Results 151 to 160 of about 125,938 (267)

Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands. [PDF]

J Cereb Blood Flow Metab, 2017
Ganz M, Feng L, Hansen HD, Beliveau V, Svarer C, Knudsen GM, Greve DN.   +6 more
europepmc   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model. [PDF]

Sci Rep
Redenšek Trampuž S, van Riet S, Nordling Å, Ingelman-Sundberg M.   +3 more
europepmc   +1 more source

Effect of Selective 5-HT6R Agonist on Expression of 5-HT Receptor and Neurotransmitter in Vascular Dementia Rats. [PDF]

Med Sci Monit, 2017
Yu H, Chen T, Zhou L, Tang J.
europepmc   +1 more source

Increase of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems via allosteric receptor-receptor interaction [PDF]

, 2015
Dasiel O. Borroto‐Escuela, Manuel Narváez, Antonio Jimenez‐Beristain, Julia Oflijan, Luca Pinton, Michael Di Palma, Alexander O. Tarakanov, Giuseppa Mudò, Luigi F. Agnati, Natale Belluardo, Kjell Fuxé   +10 more
openalex   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT₃ receptors in the proximal colon

Preedajit Wongkrasant, Laurie E. Wallace, Wallace K. MacNaughton, Keith A. Sharkey   +3 more
openalex   +1 more source

Correction to: MicroRNA-34 Contributes to the Stress-related Behavior and Affects 5-HT Prefrontal/GABA Amygdalar System through Regulation of Corticotropin-releasing Factor Receptor 1 [PDF]

, 2019
Diego Andolina, Matteo Di Segni, Alessandra Accoto, Luisa Lo Iacono, Antonella Borreca, Donald Ielpo, Nicola Berretta, Emerald Perlas, Stefano Puglisi‐Allegra, Rossella Ventura   +9 more
openalex   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Agonist interactions with 5‐HT₃ receptor recognition sites in the rat entorhinal cortex labelled by structurally diverse radioligands [PDF]

, 1992
Janine M. Barnes, Nicholas M. Barnes, B. Costall, S.M. Jagger, R.J. Naylor, David W. Robertson, S.Y. Roe   +6 more
openalex   +1 more source