Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 [PDF]
Journal of Immunology Research, 2022 Objective. Ovarian cancer (OvCa) is the most lethal gynaecological malignancy worldwide. We aimed to illustrate the potential function and molecular mechanism of exosomal microRNA-543 (miR-543) in the oncogenesis and development of OvCa.
Shupei Zhang +10 more
doaj +5 more sources
circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis [PDF]
Open Medicine (Poland), 2023 Circular RNA (circRNA) THBS1 has been shown to exist as an oncogene in non-small-cell lung cancer, but its role in cervical cancer is still unclear. Our experiment aimed to uncover the functions and specific mechanism of circRNA THBS1 in cervical cancer ...
Rui Tian
exaly +4 more sources
Dysregulation of miR-543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1. [PDF]
Neuropathol Appl Neurobiol, 2023 Abstract Aims Parkinson's disease (PD) is a progressive and age‐dependent neurodegenerative disease characterised clinically by a variety of motor symptoms and cognitive impairment. PD was initially considered to be a grey matter disease; however, recently, evidence has emerged that white ...
Scheper M +5 more
europepmc +8 more sources
Long noncoding RNA SNHG6 promotes the malignant phenotypes of ovarian cancer cells via miR-543/YAP1 pathway [PDF]
Heliyon, 2023 The long non-coding RNA small nucleolar RNA host gene 6 (SNHG6) acts as an oncogene in several cancers, and is highly expressed in ovarian cancer. MiR-543, a tumor suppressor, was expressed lowly in ovarian cancer.
Mengya Su
exaly +4 more sources
miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8 [PDF]
BMC Nephrology, 2022 Background Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which can lead to renal failure and fatality. miRNAs are an important class of endogenous non-coding RNAs implicated in a wide range of biological ...
Langen Zhuang +5 more
doaj +5 more sources
MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du +5 more
doaj +5 more sources
lncRNA FDNCR promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-β signaling pathway in Hu sheep [PDF]
Molecular Therapy - Nucleic Acids, 2021 Long non-coding RNAs (lncRNAs) regulate the development of follicles and reproductive diseases, but the mechanisms by which lncRNAs regulate ovarian functions and fertility remain elusive.
Xiaolei Yao +2 more
exaly +4 more sources
ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis [PDF]
Molecular Therapy - Nucleic Acids, 2020 Breast cancer is the most common malignancy, and metastasis is the main cause of cancer-associated mortality in women worldwide. Transforming growth factor-β (TGF-β) signaling, an inducer of epithelial-to-mesenchymal transition (EMT), plays an important ...
Wei Ji, Qiang Mu, Xiangyu Liu
exaly +4 more sources
LncRNA PVT1 Regulates TRPS1 Expression in Breast Cancer by Sponging miR-543 [PDF]
Cancer Management and Research, 2020 Hongtao Wang,1,* Yuanli Huang,2,* Yuanrong Yang1 1Department of Pharmacy, The Second Clinical Medical College, Yangtze University, Jingzhou 434020, People’s Republic of China; 2Department of Galactophore, The Second Clinical Medical College ...
Wang H, Huang Y, Yang Y
doaj +5 more sources
Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells. [PDF]
PLoS ONE, 2019 Growth hormone (GH) is an important hormone released by the pituitary gland that plays a key role in the growth and development of organisms. In our study, TargetScan analysis and the dual luciferase reporter assays were used to predict and screen for ...
Ze-Wen Yu +9 more
doaj +3 more sources