Results 1 to 10 of about 1,901,617 (293)
Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica [PDF]
Microorganisms, 2020 Bacterial natural products (NPs) are still a major source of new drug leads. Polyketides (PKs) and non-ribosomal peptides (NRP) are two pharmaceutically important families of NPs and recent studies have revealed Antarctica to harbor endemic polyketide ...
Adriana Rego +6 more
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Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens [PDF]
Frontiers in Fungal Biology, 2022 Natural products (NPs) and their derivatives are a major contributor to modern medicine. Historically, microorganisms such as bacteria and fungi have been instrumental in generating drugs and lead compounds because of the ease of culturing and ...
Garima Singh +8 more
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Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
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Molecules, 2015 Glucosinolates are anti-carcinogenic, anti-oxidative biochemical compounds that defend plants from insect and microbial attack. Glucosinolates are abundant in all cruciferous crops, including all vegetable and oilseed Brassica species.
Go-Eun Yi +6 more
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Biosynthetic genes for aminoglycoside antibiotics [PDF]
Journal of Antibiotics, 2009 Biosynthetic studies of aminoglycoside antibiotics have progressed remarkably during the last decade. Many biosynthetic gene clusters for aminoglycoside antibiotics including streptomycin, kanamycin, butirosin, neomycin and gentamicin have been identified to date.
Fumitaka Kudo, Tadashi Eguchi
exaly +3 more sources
Origin of saxitoxin biosynthetic genes in cyanobacteria. [PDF]
PLoS ONE, 2009 BACKGROUND:Paralytic shellfish poisoning (PSP) is a potentially fatal syndrome associated with the consumption of shellfish that have accumulated saxitoxin (STX). STX is produced by microscopic marine dinoflagellate algae.
Ahmed Moustafa +5 more
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ArpA-like regulatory control and discovery of new biosynthetic genes driving scleric acid biosynthesis [PDF]
RSC Chemical BiologyScleric acid is a natural product that was discovered by heterologous expression of the silent scl gene cluster from Streptomyces sclerotialus in Streptomyces albidoflavus and rational de-repression of the biosynthetic genes through deletion of the ArpA ...
Jingfan Zhang +4 more
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Molecules, 2016 Glucosinolates are the biochemical compounds that provide defense to plants against pathogens and herbivores. In this study, the relative expression level of 48 glucosinolate biosynthesis genes was explored in four morphologically-different cabbage ...
Arif Hasan Khan Robin +6 more
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Frontiers in Bioengineering and Biotechnology, 2020 8-Azaguanine (1) is a special 1,2,3-triazole containing natural product that possesses potent antibacterial and antitumor activities. In the present study, the entire 8-azaguanine biosynthetic gene cluster was located from Streptomyces CGMCC4.1633 ...
Feifei Hou +6 more
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Creation of high‐resistant starch rice through systematic editing of amylopectin biosynthetic genes in rs4 [PDF]
Plant Biotechnology JournalJiayang Li, Hong Yu, Anqi Wang
exaly +2 more sources