Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment [PDF]
Stem Cell Research & Therapy, 2022 Background Periodontal ligament stem cells (PDLSCs) are the ideal seed cells for periodontal tissue regeneration. It is well established that persistent inflammation significantly impairs the osteogenic differentiation capability of PDLSCs.
Xinyuan Zhao +3 more
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Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis [PDF]
Journal of Orthopaedic Surgery and Research, 2020 Background Rheumatoid arthritis (RA), a kind of autoimmune disorder, is featured by many physical symptoms and proliferation of fibroblast-like synoviocytes (FLSs). The relevance of long non-coding RNAs (lncRNAs) in the progression of RA has been probed.
Junxia Wang +3 more
doaj +2 more sources
CTGF promotes osteosarcoma angiogenesis by regulating miR-543/angiopoietin 2 signaling.
Cancer Letters, 2017 [[abstract]]Osteosarcoma is the most common primary solid tumor of bone. It has a high metastatic potential and occurs predominantly in adolescents and young adults.
Wang LH;Tsai HC;Cheng YC;Lin CY;黃元勵;HUANG,YUAN-LI;Tsai CH;Xu GH;Wang SW; Fong YC;Tang CH
core +3 more sources
MiR-543/SNTB1 axis modulates immune microenvironment in colorectal cancer
陆军军医大学学报Objective To investigate the clinical significance of the miR-543/syntrophin beta 1 (SNTB1) axis in colorectal cancer (CRC) and its influence on the tumor immune microenvironment.
ZHANG Min, LI Min, XIAO Meng
doaj +2 more sources
Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR. [PDF]
Onco Targets Ther, 2021 A large body of evidence has shown that circular RNAs (circRNAs) play a significant role in the progression of some malignant cancers, including hepatocellular carcinoma (HCC). However, the complex mechanism of circRNAs in hepatocellular carcinoma has not been clarified.We identified circRNAs by microarray analysis and quantitative real-time polymerase
Gu Y +5 more
europepmc +5 more sources
m5C modification of LINC01082 inhibits osteosarcoma progression by modulating the miR-543-TNRC6A axis. [PDF]
Transl OncolOsteosarcoma (OS) is a highly malignant bone tumor primarily affecting children and adolescents, with a significant portion of patients developing metastasis, leading to poor prognosis. Recent studies have identified long noncoding RNAs (lncRNAs) as critical regulators in cancer progression.
Hu Y +8 more
europepmc +4 more sources
miR‑543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5. [PDF]
Oncol Rep, 2019 MicroRNAs (miRNAs/miRs) are small non‑coding RNAs that can act as oncogenes or tumor‑suppressor genes in human cancer. Previous studies have revealed that abnormal expression of miRNAs is closely associated with tumor cell cycle, differentiation, growth and apoptosis.
Wang L +7 more
europepmc +4 more sources
LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4. [PDF]
Transl Cancer Res, 2020 Emerging evidence shows that long non-coding RNAs (lncRNAs) play a crucial role in tumor development by regulating biological behavior in various cancer cells. Several lncRNAs act as miRNA sponges by binding miRNA sequences and thus regulating mRNA expression.
Ning J +5 more
europepmc +4 more sources
miR-543 Inhibits the Occurrence and Development of Intrauterine Adhesion by Inhibiting the Proliferation, Migration, and Invasion of Endometrial Cells. [PDF]
Biomed Res Int, 2021 Objective. To explore the function of miR‐543 in endometrial cells and the possible mechanism of regulating the occurrence and development of intrauterine adhesion. Method. Endometrial epithelial cells and endometrial adenocarcinoma cells were transfected with miR‐543 mimics and miR‐543 inhibitor as the experimental group and were tested with the ...
Liu X, Xu Q, Chen C, Duan H.
europepmc +4 more sources
miR-543 functions as a tumor suppressor in glioma in vitro and in vivo. [PDF]
Oncol Rep, 2017 Gliomas are the most common primary central nervous system tumors and account for approximately 80% of malignant brain tumors. MicroRNAs (miRNAs) are a class of small non-coding, regulatory RNA molecules that mediate the expression levels of specific proteins.
Xu L +5 more
europepmc +4 more sources