Results 31 to 40 of about 5,727 (227)

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway. [PDF]

J Cancer, 2019
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as a sensitizer for oxaliplatin (L-OHP) chemoresistant CRC cells.
Liang Y, Zhu D, Zhu L, Hou Y, Hou L, Huang X, Li L, Wang Y, Li L, Zou H, Wu T, Yao M, Wang J, Meng X.   +13 more
europepmc   +3 more sources

MicroRNA-543 in systemic diseases and possible applications in gynecologic tumors

Reproductive and Developmental Medicine, 2021
In recent years, an increasing number of young women have been diagnosed with cancer, including some nulliparous women. Therefore, many young patients with early-stage cancer desire to preserve fertility after cytotoxic oncological treatments.
Yan-Ran Sheng, Wen-Ting Hu, Chun-Yan Wei, Yu-Kai Liu, Yu-Yin Liu, Xiao-Yong Zhu   +5 more
doaj   +1 more source

Effects of LncRNA MEG3 on immunity and autophagy of non-small cell lung carcinoma through IDO signaling pathway

World Journal of Surgical Oncology, 2021
Background The study was done to investigate the effect of LncRNA MEG3 on the immunity and autophagy of non-small cell lung carcinoma through the IDO signaling pathway. Methods A total of 78 cases of early NSCLC patients (research group; RG) and 69 cases
Chuanqiang Wang, Xiangbo Tao, Jungong Wei   +2 more
doaj   +1 more source

Role and Possible Mechanism of LncRNA-MEG3 and KLF4 in Carcinogenesis and Progression of Nasopharyngeal Carcinoma

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the role of LncRNAs-MEG3 in the carcinogenesis and progression of nasopharyngeal carcinoma (NPC) and the possible molecular mechanism. Methods qRT-PCR was used to detect the content of MEG3 and miR-543 in NPC cells.
NING Jiayu, BAO Weiijing, ZHOU Sujuan, WEI Rifu, ZHU Zhongshou   +4 more
doaj   +1 more source

miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2 [PDF]

JCI Insight
Enrique Fuentes-Mattei, Recep Bayraktar, Taghi Manshouri, Andreia M. Silva, Cristina Ivan, Diana Gulei, Linda Fabris, Nayra Soares do Amaral, Pilar Mur, Cristina Perez, Elizabeth Torres-Claudio, Mihnea P. Dragomir, Adriana Badillo-Perez, Erik Knutsen, Pranav Narayanan, Leonard Golfman, Masayoshi Shimizu, Xinna Zhang, Wanke Zhao, Wanting Tina Ho, Marcos Roberto Estecio, Geoffrey Bartholomeusz, Ciprian Tomuleasa, Ioana Berindan-Neagoe, Patrick A. Zweidler-McKay, Zeev Estrov, Zhizhuang J. Zhao, Srdan Verstovsek, George A. Calin, Roxana S. Redis   +29 more
doaj   +2 more sources

Bioinformatics Analysis of Stem Cell circ-ASB3 Signaling Pathway and Its Affection on Glioma Biological Characteristics

Frontiers in Neuroinformatics, 2022
ObjectiveIn our research we try to explore whether glioma stem cell containing circRNAs signal pathway could regulate glioma malignant progression and elaborate its possible mechanism.MethodsIn this study, we used biological information analysis to build
Li Guowei, Jin Yanping
doaj   +1 more source

MiR-543 Promotes Migration, Invasion and Epithelial-Mesenchymal Transition of Esophageal Cancer Cells by Targeting Phospholipase A2 Group IVA

Cellular Physiology and Biochemistry, 2018
Background/Aims: The aim of this study was to investigate the roles of miR-543 and phospholipase A2 group IVA (PLA2G4A) in cell mobility and the invasiveness cascade in esophageal squamous cell carcinoma (ESCC) and to validate the interactive ...
Huaying Zhao, Changying Diao, Xiaohui Wang, Yilin Xie, Yaqing Liu, Xianzheng Gao, Jing Han, Shenglei Li   +7 more
doaj   +1 more source

Integrated analysis of lncRNA-associated ceRNA network identified potential regulatory interactions in osteosarcoma [PDF]

Genetics and Molecular Biology, 2020
This study aimed to identify potential therapeutic targets in osteosarcoma (OS) through the network analysis of competing endogenous RNAs (ceRNAs). The differentially expressed miRNAs (DEMIs) and mRNAs (DEMs) were identified between OS cell lines and ...
Yongwei Wang, Yaxian Gao, Sen Guo, Zhihong Chen   +3 more
doaj   +2 more sources

Design of crRNA to Regulate MicroRNAs Related to Metastasis in Colorectal Cancer Using CRISPR-C2c2 (Cas13a) Technique [PDF]

Cell Journal, 2023
Colorectal cancer (CRC) is the third most prevalent cancer with the second-highest mortality rate worldwide. microRNAs(miRNAs) of cancer-derived exosomes have shown promising diagnosis potential.
Seyed Taleb Houseini, Farkhondeh Nemati, Arash Sattari, Mansoureh Azadeh, Roya BishehKolaei   +4 more
doaj   +1 more source

Endometrial MIR-543 is down-regulated during the implantation window in women with endometriosis-related infertility [PDF]

Fertility and Sterility, 2018
Differentially expressed microRNAs (miRNAs) and their target mRNAs may lead to alterations in normal physiological status of the tissues and initiate pathological processes. The aim of this study was to investigate the expression of the most relevant miRNAs in the eutopic endometrial tissue during the window of implantation in women with endometriosis ...
Puyu, Yang, Zhangxin, Wu, Caihong, Ma, Ningning, Pan, Yang, Wang, Liying, Yan   +5 more
openaire   +2 more sources