Results 11 to 20 of about 4,270,323 (214)

MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation [PDF]

Cell Division, 2007
Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
doaj   +2 more sources

Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. [PDF]

PLoS ONE, 2010
BackgroundRaf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon, Gary L Heil, Alexey E Granovsky, Mathew M Clark, Dan McElheny, Alexander Chimon, Marsha R Rosner, Shohei Koide   +7 more
doaj   +3 more sources

Targeting Raf Kinase Inhibitory Protein Regulation and Function. [PDF]

Cancers (Basel), 2018
Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the ...
Yesilkanal AE, Rosner MR.
europepmc   +2 more sources

Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death

Redox Biology, 2022
Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states.
Andrew M. Lamade, Limin Wu, Haider H. Dar, Heather L. Mentrup, Indira H. Shrivastava, Michael W. Epperly, Claudette M. St Croix, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Qin Yang, Aleksandr A. Kapralov, Zhentai Huang, Gaowei Mao, Andrew A. Amoscato, Zachary E. Hier, Margarita A. Artyukhova, Galina Shurin, Joel C. Rosenbaum, Peter J. Gough, John Bertin, Andrew P. VanDemark, Simon C. Watkins, Kevin P. Mollen, Ivet Bahar, Joel S. Greenberger, Valerian E. Kagan, Michael J. Whalen, Hülya Bayır   +27 more
doaj   +1 more source

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway

Frontiers in Pharmacology, 2021
As a common complication of many cardiovascular diseases, cardiac hypertrophy is characterized by increased cardiac cell volume, reorganization of the cytoskeleton, and the reactivation of fetal genes such as cardiac natriuretic peptide and β-myosin ...
Panpan Chen, Panpan Chen, Zhaoqin Wen, Zhaoqin Wen, Wanlan Shi, Wanlan Shi, Zhongli Li, Xiaoyan Chen, Yang Gao, Shangfu Xu, Qihai Gong, Qihai Gong, Qihai Gong, Jiang Deng, Jiang Deng   +14 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression. [PDF]

PLoS ONE, 2013
The Raf kinase inhibitory protein (RKIP) is down-regulated in multiple types of human cancers. Decreased RKIP transcription activity may be one of the major mechanisms responsible for the downregulation of RKIP expression in human diseases.
Boyan Zhang, Ou Wang, Jingchao Qin, Shuaishuai Liu, Sheng Sun, Huitu Liu, Jian Kuang, Guohua Jiang, Wei Zhang   +8 more
doaj   +1 more source

Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies

Molecules, 2017
RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-based ...
Yu Fu, Yuanyuan Wang, Shanhe Wan, Zhonghuang Li, Guangfa Wang, Jiajie Zhang, Xiaoyun Wu   +6 more
doaj   +1 more source

Limited inhibition of multiple nodes in a driver network blocks metastasis

eLife, 2021
Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling capacity by limited inhibition of core pathways is a more ...
Ali Ekrem Yesilkanal, Dongbo Yang, Andrea Valdespino, Payal Tiwari, Alan U Sabino, Long Chi Nguyen, Jiyoung Lee, Xiao-He Xie, Siqi Sun, Christopher Dann, Lydia Robinson-Mailman, Ethan Steinberg, Timothy Stuhlmiller, Casey Frankenberger, Elizabeth Goldsmith, Gary L Johnson, Alexandre F Ramos, Marsha R Rosner   +17 more
doaj   +1 more source

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development [PDF]

, 2010
Background: Early inner ear development requires the strict regulation of cell proliferation, survival, migration and differentiation, coordinated by the concerted action of extrinsic and intrinsic factors.
Rapp Ulf R., Marta Magariños, Varela-Nieto, Isabel, Hortensia Sánchez-Calderón, Aburto María R., Muñoz-Agudo, Carmen, Muñoz-Agudo Carmen, Rapp, Ulf Rüdiger, Rodriguez Aburto, Maria, María R. Aburto, Magariños Marta, María R Aburto, Sánchez-Calderón, Hortensia, Rapp, Ulf R., Ulf R Rapp, Isabel Varela-Nieto, Varela-Nieto Isabel, Magariños, Marta, Carmen Muñoz-Agudo, Sánchez-Calderón Hortensia, Ulf R. Rapp, Muñoz Agudo, Carmen   +21 more
core   +2 more sources