Results 21 to 30 of about 1,582 (158)
Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. [PDF]
PLoS ONE, 2009 Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon +8 more
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RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. [PDF]
PLoS ONE, 2015 Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus ...
Ila Datar +14 more
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Insights of RKIP-Derived Suppression of Prostate Cancer [PDF]
Cancers, 2021 Prostate cancer (PC) is a major cause of cancer death in men. The disease has a great disparity in prognosis. Although low grade PCs with Gleason scores ≤ 6 are indolent, high-risk PCs are likely to relapse and metastasize. The standard of care for metastatic PC (mPC) remains androgen deprivation therapy (ADT). Resistance commonly occurs in the form of
Ying Dong +6 more
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Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. [PDF]
PLoS ONE, 2010 BackgroundRaf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon +7 more
doaj +1 more source
Exploration of Targeted Anti-tumor Therapy, 2023 The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell
Matthew Moghaddam +4 more
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Marine Drugs, 2021 Raf kinase inhibitory protein (RKIP) is an essential regulator of the Ras/Raf-1/MEK/ERK signaling cascade and functions by directly interacting with the Raf-1 kinase.
Shraddha Parate +3 more
doaj +1 more source
The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart
Cells, 2022 The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen-activated protein kinase) pathway, RKIP acts as a beneficial tumour suppressor.
Joshua Abd Alla, Ursula Quitterer
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Interactions of RKIP with Inflammatory Signaling Pathways [PDF]
Critical Reviews in Oncogenesis, 2014 The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules that may potentiate multiple functions during inflammatory processes.
Jinming, Zhao, Sally, Wenzel
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cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression. [PDF]
PLoS ONE, 2013 The Raf kinase inhibitory protein (RKIP) is down-regulated in multiple types of human cancers. Decreased RKIP transcription activity may be one of the major mechanisms responsible for the downregulation of RKIP expression in human diseases.
Boyan Zhang +8 more
doaj +1 more source
Tzu Chi Medical Journal, 2021 Targeted therapy aiming at the metastatic signal pathway, such as that triggered by receptor tyrosine kinase (RTK), for the prevention of tumor progression is promising.
Chi-Tan Hu +2 more
doaj +1 more source