Results 11 to 20 of about 245,069 (308)
Molecules, 2020 PF-543, the most potent sphingosine kinase (SK) inhibitor, does not demonstrate effective anticancer activity in some cancer cells, unlike other known SK1 inhibitors.
Sung Hwan Ki, Yoon Sin Oh, Joo-Youn Lee
exaly +3 more sources
Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load. [PDF]
PLoS Neglected Tropical DiseasesBackgroundSphingosine-1-phosphate (S1P) is a bioactive lipid mediator regulating apoptosis, proliferation, and immune responses. While S1Ps presence in Leishmania donovani phagolysosomes has been reported, the role of sphingosine kinases, especially ...
Evanka Madan +7 more
doaj +2 more sources
Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer [PDF]
BMC GastroenterologyBackground To analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).
Ziwei Wang +3 more
doaj +2 more sources
Molecular Therapy - Nucleic Acids, 2021 Long non-coding RNAs (lncRNAs) regulate the development of follicles and reproductive diseases, but the mechanisms by which lncRNAs regulate ovarian functions and fertility remain elusive.
Xiaolei Yao +2 more
exaly +3 more sources
ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis
Molecular Therapy - Nucleic Acids, 2020 Breast cancer is the most common malignancy, and metastasis is the main cause of cancer-associated mortality in women worldwide. Transforming growth factor-β (TGF-β) signaling, an inducer of epithelial-to-mesenchymal transition (EMT), plays an important ...
Wei Ji, Qiang Mu, Xiangyu Liu
exaly +3 more sources
Recording the direct surgeon’s view with an operating microscopic view improves microscopic ophthalmic surgery training [PDF]
International Journal of Ophthalmology, 2023 AIM: To establish a recording system with a direct view of the surgeon to supplement video recording under an operating microscope, which lacks information on the movement and position of the surgeon's hands, and to facilitate the reproduction of a ...
Masayuki Akimoto +3 more
doaj +1 more source
Children, 2021 The World Health Organization (WHO) acknowledged that, as health services divert their attention to the COVID-19 pandemic, the delivery of essential nutrition services may be compromised.
Ferima Coulibaly-Zerbo +17 more
doaj +1 more source
Diagnostics, 2021 Background: Noninvasive prenatal genetic testing (NIPT) has been adopted as the first choice for aneuploidy screening. The purposes of this study were to investigate the accuracy of Vanadis® NIPT (hereafter CRITO-NIPT) in order to gain a deeper insight ...
Ritsuko Kimata Pooh +11 more
doaj +1 more source
D-karyo—A New Prenatal Rapid Screening Test Detecting Submicroscopic CNVs and Mosaicism
Diagnostics, 2021 Chromosomal microarray analysis (CMA), recently introduced following conventional cytogenetic technology, can detect submicroscopic copy-number variations (CNVs) in cases previously diagnosed as “cytogenetically benign”.
Osamu Shimokawa +8 more
doaj +1 more source
Surgeries, 2022 Here, we report a new surgical technique designed to increase filtration volume and reduce intraocular pressure (IOP) in glaucoma and its one-year outcome.
Kosei Tomita +4 more
doaj +1 more source