Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543 [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Rheumatoid arthritis (RA) is inflammatory arthritic disease, and circular RNA is involved in RA development. The aim of the present work is to analyze the role of circ_0002984 in the process of RA fibroblast-like synoviocytes (RAFLSs) and the ...
Jian-zuo Lu +3 more
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GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer [PDF]
Mediators of Inflammation, 2023 Gastric cancer (GC) is one of the most common and lethal cancers worldwide. In view of the prominent roles of long noncoding RNAs (lncRNAs) in cancers, we investigated the specific role and underlying mechanism of GATA binding protein 6 antisense RNA 1 ...
Yi Jin, Daqing Jiang
doaj +3 more sources
miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. [PDF]
JCI Insight, 2020 Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAKV617F mutation) have been implicated in the etiology of MF, but the molecular mechanism causing resistance to ...
Fuentes-Mattei E +29 more
europepmc +9 more sources
CircAgtpbp1 Acts as a Molecular Sponge of miR-543-5p to Regulate the Secretion of GH in Rat Pituitary Cells [PDF]
Animals, 2021 CircRNAs have been identified to be expressed differently and stably in numerous species and tissues, but their functions in growth hormone (GH) secretion are still largely unknown.
ZeWen Yu +7 more
doaj +3 more sources
Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer [PDF]
BMC GastroenterologyBackground To analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).
Ziwei Wang +3 more
doaj +2 more sources
MiR-543 promotes tumorigenesis and angiogenesis in non-small cell lung cancer via modulating metastasis associated protein 1 [PDF]
Molecular Medicine, 2020 Objective This study is aimed to explore the role of miR-543 in non-small cell lung cancer (NSCLC), and verify whether miR-543 targets metastasis associated protein 1 (MTA1) to affect tumorigenesis and angiogenesis in NSCLC.
Dawei Wang +3 more
doaj +2 more sources
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment [PDF]
Stem Cell Research & Therapy, 2022 Background Periodontal ligament stem cells (PDLSCs) are the ideal seed cells for periodontal tissue regeneration. It is well established that persistent inflammation significantly impairs the osteogenic differentiation capability of PDLSCs.
Xinyuan Zhao +3 more
doaj +2 more sources
Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR. [PDF]
Onco Targets Ther, 2021 A large body of evidence has shown that circular RNAs (circRNAs) play a significant role in the progression of some malignant cancers, including hepatocellular carcinoma (HCC). However, the complex mechanism of circRNAs in hepatocellular carcinoma has not been clarified.We identified circRNAs by microarray analysis and quantitative real-time polymerase
Gu Y +5 more
europepmc +5 more sources
Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis [PDF]
Journal of Orthopaedic Surgery and Research, 2020 Background Rheumatoid arthritis (RA), a kind of autoimmune disorder, is featured by many physical symptoms and proliferation of fibroblast-like synoviocytes (FLSs). The relevance of long non-coding RNAs (lncRNAs) in the progression of RA has been probed.
Junxia Wang +3 more
doaj +2 more sources
LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4. [PDF]
Transl Cancer Res, 2020 Emerging evidence shows that long non-coding RNAs (lncRNAs) play a crucial role in tumor development by regulating biological behavior in various cancer cells. Several lncRNAs act as miRNA sponges by binding miRNA sequences and thus regulating mRNA expression.
Ning J +5 more
europepmc +4 more sources