Investigation of Marine-Derived Natural Products as Raf Kinase Inhibitory Protein (RKIP)-Binding Ligands [PDF]
Marine Drugs, 2021 Raf kinase inhibitory protein (RKIP) is an essential regulator of the Ras/Raf-1/MEK/ERK signaling cascade and functions by directly interacting with the Raf-1 kinase.
Shraddha Parate +3 more
doaj +3 more sources
Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation [PDF]
Frontiers in Molecular Biosciences, 2021 Protein-protein interactions are indispensable physiological processes regulating several biological functions. Despite the availability of structural information on protein-protein complexes, deciphering their complex topology remains an outstanding ...
Shraddha Parate +4 more
doaj +4 more sources
Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. [PDF]
PLoS ONE, 2009 Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon +8 more
doaj +6 more sources
Raf Kinase Inhibitory Protein Regulates the cAMP-Dependent Protein Kinase Signaling Pathway Through a Positive Feedback Loop [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Raf Kinase Inhibitory Protein (RKIP) maintains cellular robustness and prevents the progression of diseases such as cancer and heart disease by regulating key kinase cascades including MAP kinase and protein kinase A (PKA).
Marsha Rosner +2 more
exaly +7 more sources
Protein Kinase A Phosphorylates a Conformationally High-Energy State of Raf Kinase Inhibitory Protein [PDF]
Journal of Molecular BiologyProtein kinase A (PKA) is found in all mammalian tissues and plays a critical role in mediating many signaling processes. The structure and phosphorylation mechanism of the catalytic subunit of PKA (PKA-C) have been extensively studied in interaction ...
Marsha Rosner +2 more
exaly +3 more sources
Regulation on tumor metastasis by Raf kinase inhibitory protein: New insight with reactive oxygen species signaling [PDF]
Tzu Chi Medical Journal, 2021 Targeted therapy aiming at the metastatic signal pathway, such as that triggered by receptor tyrosine kinase (RTK), for the prevention of tumor progression is promising.
Chi-Tan Hu +2 more
doaj +2 more sources
Clinical and Prognostic Significance of Raf Kinase Inhibitory Protein Expression in Gastrointestinal Stromal Tumors [PDF]
World Journal of Gastroenterology, 2018 Wang Y, Chen JJ, Wang XF, Wang Q.
exaly +2 more sources
Biomolecules, 2023 Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases.
Jason A. Kirkbride +7 more
doaj +1 more source
A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. [PDF]
PLoS ONE, 2012 Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy.
Fahd Al-Mulla +4 more
doaj +1 more source
Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents. [PDF]
PLoS ONE, 2011 Influenza A viruses are a severe threat worldwide, causing large epidemics that kill thousands every year. Prevention of influenza infection is complicated by continuous viral antigenic changes.
Mehran Haidari +4 more
doaj +1 more source