Results 1 to 10 of about 1,582 (158)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies [PDF]

Molecular Oncology
Lung adenocarcinoma (LUAD), the most common subtype of non‐small‐cell lung cancer (NSCLC), is often driven by mutations, particularly in epidermal growth factor receptor (EGFR), that guide targeted therapy choices. However, resistance to these treatments
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. daSilva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
doaj   +3 more sources

Manipulating RKIP reverses the metastatic potential of breast cancer cells [PDF]

Frontiers in Oncology, 2023
Breast cancer is a common tumor type among women, with a high fatality due to metastasis. Metastasis suppressors encode proteins that inhibit the metastatic cascade independent of the primary tumor growth.
Trang Huyen Lai, Mahmoud Ahmed, Jin Seok Hwang, Md Entaz Bahar, Trang Minh Pham, Jinsung Yang, Wanil Kim, Rizi Firman Maulidi, Dong-Kun Lee, Dong-Hee Kim, Hyun Joon Kim, Deok Ryong Kim   +11 more
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Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis [PDF]

Cancer Cell International, 2023
Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options.
Nathália Cristina Campanella, Izabela Natalia Faria Gomes, Ana Laura Vieira Alves, Leticia Ferro Leal, Adriane Feijó Evangelista, Marcela Nunes Rosa, Matias Eliseo Melendez, Viviane Aline Oliveira Silva, Richard Lucas Konichi Dias, Lucas Faria Abrahão-Machado, Iara Santana, Olga Martinho, Denise Peixoto Guimarães, Vitor Marcel Faça, Rui Manuel Reis   +14 more
doaj   +2 more sources

Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD [PDF]

Nature Communications
High-fat diet (HFD) is a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), yet the molecular pathways that connect dietary fats to liver dysfunction remain unclear.
Mengjie Li, Qian Ou, Qiang Qin, Jiaxi Chen, Sen Yang, Jie Zhao, Hua Meng, Xu Li, Pinglong Xu, Cunqi Ye, Xiaojian Wang   +10 more
doaj   +2 more sources

Unraveling the RKIP–YY1 axis: immune crosstalk in the pathogenesis of metabolic disorders [PDF]

Frontiers in Immunology
Metabolic diseases, including obesity, type 2 diabetes, and cardiovascular disorders, are increasingly recognized as chronic inflammatory conditions driven by dysregulated immune-metabolic interactions.
Fawaz Alzaid, Fawaz Alzaid, Hossein Arefanian, Fatemah Bahman, Shaima Albeloushi, Ghadeer Alhamar, Anwar Mohammad, Amal Hasan, Ashraf Al Madhoun, Rasheed Ahmad, Fahd Al-Mulla   +10 more
doaj   +2 more sources

The Role of Raf Kinase Inhibitor Protein (RKIP) in HER2+ Breast Cancer Immune Evasion [PDF]

Cells
Breast cancer (BC) is a prevalent malignancy worldwide among women. HER2 overexpression in a subset of BC (HER2+ BC) serves as a critical oncogenic driver and contributes to immune evasion. The Raf Kinase Inhibitor Protein (RKIP), a metastasis suppressor
Ania Khachikian, Mai Ho, Benjamin Bonavida   +2 more
doaj   +2 more sources

RKIP regulates bone marrow macrophage differentiation to mediate osteoclastogenesis and H-type vessel formation [PDF]

Nature Communications
As central cells involved in osteoimmunology, bone niche macrophages possess diverse functions, and their differentiation fate regulates bone homeostasis.
Zeyu Zheng, Siyue Tao, Jiayan Jin, Yansong Li, Liya Dai, Zhaobo Huang, Yihao Zhao, Bao Huang, Saijilafu, Wenlong Lin, Xiaojian Wang, Mengrui Wu, Jian Chen, Fengdong Zhao   +13 more
doaj   +2 more sources

The cross-talk between GSK-3β, RKIP, and PTEN as potential targets for therapeutic implications in cancer: a comprehensive insight [PDF]

Journal of Pharmacy & Pharmaceutical Sciences
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. In some cases, suppression of GSK-3 activity by phosphorylation by Akt and other kinases has been associated with
Esraa M. Mosalam, Mahmoud S. Abdallah, Mahmoud S. Abdallah, Ahmed R. Gardouh, Eman Hamza, Mostafa M. Bahaa, Mostafa M. Bahaa, Mahmoud Nazih, Mahmoud Nazih, Reham A. Al-Dhelaan, Noha Kamal   +10 more
doaj   +2 more sources

Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro [PDF]

Molecules
As a scaffolding protein, Raf kinase binding protein (RKIP) is involved in a variety of cellular pathways, including the Raf–MEK–ERK-cascade. It acts as a negative regulator by binding to its partners, making it an attractive target in the development of
Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You   +6 more
doaj   +2 more sources

The protease inhibitor gabexate mesylate targets Raf kinase inhibitor protein and reverses epithelial–mesenchymal transition in triple-negative breast cancer cells [PDF]

Frontiers in Oncology
The prognosis of triple-negative breast cancer (TNBC) still remains poor, mainly due to the occurrence of early metastases and the lack of effective treatments.
Marzia Deserti, Simone Sabbioni, Francesca Poli, Francesco Vasuri, Francesco Vasuri, Valeria Relli, Andrea Palloni, Chiara Deiana, Giovanni Brandi, Simona Tavolari   +9 more
doaj   +2 more sources