Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens [PDF]
Frontiers in Fungal Biology, 2022 Natural products (NPs) and their derivatives are a major contributor to modern medicine. Historically, microorganisms such as bacteria and fungi have been instrumental in generating drugs and lead compounds because of the ease of culturing and ...
Garima Singh +8 more
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Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica [PDF]
Microorganisms, 2020 Bacterial natural products (NPs) are still a major source of new drug leads. Polyketides (PKs) and non-ribosomal peptides (NRP) are two pharmaceutically important families of NPs and recent studies have revealed Antarctica to harbor endemic polyketide ...
Adriana Rego +6 more
doaj +6 more sources
Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
doaj +3 more sources
Molecules, 2015 Glucosinolates are anti-carcinogenic, anti-oxidative biochemical compounds that defend plants from insect and microbial attack. Glucosinolates are abundant in all cruciferous crops, including all vegetable and oilseed Brassica species.
Go-Eun Yi +6 more
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Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen. [PDF]
Nat CommunCoevolutionary antagonism generates relentless selection that can favour genetic exchange, including transfer of antibiotic synthesis and resistance genes among bacteria, and sexual recombination of disease resistance alleles in eukaryotes.
Nowell RW +6 more
europepmc +2 more sources
De Novo Genome Assembly of Toniniopsis dissimilis (Ramalinaceae, Lecanoromycetes) from Long Reads Shows a Comparatively High Composition of Biosynthetic Genes Putatively Involved in Melanin Synthesis. [PDF]
Genes (Basel)Lichens have developed numerous adaptations to optimize their survival in various environmental conditions, largely by producing secondary compounds by the fungal partner.
Gerasimova JV +3 more
europepmc +2 more sources
Journal of Plant Interactions, 2022 Peanut (Arachis hypogaea L.) harbors a plethora of flavonoids that impart its health-promoting properties. To understand its biosynthesis and accumulation, a comparative expression analysis of flavonoid biosynthetic genes encoding enzymes responsible for
Maryam Khan +9 more
doaj +2 more sources
Molecules, 2016 Glucosinolates are the biochemical compounds that provide defense to plants against pathogens and herbivores. In this study, the relative expression level of 48 glucosinolate biosynthesis genes was explored in four morphologically-different cabbage ...
Arif Hasan Khan Robin +6 more
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Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans. [PDF]
PLoS ONE, 2014 Coenzyme Q (CoQ) is an essential factor for aerobic growth and oxidative phosphorylation in the electron transport system. The biosynthetic pathway for CoQ has been proposed mainly from biochemical and genetic analyses of Escherichia coli and ...
Kazuhiro Hayashi +5 more
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Lipid biosynthetic genes and a ribosomal protein gene are cotranscribed [PDF]
FEBS Letters, 1995 By using insertional mutagenesis we demonstrated that the rpmF gene encoding ribosomal protein L32, the plsX gene encoding a protein involved in membrane lipid synthesis and several fatty acid biosynthetic genes (fabH, fabD and fabG) are cotranscribed ...
Larson, Timothy J., Podkovyrov, Sergey
core +3 more sources