne, A A, Carr, M G, Palfreyman   +4 more
openaire   +2 more sources

Cocaine Potentiates Multiple 5-HT2A Receptor Signaling Pathways and Is Associated with Decreased Phosphorylation of 5-HT2A Receptors In Vivo

Journal of Molecular Neuroscience, 2014
Cocaine addiction is a chronic relapsing disorder in which the underlying mechanisms are not well understood. Here, we used Sprague-Dawley rats injected with either saline (1 ml/kg) or cocaine (15 mg/kg) for 7 days (b.i.d, i.p) to study the effect of cocaine on several components of 5-HT2A receptor signaling in prefrontal cortex (PFCx).
Jade M, Franklin, Gonzalo A, Carrasco
openaire   +2 more sources

5-HT2A Receptors in the Basal Ganglia

2018
The serotonin2A (5-HT2A) receptor is present in the basal ganglia (BG), a group of subcortical structures involved in the control of motor behaviours. It is one of the numerous serotonin (5-HT) G-protein coupled receptors responding to the release of 5-HT from neurons of the dorsal raphe nucleus. The interest brought to the function of 5-HT2A receptors
Cristina Miguelez, Teresa Morera-Herreras, Philippe De Deurwaerdère   +2 more
openaire   +1 more source