Results 31 to 40 of about 1,582 (158)

RKIP: A Pivotal Gene Product in the Pathogenesis of Cancer [PDF]

Cancers, 2021
Raf kinase inhibitor protein (RKIP), previously known as a phosphatidylethanolamine-binding protein (PEBP), was cloned by Yeung et al [...]
openaire   +3 more sources

Can acromegaly be controlled in all cases? [PDF]

J Neuroendocrinol
Abstract Acromegaly is a rare disease, due in most of the cases to a growth hormone (GH)‐secreting pituitary adenoma (PA), namely neuroendocrine tumour (PitNET). The treatment of patients with acromegaly is multimodal and multi‐step, including surgery, medical therapies, and radiotherapy.
Chiloiro S, Sorrentino FP, Vicari A, Giampietro A, Mattogno PP, D'Alessandris QG, Calandrelli R, Tartaglione T, Gessi M, Gaudino S, De Marinis L, Rindi G, Doglietto F, Bianchi A, Pontecorvi A.   +14 more
europepmc   +2 more sources

RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. [PDF]

PLoS ONE, 2013
Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several ...
Olga Martinho, Filipe Pinto, Sara Granja, Vera Miranda-Gonçalves, Marise A R Moreira, Luis F J Ribeiro, Celso di Loreto, Marsha R Rosner, Adhemar Longatto-Filho, Rui Manuel Reis   +9 more
doaj   +1 more source

A Role for RKIP in Cell Motility [PDF]

Chemistry & Biology, 2005
The target of locostatin, a small-molecule inhibitor of cell movement, has been identified as RKIP, a Raf-1 kinase modulator [1]. In addition to advancing our understanding of cell locomotion, this work represents a major landmark in the development of chemical genetics.
openaire   +2 more sources

Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival

BMC Cancer, 2011
Background Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of ...
Chia David, Horvath Steve, Vega Mario I, Maresh Erin L, Chatterjee Devasis, Rivera-Pazos Clara M, Mah Vei, Hernandez-Cueto Angeles, Yoon Nam K, Huerta-Yepez Sara, Bonavida Benjamin, Goodglick Lee   +11 more
doaj   +1 more source

Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure

Frontiers in Medicine, 2019
Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e.,
Stefan Wolf, Joshua Abd Alla, Ursula Quitterer, Ursula Quitterer   +3 more
doaj   +1 more source

The biological complexity of RKIP signaling in human cancers [PDF]

Experimental & Molecular Medicine, 2015
The Raf kinase inhibitory protein (RKIP) has been demonstrated to modulate different intracellular signaling pathways in cancers. Studies have shown that RKIP is frequently downregulated in cancers; therefore, attempts have been made to upregulate the expression of RKIP using natural and synthetic agents for the treatment of human malignancies ...
Farooqi, Ammad Ahmad, Li, Yiwei, Sarkar, Fazlul H   +2 more
openaire   +2 more sources

Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-κB Pathway

Cellular Physiology and Biochemistry, 2017
Background: Acute ischemic stroke is one of the most important factors leading to disability and death with the characterization of accumulated neuron death and injured supportive neurovascular structures.
Li Su, Rongrong Zhang, Yuanyuan Chen, Zhenyu Zhu, Chao Ma   +4 more
doaj   +1 more source

A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. [PDF]

PLoS ONE, 2012
Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy.
Fahd Al-Mulla, Milad S Bitar, Jingwei Feng, Sungdae Park, Kam C Yeung   +4 more
doaj   +1 more source

Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer.

PLoS ONE, 2014
Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding-protein (PEBP) family that modulates the action of many kinases involved in cellular growth, apoptosis, epithelial to mesenchymal transition, motility, invasion and ...
Saad Yousuf, MeiLi Duan, Erika L Moen, Sam Cross-Knorr, Kate Brilliant, Benjamin Bonavida, Theresa LaValle, Kam C Yeung, Fahd Al-Mulla, Eugene Chin, Devasis Chatterjee   +10 more
doaj   +1 more source