MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du +5 more
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miR‑543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5. [PDF]
Oncol Rep, 2019 MicroRNAs (miRNAs/miRs) are small non‑coding RNAs that can act as oncogenes or tumor‑suppressor genes in human cancer. Previous studies have revealed that abnormal expression of miRNAs is closely associated with tumor cell cycle, differentiation, growth and apoptosis.
Wang L +7 more
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miR-543 Inhibits the Occurrence and Development of Intrauterine Adhesion by Inhibiting the Proliferation, Migration, and Invasion of Endometrial Cells. [PDF]
Biomed Res Int, 2021 Objective. To explore the function of miR‐543 in endometrial cells and the possible mechanism of regulating the occurrence and development of intrauterine adhesion. Method. Endometrial epithelial cells and endometrial adenocarcinoma cells were transfected with miR‐543 mimics and miR‐543 inhibitor as the experimental group and were tested with the ...
Liu X, Xu Q, Chen C, Duan H.
europepmc +4 more sources
miR-543 functions as a tumor suppressor in glioma in vitro and in vivo. [PDF]
Oncol Rep, 2017 Gliomas are the most common primary central nervous system tumors and account for approximately 80% of malignant brain tumors. MicroRNAs (miRNAs) are a class of small non-coding, regulatory RNA molecules that mediate the expression levels of specific proteins.
Xu L +5 more
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Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival. [PDF]
Cancer Med, 2020 AbstractPancreatic cancer (PC) is one of the most malignant gastrointestinal tumors and the 5‐year survival is only 9%. The expression of miRNAs in serum has been proved to be related to tumorigenesis and development of cancers. The miRNA targets and gene targets were predicted in microRNA.org, miRDB, TargetScan, and RNAInter.
Yuan W +6 more
europepmc +4 more sources
miR-543 promotes colorectal cancer proliferation and metastasis by targeting KLF4. [PDF]
Oncotarget, 2017 Till now, miR-543 expression has been demonstrated to be involved in the development of some cancers. However, reports about its expression and mechanism in colorectal cancer (CRC) were conflicting [1, 2]. Here, we investigated clinical implications of miR-543 and mechanisms underlying miR-543-mediated CRC development.
Zhai F, Cao C, Zhang L, Zhang J.
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Placental Growth Factor Promotes Metastases of Ovarian Cancer Through MiR-543-Regulated MMP7
Cellular Physiology and Biochemistry, 2015 Background/Aims: Elucidation of the molecular mechanisms underlying ovarian cancer (OC) cell invasion and migration may provide important evidence for developing efficient therapy.
Ning Song +3 more
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Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells. [PDF]
PLoS ONE, 2019 Growth hormone (GH) is an important hormone released by the pituitary gland that plays a key role in the growth and development of organisms. In our study, TargetScan analysis and the dual luciferase reporter assays were used to predict and screen for ...
Ze-Wen Yu +9 more
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MiR-543/SNTB1 axis modulates immune microenvironment in colorectal cancer
陆军军医大学学报Objective To investigate the clinical significance of the miR-543/syntrophin beta 1 (SNTB1) axis in colorectal cancer (CRC) and its influence on the tumor immune microenvironment.
ZHANG Min, LI Min, XIAO Meng
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Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3. [PDF]
PLoS ONE, 2018 Molecular chaperones are important regulators of protein folding and proteasomal removal of misfolded proteins. In spinocerebellar ataxia type 3 (SCA3), the co-chaperone DnaJ homology subfamily B member 1 (DNAJB1 or heat shock protein 40) is recruited to
Bernd O Evert +9 more
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