Results 21 to 30 of about 4,270,323 (214)

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David, Ostrowski, M C, Hartman, M, Schaffner, A E, Smith, James L., Hume, D A, Smith, J L, Ostrowski, Michael C., Wei, G, Hofmeister, Joseph K., Hofmeister, J K, Schaffner, Alicia E., Wei, Guo, Hume, David A., Hartman, Matthew, Hartman, Matthew Hartman, Forsthoefel, D   +16 more
core   +1 more source

RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. [PDF]

PLoS ONE, 2015
Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus ...
Ila Datar, Jingwei Feng, Xiaoliang Qiu, John Lewandowski, Miranda Yeung, Gang Ren, Shweta Aras, Fahd Al-Mulla, Hongjuan Cui, Robert Trumbly, Sri Krishna Chaitanya Arudra, Luis E De Las Casas, Ivana de la Serna, Milad S Bitar, Kam C Yeung   +14 more
doaj   +1 more source

Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3 [PDF]

, 2011
Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor kappa beta signaling that represses tumor invasion and metastasis.
Tan, Kit Yee, Bitar, Milad S., Al-Ali, W., Abdulla I. Behbehani, Fahd Al-Mulla, Doyle, B., Behbehani, Abdulla I., Al-Ali, Waleed, Al-Mulla, Fahd, May Al-Maghrebi, Oliver Rath, Walter Kolch, Rath, Oliver, Waleed Al-Ali, Al-Maghrebi, May, Al-Mulla, F., Doyle, Brendan, Rath, O., Brendan Doyle, Pitt, A., Tan, K. Y., Behbehani, A. I., Pitt, Andrew; id_orcid, Kolch, Walter, Kolch, W., Al-Maghrebi, M., Kit Yee Tan, Andrew Pitt, Bitar, M. S., Milad S. Bitar   +29 more
core   +1 more source

Mechanism of regulation of Raf-1 by Ca2+/Calmodulin-dependent kinase II [PDF]

, 2011
The calcium-calmodulin dependent kinase II (CaMKII) is an ubiquitous serine/threonine protein kinase involved in multiple signalings and biological functions.
Salzano, Marcella
core   +1 more source

Expression and Significance of Raf Kinase Inhibitory Protein 
in Lung Cancer

Chinese Journal of Lung Cancer, 2012
Background and objective Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein family. RKIP is an endogenous inhibitor of the ERK/MAPK, NF-κΒ, and G protein-coupled receptor signaling pathways.
Dayun YANG, Zhan QI
doaj   +1 more source

Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose

Biomarker Research, 2018
Background For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the ...
Kiera Walker, Nathaniel H. Boyd, Joshua C. Anderson, Christopher D. Willey, Anita B. Hjelmeland   +4 more
doaj   +1 more source

When kinases meet mathematics: the systems biology of MAPK signalling [PDF]

, 2005
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified ...
Calder, M., Kolch, W., Gilbert, D.
core   +1 more source

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion

ASN Neuro, 2015
The epidermal growth factor receptor (EGFR) is linked to the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK 1/2 ) signaling pathways.
Jing Zhou, Ting Du, Baoman Li, Yan Rong, Alexei Verkhratsky, Liang Peng   +5 more
doaj   +1 more source

Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro

Cellular Physiology and Biochemistry, 2016
Background/Aims: Raf kinase inhibitory protein (RKIP) is closely associated with numerous tumors and participates in their development through regulating the growth, apoptosis, invasion and metastasis of tumor cells.
Quanfang Huang, Chunhong Liang, Ling Wei, Jinlan Nie, Shengjuan Lu, Chunyuan Lu, Lang Zhuo, Zhongpeng Lu, Xing Lin   +8 more
doaj   +1 more source

Ligand binding study of human PEBP1/RKIP: interaction with nucleotides and Raf-1 peptides evidenced by NMR and mass spectrometry. [PDF]

PLoS ONE, 2012
BACKGROUND: Human Phosphatidylethanolamine binding protein 1 (hPEBP1) also known as Raf kinase inhibitory protein (RKIP), affects various cellular processes, and is implicated in metastasis formation and Alzheimer's disease.
Laurette Tavel, Lucie Jaquillard, Andreas I Karsisiotis, Fabienne Saab, Laurence Jouvensal, Alain Brans, Agnès F Delmas, Françoise Schoentgen, Martine Cadene, Christian Damblon   +9 more
doaj   +1 more source