Results 21 to 30 of about 1,686,692 (405)
Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.
Journal of Medicinal Chemistry, 2019 KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-"undruggable" target, however clinically viable inhibitors have ...
B. Lanman +43 more
semanticscholar +1 more source
Diagnostics, 2023 We would like to thank Dr. Ishikura for his kind comment [...]
Hideo Wada +3 more
doaj +1 more source
EPJ Web of Conferences, 2017 Inelastic neutron scattering from 56Fe was studied at the nELBE time-of-flight facility. The incoming neutron energy ranges from 100 keV to 10 MeV in the fast neutron spectrum, where high precision nuclear data are needed.
Dietz Mirco +12 more
doaj +1 more source
Microorganisms, 2023 Vaporized hydrogen peroxide (VHP) terminal sterilization is one of the most promising techniques for sterilizing temperature-sensitive medical instruments like endoscopes.
M. R. Karimi Estahbanati
doaj +1 more source
Review of approvals and recalls of US specific medical devices in general and plastic surgery
Surgery in Practice and Science, 2023 Background: Medical devices in the United States can be FDA approved either by the premarket notification (510(k)) or premarket approval process (PMA). Applications for PMA are more intensive than 510(k).
Aashka Shah +2 more
doaj
A counter-rotating core in the dwarf elliptical galaxy VCC 510 [PDF]
Astron.Astrophys.445:L19-L22,2006, 2005 We present optical long-slit spectra of the Virgo dwarf elliptical galaxy VCC 510 at high spectral and spatial resolution. Heliocentric velocities and velocity dispersions as functions of galaxy radius are derived by deconvolving line-of-sight velocity distributions.
arxiv +1 more source
Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice. [PDF]
PLoS ONE, 2013 Angiogenesis is an essential process for normal skeletal muscle function. There is a growing body of evidence suggesting that thrombospondin-1 (TSP-1), a potent antiangiogenic protein in tumorigenesis, is an important regulator of both physiological and ...
Gerald N Audet +3 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 The KRASG12C mutant is often associated with human cancers, and AMG 510 as a promising covalent inhibitor of KRASG12C has achieved surprising efficacy in clinical trials.
Yu Li, Lei Han, Ziding Zhang
doaj
LncRNA MIR4435-2HG inhibits the progression of osteoarthritis through miR-510-3p sponging
Experimental and Therapeutic Medicine, 2020 Osteoarthritis (OA) is a disorder of diarthrodial joints that can have multiple causes. Long non-coding RNAs (lncRNAs) participate in multiple diseases, including OA.
Yingli Liu +4 more
semanticscholar +1 more source
Food Security and Sustainability: Discussing the Four Pillars to Encompass Other Dimensions
Foods, 2021 The unadjusted intake of food constitutes a real challenge for the several sustainability dimensions. In this perspective, the main objectives of this research are to characterise the current contexts of food security, its relationship with ...
Raquel de Pinho Ferreira Guiné +5 more
doaj +1 more source