Results 241 to 250 of about 1,554,548 (330)

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

510 Kirkendall Effect in Diffusion Bonding and Laser Roll Bonding of A5052 aluminium alloy and SPCC steel

, 2003
Manoj Rathod, Muneharu Kutsuna
openalex   +2 more sources

Shielding Si Armed with CoSi2 Nanoplates and Dual‐Carbon Shells: 3D Porous Microspheres as High‐Performance Anodes for Li‐Ion Batteries

Advanced Science, EarlyView.
The lithium‐ion battery anode is designed utilizing 3D porous microspheres comprising Si armed with CoSi2 multi‐cores encapsulated within dual protective shells of metallic‐Co embedded nitrogen‐doped graphitic carbon (NGC) and polydopamine‐derived carbon (PDA‐C).
Jae Seob Lee, Hyun Seon Ahn, Jung Yeon Kim, Rakesh Saroha, Beom Su Jo, Ji Hun Baek, Yun Chan Kang, Gi Dae Park, Dae Soo Jung, Dong‐Won Kang, Chungyeon Cho, Jung Sang Cho   +11 more
wiley   +1 more source

SCORCH2: A Generalized Heterogeneous Consensus Model for High‐Enrichment Interaction‐Based Virtual Screening

Advanced Science, EarlyView.
Researchers developed SCORCH2, an advanced machine‐learning scoring function for virtual screening that combines two complementary XGBoost models to re‐evaluate protein‐ligand binding plausibility. The method demonstrates superior performance on standard benchmarks, shows excellent generalization to previously unseen protein targets, and provides ...
Lin Chen, Vincent Blay, Pedro J. Ballester, Douglas R. Houston   +3 more
wiley   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

Advanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi   +11 more
wiley   +1 more source

On the modifications of oscillator strengths and damping constants of Fe I spectral lines from 500 nm to 510 nm

, 2004
Atila Čeki, O. Latković, I. Vince
openalex   +2 more sources

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER‐Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance

Advanced Science, EarlyView.
Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang, Jiaqi Zhang, Xinyu Yang, Qiqi Zhang, Xiuya Hu, Xin Lu, Hanni Li, Xue Bai, Kai Zhang, Michael N. Sack, Yongsheng Chang, Yingmei Wang, Lingdi Wang, Lu Zhu   +13 more
wiley   +1 more source

Erratum to “Can pain be more or less neuropathic?” [Pain 110 (2004) 510–511]

, 2004
Nadine Attal, Didier Bouhassira
openalex   +1 more source

Single‐Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion

Advanced Science, EarlyView.
Single‐cell transcriptomics and clinical data show that during myasthenia gravis (MG) exacerbation, bone marrow mature neutrophils expand and enter blood, with parallel increase of B‐cell activating factor (BAFF)–positive neutrophils. Experimental autoimmune myasthenia gravis (EAMG) confirms a pathogenic interferon‐γ (IFN‐γ)–neutrophil–BAFF axis ...
Zhaoxu Zhang, Jingya Dong, Mengyuan Qiu, Jie Bai, Xufeng Cheng, Xiaodong Song   +5 more
wiley   +1 more source

Suppressing the Electron–Phonon Coupling in 2D Perovskite Cs3Sb2I9 for Lead‐Free Indoor Photovoltaics

Advanced Science, EarlyView.
The study has developed an in situ anion‐exchange strategy to fabricate Pb‐free Sb‐based perovskite‐inspired materials (Sb‐PIMs) and solar cells, achieving a record indoor efficiency of 8.2% and a 3.4% power conversion efficiency under 1 sun illumination.
Yixin Guo, Fei Zhao, Chuanjun Zhang, Ping Wu, Jinchun Jiang, Jiahua Tao, Junhao Chu   +6 more
wiley   +1 more source