Results 41 to 50 of about 2,314,355 (337)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Quantum Ontologies and Mind-Matter Synthesis
, 1999 Aspects of a quantum mechanical theory of a world containing efficacious mental aspects that are closely tied to brains, but that are not identical to brains.Comment: 69 pages. Invited contribution to Xth Max Born Symposium: "Quantum Future". Published
A. Einstein +22 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Zhongguo shipin weisheng zazhi, 2020 Objective To study the serotype distribution and drug resistance of Salmonella isolates from diarrhea cases in Zhongshan City from 2016 to 2017. Methods Serotype of 540 strains of Salmonella spp.
Zhanhong YUAN +5 more
doaj +1 more source
The medieval ‘scientia' of structures: the rules of Rodrigo Gil de Hontañón [PDF]
, 2002 Medieval builders didn't have a scientific structural theory, however gothic cathedrals were not build without a theory. Gothic masters had a ‘scientia', a body of knowledge which permitted the safe design of their buildings.
Huerta Fernández, Santiago
core +1 more source
Wavelength- and material-dependent absorption in GaAs and AlGaAs microcavities [PDF]
, 2006 The quality factors of modes in nearly identical GaAs and Al_{0.18}Ga_{0.82}As microdisks are tracked over three wavelength ranges centered at 980 nm, 1460 nm, and 1600 nm, with quality factors measured as high as 6.62x10^5 in the 1600-nm band.
Hennessy, K. +7 more
core +2 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Mitigating bit flips or single event upsets in epilepsy neurostimulators
Epilepsy and Behavior Case Reports, 2016 Objectives: The objective of this study was to review software errors known as single event upsets (SEUs) or bit flips due to cosmic rays in epilepsy neurostimulators. Materials and methods: A case report of a single event upset or bit flip is discussed;
Alice X. Dong +4 more
doaj +1 more source
Characterization of low-noise quasi-optical SIS mixers for the submillimeter band [PDF]
, 1996 We report on the development of low-noise quasi-optical SIS mixers for the frequency range 400-850 GHz. The mixers utilize twin-slot antennas, two-junction tuning circuits, and Nb-trilayer junctions. Fourier-transform spectrometry has been used to verify
Bin, Mei +5 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source