Results 21 to 30 of about 1,768,342 (381)

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

Journal of Medicinal Chemistry, 2019
KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-"undruggable" target, however clinically viable inhibitors have ...
B. Lanman, Jennifer R. Allen, J. Allen, A. Amegadzie, K. Ashton, S. Booker, J. Chen, N. Chen, M. Frohn, G. Goodman, D. J. Kopecky, Longbin Liu, Patricia Lopez, J. D. Low, V. Ma, A. Minatti, Thomas T. Nguyen, N. Nishimura, Alexander J. Pickrell, Anthony B. Reed, Y. Shin, Aaron C. Siegmund, N. Tamayo, C. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C Yang, Pragathi Achanta, M. Bartberger, J. Canon, L. Hollis, J. McCarter, C. Mohr, K. Rex, A. Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, D. Whittington, S. Zech, J. Lipford, V. Cee   +43 more
semanticscholar   +1 more source

Advances in Vaporized Hydrogen Peroxide Reusable Medical Device Sterilization Cycle Development: Technology Review and Patent Trends

Microorganisms, 2023
Vaporized hydrogen peroxide (VHP) terminal sterilization is one of the most promising techniques for sterilizing temperature-sensitive medical instruments like endoscopes.
M. R. Karimi Estahbanati
doaj   +1 more source

Angular distribution measurement of gamma rays from inelastic neutron scattering on 56Fe at the nELBE time-of-flight facility

EPJ Web of Conferences, 2017
Inelastic neutron scattering from 56Fe was studied at the nELBE time-of-flight facility. The incoming neutron energy ranges from 100 keV to 10 MeV in the fast neutron spectrum, where high precision nuclear data are needed.
Dietz Mirco, Bemmerer Daniel, Beyer Roland, Gohl Stefan, Junghans Arnd R., Kögler Toni, Massarczyk Ralph, Müller Stefan E., Schwengner Ronald, Szücs Tamás, Takacs Marcell P., Wagner Andreas, Wagner Louis   +12 more
doaj   +1 more source

Review of approvals and recalls of US specific medical devices in general and plastic surgery

Surgery in Practice and Science, 2023
Background: Medical devices in the United States can be FDA approved either by the premarket notification (510(k)) or premarket approval process (PMA). Applications for PMA are more intensive than 510(k).
Aashka Shah, Michelle M. Olson, Joseph M. Maurice   +2 more
doaj  

Reply to Ishikura, H. What Does Soluble C-Type Lectin-like Receptor 2 (sCLEC-2) × D-Dimer/Platelet (PLT) (sCLEC-2 × D-Dimer/PLT) Mean for Coagulation/Fibrinolysis Conditions? Comment on “Yamamoto et al. Super Formula for Diagnosing Disseminated Intravascular Coagulation Using Soluble C-Type Lectin-like Receptor 2. Diagnostics 2023, 13, 2299”

Diagnostics, 2023
We would like to thank Dr. Ishikura for his kind comment [...]
Hideo Wada, Akitaka Yamamoto, Katsuya Shiraki, Hideto Shimpo   +3 more
doaj   +1 more source

Full Neutralization of Centruroides sculpturatus Scorpion Venom by Combining Two Human Antibody Fragments

Toxins, 2021
A fundamental issue of the characterization of single-chain variable fragments (scFvs), capable of neutralizing scorpion toxins, is their cross-neutralizing ability. This aspect is very important in Mexico because all scorpions dangerous to humans belong
Lidia Riaño-Umbarila, José Alberto Romero-Moreno, Luis M. Ledezma-Candanoza, Timoteo Olamendi-Portugal, Lourival D. Possani, Baltazar Becerril   +5 more
doaj   +1 more source

Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation

Computational and Structural Biotechnology Journal, 2022
The KRASG12C mutant is often associated with human cancers, and AMG 510 as a promising covalent inhibitor of KRASG12C has achieved surprising efficacy in clinical trials.
Yu Li, Lei Han, Ziding Zhang
doaj  

LncRNA MIR4435-2HG inhibits the progression of osteoarthritis through miR-510-3p sponging

Experimental and Therapeutic Medicine, 2020
Osteoarthritis (OA) is a disorder of diarthrodial joints that can have multiple causes. Long non-coding RNAs (lncRNAs) participate in multiple diseases, including OA.
Yingli Liu, Yun Yang, L. Ding, Yuqin Jia, Yun Ji   +4 more
semanticscholar   +1 more source

Traumatic Lumbosacral Dislocation: Current Concepts in Diagnosis and Management

Advances in Orthopedics, 2018
Traumatic lumbosacral dislocation is a rare, high-energy mechanism injury characterized by displacement of the fifth lumbar vertebra in relation to the sacrum.
Andrew S. Moon, Kivanc Atesok, Thomas E. Niemeier, Sakthivel R. Manoharan, Jason L. Pittman, Steven M. Theiss   +5 more
doaj   +1 more source

Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice. [PDF]

PLoS ONE, 2013
Angiogenesis is an essential process for normal skeletal muscle function. There is a growing body of evidence suggesting that thrombospondin-1 (TSP-1), a potent antiangiogenic protein in tumorigenesis, is an important regulator of both physiological and ...
Gerald N Audet, Daniel Fulks, Janelle C Stricker, I Mark Olfert   +3 more
doaj   +1 more source