Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 [PDF]
Journal of Immunology Research, 2022 Objective. Ovarian cancer (OvCa) is the most lethal gynaecological malignancy worldwide. We aimed to illustrate the potential function and molecular mechanism of exosomal microRNA-543 (miR-543) in the oncogenesis and development of OvCa.
Shupei Zhang +10 more
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miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8 [PDF]
BMC Nephrology, 2022 Background Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which can lead to renal failure and fatality. miRNAs are an important class of endogenous non-coding RNAs implicated in a wide range of biological ...
Langen Zhuang +5 more
doaj +5 more sources
LncRNA PVT1 Regulates TRPS1 Expression in Breast Cancer by Sponging miR-543 [PDF]
Cancer Management and Research, 2020 Hongtao Wang,1,* Yuanli Huang,2,* Yuanrong Yang1 1Department of Pharmacy, The Second Clinical Medical College, Yangtze University, Jingzhou 434020, People’s Republic of China; 2Department of Galactophore, The Second Clinical Medical College ...
Wang H, Huang Y, Yang Y
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LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN [PDF]
Cancer Medicine, 2020 Long intergenic nonprotein coding RNA p53‐induced transcript (LINC‐PINT) has been reported to participate in various cancers. Here, we investigated the effects of LINC‐PINT on lung cancer progression.
Shu Wang +7 more
doaj +5 more sources
Dysregulation of miR-543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1. [PDF]
Neuropathol Appl Neurobiol, 2023 Abstract Aims Parkinson's disease (PD) is a progressive and age‐dependent neurodegenerative disease characterised clinically by a variety of motor symptoms and cognitive impairment. PD was initially considered to be a grey matter disease; however, recently, evidence has emerged that white ...
Scheper M +5 more
europepmc +6 more sources
Long noncoding RNA SNHG6 promotes the malignant phenotypes of ovarian cancer cells via miR-543/YAP1 pathway [PDF]
Heliyon, 2023 The long non-coding RNA small nucleolar RNA host gene 6 (SNHG6) acts as an oncogene in several cancers, and is highly expressed in ovarian cancer. MiR-543, a tumor suppressor, was expressed lowly in ovarian cancer.
Mengya Su, Ping Huang, Qian Li
doaj +2 more sources
circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis [PDF]
Open Medicine, 2023 Circular RNA (circRNA) THBS1 has been shown to exist as an oncogene in non-small-cell lung cancer, but its role in cervical cancer is still unclear. Our experiment aimed to uncover the functions and specific mechanism of circRNA THBS1 in cervical cancer ...
Tian Rui +5 more
doaj +2 more sources
Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543 [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Rheumatoid arthritis (RA) is inflammatory arthritic disease, and circular RNA is involved in RA development. The aim of the present work is to analyze the role of circ_0002984 in the process of RA fibroblast-like synoviocytes (RAFLSs) and the ...
Jian-zuo Lu +3 more
doaj +2 more sources
GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer [PDF]
Mediators of Inflammation, 2023 Gastric cancer (GC) is one of the most common and lethal cancers worldwide. In view of the prominent roles of long noncoding RNAs (lncRNAs) in cancers, we investigated the specific role and underlying mechanism of GATA binding protein 6 antisense RNA 1 ...
Yi Jin, Daqing Jiang
doaj +2 more sources
miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. [PDF]
JCI Insight, 2020 Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAK V617F
Fuentes-Mattei E +29 more
europepmc +7 more sources