Results 11 to 20 of about 1,582 (158)

RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer [PDF]

Biomolecules, 2019
Raf kinase inhibitor protein (RKIP), an important modulator of intracellular signalling pathways, is commonly downregulated in multiple cancers. This reduction, or loss of expression, is correlated not only with the presence of metastasis, contributing ...
Olga Martinho, Ana Raquel-Cunha, Diana Cardoso-Carneiro   +2 more
exaly   +6 more sources

Regulation of RKIP function by Helicobacter pylori in gastric cancer. [PDF]

PLoS ONE, 2012
Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that infects more than half of the world's population and is a major cause of gastric adenocarcinoma. The mechanisms that link H.
Erika L Moen, Sicheng Wen, Talha Anwar, Sam Cross-Knorr, Kate Brilliant, Faith Birnbaum, Sherida Rahaman, John M Sedivy, Steven F Moss, Devasis Chatterjee   +9 more
doaj   +4 more sources

The YYR (YY1- RKIP) Regulatory Axis in the pathogenesis of Cancer and Immune Evasion [PDF]

Journal of Experimental & Clinical Cancer Research
Background The transcription factor Yin Yang 1 (YY1) and the Raf kinase inhibitory protein (RKIP) represent two molecular entities with diametrically opposed roles in cancer biology.
William Ung, Benjamin Bonavida
doaj   +2 more sources

Prognostic value of RKIP and p-ERK in gastric cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2012
Background The mitogen-activated protein kinase (MAPK) signaling pathway participates in several steps of tumour development and is considered a prominent therapeutic target for the design of chemotherapeutic agents.
Fujimori Yoshitaka, Inokuchi Mikito, Takagi Yoko, Kato Keiji, Kojima Kazuyuki, Sugihara Kenichi   +5 more
doaj   +3 more sources

Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP [PDF]

Scientific Reports
Retinoblastoma is one of the most common ocular malignancies in children. Bmi-1, a member of the Polycomb group family of transcriptional repressors, is expressed in a variety of tumors.
Qian Li, Te Fu, Ning Wei, Qiaoling Wang, Xin Zhang   +4 more
doaj   +2 more sources

Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.

PLoS ONE, 2012
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis.
Olga Martinho, Sara Granja, Teresa Jaraquemada, Cláudia Caeiro, Vera Miranda-Gonçalves, Mrinalini Honavar, Paulo Costa, Margarida Damasceno, Marsha R Rosner, José M Lopes, Rui M Reis   +10 more
doaj   +6 more sources

Cross-Talks between Raf Kinase Inhibitor Protein and Programmed Cell Death Ligand 1 Expressions in Cancer: Role in Immune Evasion and Therapeutic Implications [PDF]

Cells
Innovations in cancer immunotherapy have resulted in the development of several novel immunotherapeutic strategies that can disrupt immunosuppression. One key advancement lies in immune checkpoint inhibitors (ICIs), which have shown significant clinical ...
Mai Ho, Benjamin Bonavida
doaj   +2 more sources

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges. [PDF]

Phytother Res
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Islam MR, Rauf A, Shourav FM, Ogaly HA, Aljohani ASM, Al Abdulmonem W, Badalova K, Iriti M.   +7 more
europepmc   +2 more sources

Expression Analysis of Selected microRNAs in Diabetes Mellitus Visceral Fat Tissues. [PDF]

J Obes
Purpose MicroRNA (miRNA) profiling of visceral adipose tissue in Type‐2 diabetes mellitus (T2DM) remains limited. We compared the expression of obesity‐associated miRNAs in visceral fat from individuals with T2DM versus metabolically healthy obesity (MHO) and examined Raf kinase inhibitory protein (RKIP) as a candidate miR‐543 target.
Al-Temaimi R, Ahmad R, Kapila K, Al-Mulla F.   +3 more
europepmc   +2 more sources

Harnessing RKIP to Combat Heart Disease and Cancer [PDF]

Cancers, 2022
Cancer and heart disease are leading causes of morbidity and mortality worldwide. These diseases have common risk factors, common molecular signaling pathways that are central to their pathogenesis, and even some disease phenotypes that are interdependent.
Kristina Lorenz, Marsha Rich Rosner
openaire   +3 more sources